C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration [0.03%]
秀丽线虫DNA修复、衰老和神经退行性疾病关系研究中的模式动物作用
Francisco José Naranjo-Galindo,Ruixue Ai,Evandro Fei Fang et al.
Francisco José Naranjo-Galindo et al.
Since its introduction as a genetic model organism, Caenorhabditis elegans has yielded insights into the causes of aging. In addition, it has provided a molecular understanding of mechanisms of neurodegeneration, one of the devastating effe...
Dynamic Progress in Technological Advances to Study Lipids in Aging: Challenges and Future Directions [0.03%]
用于研究衰老过程中脂质的动态进展的技术进步：挑战与未来方向
Fangyuan Gao,Emily Tom,Dorota Skowronska-Krawczyk
Fangyuan Gao
Lipids participate in all cellular processes. Diverse methods have been developed to investigate lipid composition and distribution in biological samples to understand the effect of lipids across an organism's lifespan. Here, we summarize t...
The Impact of Aging on the Lung Alveolar Environment, Predetermining Susceptibility to Respiratory Infections [0.03%]
衰老对肺泡微环境的影响及其决定呼吸系统感染易感性的机制研究
Jordi B Torrelles,Blanca I Restrepo,Yidong Bai et al.
Jordi B Torrelles et al.
Respiratory infections are one of the top causes of death in the elderly population, displaying susceptibility factors with increasing age that are potentially amenable to interventions. We posit that with increasing age there are predictab...
Friend or Foe? Defining the Role of Glutamate in Aging and Alzheimer's Disease [0.03%]
是敌还是友？谷氨酸在衰老和阿尔茨海默病中的作用定位
MaKayla F Cox,Erin R Hascup,Andrzej Bartke et al.
MaKayla F Cox et al.
Aging is a naturally occurring decline of physiological processes and biological pathways that affects both the structural and functional integrity of the body and brain. These physiological changes reduce motor skills, executive function, ...
Editorial: The Impact of Immunosenescence and Senescence of Immune Cells on Responses to Infection and Vaccination [0.03%]
述评：免疫衰老及免疫细胞衰老对感染和疫苗接种应答的影响
Anshu Agrawal,Birgit Weinberger
Anshu Agrawal
Tuantuan V Zhao,Yuki Sato,Jorg J Goronzy et al.
Tuantuan V Zhao et al.
The aging process causes profound restructuring of the host immune system, typically associated with declining host protection against cancer and infection. In the case of T cells, aging leads to the accumulation of a diverse set of T-cell ...
William Hongyu Zhang,Seda Koyuncu,David Vilchez
William Hongyu Zhang
Protein homeostasis (proteostasis) is maintained by a tightly regulated and interconnected network of biological pathways, preventing the accumulation and aggregation of damaged or misfolded proteins. Thus, the proteostasis network is essen...
Defining the Roles of Cardiokines in Human Aging and Age-Associated Diseases [0.03%]
心衰肽类在人类衰老及老年疾病中的作用机制研究进展
Himangi Srivastava,Marina Pozzoli,Edward Lau
Himangi Srivastava
In recent years an expanding collection of heart-secreted signaling proteins have been discovered that play cellular communication roles in diverse pathophysiological processes. This minireview briefly discusses current evidence for the rol...
The Replica Set Method is a Robust, Accurate, and High-Throughput Approach for Assessing and Comparing Lifespan in C. elegans Experiments [0.03%]
用于评估和比较秀丽隐杆线虫实验中的寿命的复制集方法是一种稳健、准确且高通量的方法
Adam Cornwell,Jesse R Llop,Peter Salzman et al.
Adam Cornwell et al.
The advent of feeding based RNAi in Caenorhabditis elegans led to an era of gene discovery in aging research. Hundreds of gerogenes were discovered, and many are evolutionarily conserved, raising the exciting possibility that the underlying...
Editorial: Sex Differences in Molecular Mechanisms of Cardiovascular Aging [0.03%]
述评：心血管老化分子机制的性别差异
S Novella,K L Moreau,A P Dantas
S Novella