CD123-Directed Bispecific Antibodies for Targeting MDS Clones and Immunosuppressive Myeloid-Derived Suppressor Cells (MDSC) in High-Risk Adult MDS Patients [0.03%]
针对高风险成人MDS患者的CD123导向双特异性抗体以靶向MDS克隆和免疫抑制性髓源性抑制细胞(MDSC)
Fatih M Uckun,Justin Watts
Fatih M Uckun
There is an urgent need to identify effective strategies to prevent leukemic transformation and induce sustained deep remissions in adult high-risk myelodysplastic syndrome (MDS) patients. This article discusses the clinical impact potentia...
Evidence that C/EBP-β LAP Increases Fat Metabolism and Protects Against Diet-Induced Obesity in Response to mTOR Inhibition [0.03%]
C/EBP-β LAP增加脂肪代谢并可通过抑制mTOR来抵抗饮食诱导的肥胖：相关证据
Alessandro Bitto,Nicole Tatom,Thomas Krivak et al.
Alessandro Bitto et al.
Aging and obesity are common risk factors for numerous chronic pathologies, and the compounding effects of old age and increased adiposity pose a serious threat to public health. Starting from the assumption that aging and obesity may have ...
Inflammasome Activity in Response to Influenza Vaccination Is Maintained in Monocyte-Derived Peripheral Blood Macrophages in Older Adults [0.03%]
流感疫苗接种后老年人外周血单核细胞源性巨噬细胞中炎性小体活性的维持
Stephen N Crooke,Krista M Goergen,Inna G Ovsyannikova et al.
Stephen N Crooke et al.
Introduction: Each year, a disproportionate number of the total seasonal influenza-related hospitalizations (90%) and deaths (70%) occur among adults who are >65 years old. Inflammasome activation has been shown to be important for protecti...
Jun Jin,Huimin Zhang,Cornelia M Weyand et al.
Jun Jin et al.
Lysosomes were initially recognized as degradation centers that regulate digestion and recycling of cellular waste. More recent studies document that the lysosome is an important signaling hub that regulates cell metabolism. Our knowledge o...
Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases [0.03%]
小鼠大脑皮层O-GlcNAc修饰蛋白数量和位点的动态调控及神经退行性疾病相关突触和转运膜蛋白的O-GlcNAc位点鉴定
Van N Huynh,Sheng Wang,Xiaosen Ouyang et al.
Van N Huynh et al.
O-linked conjugation of ß-N-acetyl-glucosamine (O-GlcNAc) to serine and threonine residues is a post-translational modification process that senses nutrient availability and cellular stress and regulates diverse biological processes that a...
Implications of Inflammatory States on Dysfunctional Immune Responses in Aging and Obesity [0.03%]
炎症状态对衰老和肥胖引起的免疫功能障碍的影响
Alyssa L Thomas,Pablo C Alarcon,Senad Divanovic et al.
Alyssa L Thomas et al.
Aging and obesity are two conditions characterized by chronic, low-grade inflammation. While both conditions are also associated with dysfunctional immune responses, the shared and distinct underlying mechanisms are just starting to be unco...
Obesity Accelerates Age-Associated Defects in Human B Cells Through a Metabolic Reprogramming Induced by the Fatty Acid Palmitate [0.03%]
棕榈酸诱导的代谢重编程加速肥胖状态下人类B细胞衰老相关缺陷
Daniela Frasca,Maria Romero,Denisse Garcia et al.
Daniela Frasca et al.
We have measured the secretion of autoimmune antibodies in plasma samples and in culture supernatants of blood-derived B cells from four groups of individuals: young lean (YL), elderly lean (EL), young obese (YO) and elderly obese (EO). We ...
Simple Detection Methods for Senescent Cells: Opportunities and Challenges [0.03%]
衰老细胞的简易检测方法：机遇与挑战
Richard G A Faragher
Richard G A Faragher
Cellular senescence, the irreversible growth arrest of cells from conditional renewal populations combined with a radical shift in their phenotype, is a hallmark of ageing in some mammalian species. In the light of this, interest in the det...
G-quadruplexes Stabilization Upregulates CCN1 and Accelerates Aging in Cultured Cerebral Endothelial Cells [0.03%]
G-四聚体稳定通过上调CCN1促进培养脑内皮细胞衰老
Brian Noh,Maria P Blasco-Conesa,Yun-Ju Lai et al.
Brian Noh et al.
Senescence in the cerebral endothelium has been proposed as a mechanism that can drive dysfunction of the cerebral vasculature, which precedes vascular dementia. Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) is a matricellular protein se...
Freek Manders,Ruben van Boxtel,Sjors Middelkamp
Freek Manders
From conception to death, human cells accumulate somatic mutations in their genomes. These mutations can contribute to the development of cancer and non-malignant diseases and have also been associated with aging. Rapid technological develo...