Cara C Hardy
Cara C Hardy
Bothersome urinary symptoms plague many older adults and disproportionally affect women. Underreporting of symptoms and general stigma/embarrassment associated with incontinence has negatively impacted the availability of treatments, as res...
Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill [0.03%]
药物筛选发现硫酸软骨素可能是潜在的长寿药
Collin Y Ewald
Collin Y Ewald
Discovering compounds that promote health during aging ("geroprotectors") is key to the retardation of age-related pathologies and the prevention of chronic age-related diseases. In in-silico and model organisms' lifespan screens, chondroit...
Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8+ EMRA T Cells During Type 2 Diabetes [0.03%]
营养吸收改变导致2型糖尿病期间衰老CD8+EMRAMT细胞线粒体功能障碍
Lauren A Callender,Elizabeth C Carroll,Conor Garrod-Ketchley et al.
Lauren A Callender et al.
Mitochondrial health and cellular metabolism can heavily influence the onset of senescence in T cells. CD8+ EMRA T cells exhibit mitochondrial dysfunction and alterations to oxidative phosphorylation, however, the metabolic properties of se...
The Nitrate-Nitrite-Nitric Oxide Pathway on Healthy Ageing: A Review of Pre-clinical and Clinical Data on the Impact of Dietary Nitrate in the Elderly [0.03%]
硝酸盐-亚硝酸盐-一氧化氮通路与健康衰老：关于膳食硝酸盐影响的临床前和临床证据综述
Bárbara S Rocha
Bárbara S Rocha
We are living longer. Are we living healthier? As we age, cellular and molecular damage reshape our physiological responses towards environmental and endogenous stimuli. The free radical theory of ageing has been proposed long before ageing...
Relationships Between Age, Frailty, Length of Care Home Residence and Biomarkers of Immunity and Inflammation in Older Care Home Residents in the United Kingdom [0.03%]
英国养老院老年人的年龄、脆弱性、居住时间与免疫和炎症生物标志物之间的关系
Vivian M Castro-Herrera,Mark Lown,Helena L Fisk et al.
Vivian M Castro-Herrera et al.
Aging is associated with changes to the immune system, collectively termed immunosenescence and inflammageing. However, the relationships among age, frailty, and immune parameters in older people resident in care homes are not well describe...
The Intestine as a Lifespan- and Proteostasis-Promoting Signaling Tissue [0.03%]
肠道作为促进寿命和蛋白质稳态的信号组织
Francesca Hodge,Viktoria Bajuszova,Patricija van Oosten-Hawle
Francesca Hodge
In multicellular organisms such as Caenorhabditis elegans, cellular stress stimuli and responses are communicated between tissues to promote organismal health- and lifespan. The nervous system is the predominant regulator of cell nonautonom...
Corrina R Elder,Amy E Pasquinelli
Corrina R Elder
The use of Caenorhabditis elegans as a model organism in aging research has been integral to our understanding of genes and pathways involved in this process. Several well-conserved signaling pathways that respond to insulin signaling, diet...
Naibedya Dutta,Gilberto Garcia,Ryo Higuchi-Sanabria
Naibedya Dutta
Organisms are constantly exposed to stress both from the external environment and internally within the cell. To maintain cellular homeostasis under different environmental and physiological conditions, cell have adapted various stress resp...
Aranzazu Arias-Rojas,Igor Iatsenko
Aranzazu Arias-Rojas
Intestinal microbial communities participate in essential aspects of host biology, including nutrient acquisition, development, immunity, and metabolism. During host aging, dramatic shifts occur in the composition, abundance, and function o...
Wei Cao
Wei Cao
Chronic inflammation affects many diseases and conditions, including aging. Interferons are a part of the immune defense against viral infections. Paradoxically, various aging tissues and organs from mammalian hosts perpetually accumulate c...