The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila [0.03%]
GCN2激酶在介导氨基酸对果蝇寿命和摄食行为影响中的作用
Anchal Srivastava,Jiongming Lu,Dennis Said Gadalla et al.
Anchal Srivastava et al.
Restriction of amino acids in the diet can extend lifespan in diverse species ranging from flies to mammals. However, the role of individual amino acids and the underlying molecular mechanisms are only partially understood. The evolutionari...
Tina Kwok,Shannon C Medovich,Ildefonso A Silva-Junior et al.
Tina Kwok et al.
The decreased proportion of antigen-inexperienced, naïve T cells is a hallmark of aging in both humans and mice, and contributes to reduced immune responses, particularly against novel and re-emerging pathogens. Naïve T cells depend on su...
The CBP-1/p300 Lysine Acetyltransferase Regulates the Heat Shock Response in C. elegans [0.03%]
CBP-1/p300乙酰转移酶通过组蛋白和非组蛋白底物介导经典热休克反应在秀丽隐杆线虫中的作用机制研究
Lindsey N Barrett,Sandy D Westerheide
Lindsey N Barrett
The decline of proteostasis is a hallmark of aging that is, in part, affected by the dysregulation of the heat shock response (HSR), a highly conserved cellular response to proteotoxic stress in the cell. The heat shock transcription factor...
Andreas Mylonas,Ana O&#x;Loghlen
Andreas Mylonas
The influence of the activation of a cellular phenotype termed senescence and it's importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic dru...
Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly [0.03%]
老年人的炎症、免疫衰老及失调的免疫调节
Carey Shive,Pushpa Pandiyan
Carey Shive
An optimal immune response requires the appropriate interaction between the innate and the adaptive arms of the immune system as well as a proper balance of activation and regulation. After decades of life, the aging immune system is contin...
Aging Leads to Increased Monocytes and Macrophages With Altered CSF-1 Receptor Expression and Earlier Tumor-Associated Macrophage Expansion in Murine Mesothelioma [0.03%]
衰老导致单核细胞和巨噬细胞增多并改变CSF-1受体表达及小鼠恶性腹膜间皮瘤相关肿瘤巨噬细胞的早期扩增现象
Lelinh Duong,Fiona J Pixley,Delia J Nelson et al.
Lelinh Duong et al.
Increased cancer incidence occurs with the emergence of immunosenescence, highlighting the indispensability of the immune system in preventing cancer and its dysregulation with aging. Tumor-associated macrophages (TAMs) are often present in...
STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases [0.03%]
STIM和Orai介导的钙信号调节在与年龄有关的疾病中的作用
Helen E Collins,Dingguo Zhang,John C Chatham
Helen E Collins
Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse cellular functions including cell survival, metabolism, and transcription. As a result, eukaryotic cells have developed a wide variety of mech...
Combined Vitamin D, Omega-3 Fatty Acids, and a Simple Home Exercise Program May Reduce Cancer Risk Among Active Adults Aged 70 and Older: A Randomized Clinical Trial [0.03%]
维生素D、欧米茄-3脂肪酸和简单的家庭锻炼程序可降低70岁及以上活跃老年人的癌症风险：一项随机临床试验
Heike A Bischoff-Ferrari,Walter C Willett,JoAnn E Manson et al.
Heike A Bischoff-Ferrari et al.
Objective: The aim of this study was to test the individual and combined benefit of vitamin D, omega-3, and a simple home strength exercise program on the risk of any invasive cancer. Design: The DO-HEALTH trial is a three-year, multicenter...
Maximilian Unfried,Li Fang Ng,Amaury Cazenave-Gassiot et al.
Maximilian Unfried et al.
Complexity is a fundamental feature of biological systems. Omics techniques like lipidomics can simultaneously quantify many thousands of molecules, thereby directly capturing the underlying biological complexity. However, this approach tra...
The Usefulness of Radiomics Methodology for Developing Descriptive and Prognostic Image-Based Phenotyping in the Aging Population: Results From a Small Feasibility Study [0.03%]
放射组学方法在基于影像的表型分型方面的应用价值：一项小型可行性研究的结果
Rebeca Mirón Mombiela,Consuelo Borrás
Rebeca Mirón Mombiela
Background: Radiomics is an emerging field that translates medical images into quantitative data to enable phenotypic profiling of human disease. In this retrospective study, we asked whether it is possible to use image-based phenotyping to...