Younger and Older Adults' Cognitive and Physical Functioning in a Virtual Reality Age Manipulation [0.03%]
虚拟现实年龄操纵下的年轻人和老年人的认知和身体功能状态研究
Nils M Vahle,Martin J Tomasik
Nils M Vahle
Objectives: Age group stereotypes (AGS), especially those targeting old age, affect an individual's behavior and long-term cognitive and physiological functioning. Conventional paradigms investigating the related mechanisms lack validity an...
Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes [0.03%]
帕金森病中检测到的体细胞突变可能会影响参与突触和神经元过程的基因
Irene Lobon,Manuel Solís-Moruno,David Juan et al.
Irene Lobon et al.
The role of somatic mutations in complex diseases, including neurodevelopmental and neurodegenerative disorders, is becoming increasingly clear. However, to date, no study has shown their relation to Parkinson disease's phenotype. To explor...
A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults [0.03%]
一项多中心、随机、双盲、平行对照、安慰剂对照研究，评估 NMN 补充剂 Uthever 在中老年人群中的有效性和安全性
Hao Huang
Hao Huang
Objective: The purpose of the study was to evaluate the anti-aging effect of NMN and its safety in a double-blind, parallel, randomised controlled clinical trial. Methods: The study was carried out on 66 healthy subjects between the ages of...
Association Between Inflammation and Appetite in Healthy Community-Dwelling Older Adults-An enable Study [0.03%]
炎症与健康社区老年人食欲之间的关联-一项ABLE研究
Neshat Chareh,Eva Kiesswetter,Robert Kob et al.
Neshat Chareh et al.
Aging is associated with reduced appetite as well as a slight increase in pro-inflammatory status, which both might contribute to the development of malnutrition. We aimed to evaluate the association between inflammation based on serum C-re...
Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae [0.03%]
二甲双胍通过减轻炎症反应和提高抗体生成量抑制急性肺炎链球菌感染加重
Grace C Lee,Alvaro G Moreira,Cecilia Hinojosa et al.
Grace C Lee et al.
Metformin may potentially reverse various age-related conditions; however, it is unclear whether metformin can also mitigate or delay the deterioration of immunological resilience that occurs in the context of infections that are commonly o...
Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans [0.03%]
利用临床、流行病学和遗传衰老研究中的克隆性血液生成分析来揭示人类年龄相关功能障碍的潜在机制
Kenneth Walsh,Nalini Raghavachari,Candace Kerr et al.
Kenneth Walsh et al.
Aging is characterized by increased mortality, functional decline, and exponential increases in the incidence of diseases such as cancer, stroke, cardiovascular disease, neurological disease, respiratory disease, etc. Though the role of agi...
Modulation of Reactive Oxygen Species Homeostasis as a Pleiotropic Effect of Commonly Used Drugs [0.03%]
常用药物调节反应性氧族平衡的多效性作用
Carolin Thomas,Lia Wurzer,Ernst Malle et al.
Carolin Thomas et al.
Age-associated diseases represent a growing burden for global health systems in our aging society. Consequently, we urgently need innovative strategies to counteract these pathological disturbances. Overwhelming generation of reactive oxyge...
Geranylgeranylacetone Ameliorates Beta-Amyloid Toxicity and Extends Lifespan via the Heat Shock Response in Caenorhabditis elegans [0.03%]
牻牛儿基牻牛儿基乙酸酯通过热休克反应缓解β淀粉样蛋白毒性并延长秀丽隐杆线虫寿命
Isiah Mossiah,Sabrina M Perez,Taylor R Stanley et al.
Isiah Mossiah et al.
Activation of a cytoprotective cellular pathway known as the heat shock response (HSR) is a promising strategy for the treatment of Alzheimer's disease and other neurodegenerative diseases. Geranylgeranylacetone (GGA) is a commonly used ant...
Roadmap for Sex-Responsive Influenza and COVID-19 Vaccine Research in Older Adults [0.03%]
老年人流感和新冠肺炎疫苗性别反应研究路线图
Janna R Shapiro,Rosemary Morgan,Sean X Leng et al.
Janna R Shapiro et al.
Sex differences in the immune system are dynamic throughout the lifespan and contribute to heterogeneity in the risk of infectious diseases and the response to vaccination in older adults. The importance of the intersection between sex and ...
Logan Moore,Zui Pan,Marco Brotto
Logan Moore
Osteoarthritis (OA) is one of the most common causes of disability in aged people, and it is defined as a degenerative arthropathy, characterized by the disruption in joint tissue. The synovium plays a vital role in maintaining the health o...