Randomized Trial: D-Glyceric Acid Activates Mitochondrial Metabolism in 50-60-Year-Old Healthy Humans [0.03%]
随机试验：D-甘醇酸激活健康人的线粒体代谢
O Petteri Hirvonen,Heikki Kyröläinen,Maarit Lehti et al.
O Petteri Hirvonen et al.
Background: Based on earlier studies, natural metabolite D-glyceric acid (DGA) does not seem to play any role in whole-body metabolism. Nevertheless, one ethanol oxidation-related rat study with controversial results raised our interest. Ac...
Age and CMV-Infection Jointly Affect the EBV-Specific CD8+ T-Cell Repertoire [0.03%]
年龄和CMV感染共同影响EB病毒特异的CD8+t细胞受体 repertoire
Josien Lanfermeijer,Peter C de Greef,Marion Hendriks et al.
Josien Lanfermeijer et al.
CD8+ T cells play an important role in protection against viral infections. With age, changes in the T-cell pool occur, leading to diminished responses against both new and recurring infections in older adults. This is thought to be due to ...
Mayu Inokuchi,Yoko Yamaguchi,Benjamin P Moorman et al.
Mayu Inokuchi et al.
Euryhaline teleost fish are characterized by their ability to tolerate a wide range of environmental salinities by modifying the function of osmoregulatory cells and tissues. In this study, we experimentally addressed the age-related declin...
Di Zhan,Christopher Y Park
Di Zhan
The myelodysplastic syndromes (MDS) represent a group of clonal disorders characterized by ineffective hematopoiesis, resulting in peripheral cytopenias and frequent transformation to acute myeloid leukemia (AML). We and others have demonst...
Adapting Blood DNA Methylation Aging Clocks for Use in Saliva Samples With Cell-type Deconvolution [0.03%]
使用细胞类型去卷积将血液DNA甲基化衰老时钟适应于唾液样本中
Fedor Galkin,Kirill Kochetov,Polina Mamoshina et al.
Fedor Galkin et al.
DeepMAge is a deep-learning DNA methylation aging clock that measures the organismal pace of aging with the information from human epigenetic profiles. In blood samples, DeepMAge can predict chronological age within a 2.8 years error margin...
Gianluca Iacobellis
Gianluca Iacobellis
Epicardial fat is the visceral fat of the heart. Epicardial fat is a white adipose tissue, but it displays also brown-fat like or beige fat features. Under physiological conditions, epicardial fat has cardioprotective functions such as free...
Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy [0.03%]
透射电子显微镜在心脏病线粒体形态和自噬的定性和定量分析中的应用
Helen E Collins,Mariame Selma Kane,Silvio H Litovsky et al.
Helen E Collins et al.
Transmission electron microscopy (TEM) has long been an important technique, capable of high degree resolution and visualization of subcellular structures and organization. Over the last 20 years, TEM has gained popularity in the cardiovasc...
Skeletal Muscle Adaptations to Exercise Training in Young and Aged Horses [0.03%]
青年和老年马运动训练的骨骼肌适应性变化
Christine M Latham,Randi N Owen,Emily C Dickson et al.
Christine M Latham et al.
In aged humans, low-intensity exercise increases mitochondrial density, function and oxidative capacity, decreases the prevalence of hybrid fibers, and increases lean muscle mass, but these adaptations have not been studied in aged horses. ...
INDY-From Flies to Worms, Mice, Rats, Non-Human Primates, and Humans [0.03%]
从果蝇到线虫、小鼠、大鼠、非人灵长类和人类的长寿基因研究进展
Dushyant Mishra,Kavitha Kannan,Kali Meadows et al.
Dushyant Mishra et al.
I'm Not Dead Yet (Indy) is a fly homologue of the mammalian SLC13A5 (mSLC13A5) plasma membrane citrate transporter, a key metabolic regulator and energy sensor involved in health, longevity, and disease. Reduction of Indy gene activity in f...
Neuropathology of Aging in Cats and its Similarities to Human Alzheimer's Disease [0.03%]
猫的神经病理衰老及其与人类阿尔茨海默病的相似性
Lorena Sordo,Alessandra C Martini,E Fiona Houston et al.
Lorena Sordo et al.
Elderly cats develop age-related behavioral and neuropathological changes that ultimately lead to cognitive dysfunction syndrome (CDS). These neuropathologies share similarities to those seen in the brains of humans with Alzheimer's disease...