Sex Differences in Large Artery Stiffness: Implications for Cerebrovascular Dysfunction and Alzheimer's Disease [0.03%]
性别差异与大动脉僵硬度：脑血管功能障碍和阿尔茨海默病的启示
Mackenzie N Kehmeier,Ashley E Walker
Mackenzie N Kehmeier
Two in every three Alzheimer's disease diagnoses are females, calling attention to the need to understand sexual dimorphisms with aging and neurodegenerative disease progression. Dysfunction and damage to the vasculature with aging are stro...
Angiotensin (1-7) Expressing Probiotic as a Potential Treatment for Dementia [0.03%]
血管紧张素(1-7)工程益生菌在痴呆治疗中的潜在应用研究
Abbi R Hernandez,Anisha Banerjee,Christy S Carter et al.
Abbi R Hernandez et al.
Increasing life expectancies are unfortunately accompanied by increased prevalence of Alzheimer's disease (AD). Regrettably, there are no current therapeutic options capable of preventing or treating AD. We review here data indicating that ...
Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse [0.03%]
3xTg-AD小鼠海马-顶叶脑网络中Tau病理学特征与空间重新定位学习和记忆表现有关
Alina C Stimmell,Zishen Xu,Shawn C Moseley et al.
Alina C Stimmell et al.
In early Alzheimer's disease (AD) spatial navigation is one of the first impairments to emerge; however, the precise cause of this impairment is unclear. Previously, we showed that, in a mouse model of tau and amyloid beta (Aβ) aggregation...
Inhibition of miMOMP-induced SASP to combat age-related disease [0.03%]
抑制miR-MOMP诱导的SASP以对抗与年龄相关的疾病
Cellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture. This process is triggered by various stimuli, including oxidative stre...
Immunogenetics of longevity and its association with human endogenous retrovirus K [0.03%]
长寿的免疫遗传学及其与人类内源性逆转录病毒K的关联
Introduction: The human immune system is equipped to neutralize and eliminate viruses and other foreign antigens via binding of human leukocyte antigen (HLA) molecules with foreign antigen epitopes and presenting them to ...