Jianjie Wang,Murtaza M Kazmi,Virginia H Huxley
Jianjie Wang
Objective: The cyclic nucleotide second messengers, cAMP and cGMP, are pivotal regulators of vascular functions; their cellular levels are tightly controlled by the cyclic nucleotide hydrolases, phosphodiesterases (PDE). Biologic sex and ag...
Fiona Ecarnot,Stefania Maggi,Jean-Pierre Michel et al.
Fiona Ecarnot et al.
Background: International tourist travel has been increasingly steadily in recent years, and looks set to reach unprecedented levels in the coming decades. Among these travellers, an increasing proportion is aged over 60 years, and is healt...
Biological Age Prediction From Wearable Device Movement Data Identifies Nutritional and Pharmacological Interventions for Healthy Aging [0.03%]
基于可穿戴设备运动数据的生物年龄预测鉴别出了有益于健康衰老的营养和药物干预措施
Rebecca L McIntyre,Mizanur Rahman,Siva A Vanapalli et al.
Rebecca L McIntyre et al.
Intervening in aging processes is hypothesized to extend healthy years of life and treat age-related disease, thereby providing great benefit to society. However, the ability to measure the biological aging process in individuals, which is ...
Toll-Like Receptors Represent an Important Link for Sex Differences in Cardiovascular Aging and Diseases [0.03%]
toll-like受体代表了心血管老化和疾病性别差异的重要环节
Cinthya Echem,Eliana H Akamine
Cinthya Echem
Human life span expectancy has increased, and aging affects the organism in several ways, leading, for example, to an increased risk of cardiovascular diseases. Age-adjusted prevalence of the cardiovascular diseases is higher in males than ...
The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging [0.03%]
营养感受和mTORC1信号在生理学和衰老研究中的多方面作用
Stephanie A Fernandes,Constantinos Demetriades
Stephanie A Fernandes
The mechanistic Target of Rapamycin (mTOR) is a growth-related kinase that, in the context of the mTOR complex 1 (mTORC1), touches upon most fundamental cellular processes. Consequently, its activity is a critical determinant for cellular a...
Patho-Physiology of Aging and Immune-Senescence: Possible Correlates With Comorbidity and Mortality in Middle-Aged and Old COVID-19 Patients [0.03%]
衰老的病理生理学和免疫老化可能与中老年人新冠肺炎合并症和死亡率的相关性
Saba Farheen,Sudhanshu Agrawal,Swaleha Zubair et al.
Saba Farheen et al.
During the last 2 years, the entire world has been severely devastated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic (COVID-19) as it resulted in several million deaths across the globe. While the virus infect...
Vanessa Dela Justina,Jéssica S G Miguez,Fernanda Priviero et al.
Vanessa Dela Justina et al.
Cardiovascular disease (CVD) is still the leading cause of illness and death in the Western world. Cardiovascular aging is a progressive modification occurring in cardiac and vascular morphology and physiology where increased endothelial dy...
Daniella E Chusyd,Nicole L Ackermans,Steven N Austad et al.
Daniella E Chusyd et al.
Elephants are large-brained, social mammals with a long lifespan. Studies of elephants can provide insight into the aging process, which may be relevant to understanding diseases that affect elderly humans because of their shared characteri...
Direct Imaging of Lipid Metabolic Changes in Drosophila Ovary During Aging Using DO-SRS Microscopy [0.03%]
基于DO-SRS显微镜的果蝇卵巢脂代谢随衰老变化的原位成像研究
Yajuan Li,Pegah Bagheri,Phyllis Chang et al.
Yajuan Li et al.
Emerging studies have shown that lipids and proteins play versatile roles in various aspects of aging. High-resolution in situ optical imaging provides a powerful approach to study the metabolic dynamics of lipids and proteins during aging....
Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification [0.03%]
儿童癌症幸存者和老年人的免疫衰老：比较与风险分层的含义
Petra Lázničková,Kamila Bendíčková,Tomáš Kepák et al.
Petra Lázničková et al.
The population of childhood cancer survivors (CCS) has grown rapidly in recent decades. Although cured of their original malignancy, these individuals are at increased risk of serious late effects, including age-associated complications. An...