Effects of physical disability and widowhood on the survival of centenarians: a 7-year follow-up of CHCCS centenarians [0.03%]
身体残疾和丧偶对百岁老人生存的影响：CHCCS百岁老人队列的7年随访研究
Songmei Han,Dongxu Zhao,Jianbo Wu et al.
Songmei Han et al.
Background: Centenarians, being at the end of their life span, are particularly vulnerable to various health risks. Multiple factors can influence their survival and targeted intervention on these factors may promote heal...
Preventing ovarian aging: from redox-targeted strategies to extracellular vesicle-based therapies [0.03%]
防治卵巢早衰：从抗氧化策略到细胞外囊泡疗法
Chiara Camerano Spelta Rapini,Camila Cecilia Rojo-Fleming,Chiara Di Berardino et al.
Chiara Camerano Spelta Rapini et al.
Ovarian aging is increasingly recognized as a dynamic and modifiable process influenced by oxidative stress, mitochondrial dysfunction, and chronic inflammation. This review outlines the mechanisms by which environmental and lifestyle facto...
Marco Antonio Mejía-Barrera,Enya Enara Martínez-Torres,Ulises Juárez-Figueroa et al.
Marco Antonio Mejía-Barrera et al.
Fanconi anemia (FA) is a rare genetic disorder characterized by genomic instability, bone marrow failure, physical abnormalities, and increased cancer susceptibility. Growing evidence suggests that. FA may represent a progeroid syndrome, di...
Reduction of calreticulin and ERp57 with age reveals the ER stress-related roles in cell viability and organismal lifespan regulation [0.03%]
钙连蛋白和ERp57的衰老性降低揭示了内质网压力相关作用在细胞存活和生物体寿命调节中的作用
Gregor Burdeos,Sophie Neuber-Schlicht
Gregor Burdeos
Introduction: Defects in Calreticulin (Calr) and ER protein 57 (ERp57), two tandem endoplasmic reticulum (ER) resident proteins, are associated with pathologies ranging from protein conformational disorders to impaired im...
One-month early time-restricted eating mitigates brain aging and enhances memory in males with metabolic syndrome: an MRI structural study [0.03%]
一项针对代谢综合征男性的MRI结构研究表明，提前一个月的限时进食可缓解大脑衰老并增强记忆力
Yue Qin,Xiaoshi Li,Lei Wang et al.
Yue Qin et al.
Background: Metabolic syndrome (MetS) has emerged as a global health concern challenges to human brain aging and memory function. While early time-restricted eating (eTRE) has been widely recognized as an effective dietar...
Obesity and low lean mass are associated with dysregulated IGFBP-3, inflammatory biomarkers, and physical impairment in older adult women with frailty [0.03%]
肥胖和低肌肉量与老年人脆弱女性IGFBP-3失调、炎症生物标志物和身体功能障碍有关
Alan L Fernandes,Rosa M R Pereira,Valeria F Caparbo et al.
Alan L Fernandes et al.
Introduction: Prior studies indicate sex-specific obesity-frailty interactions, with postmenopausal estrogen decline increasing sarcopenic obesity risk and inflammation in women. This study evaluated circulating cytokines...
Cardiovascular risk factor changes associated with six-year circuit training in older adults: a retrospective cohort analysis [0.03%]
老年人六年循环训练相关的心血管风险因素变化：回顾性队列分析
Marcelo Pereira de Lima,Renata Miyabara,Lujain Fouad Khalaf et al.
Marcelo Pereira de Lima et al.
Background: Physical exercise can significantly impact chronic disease prevention and health promotion in older adults. This retrospective cohort study evaluated the association between participation in a multidisciplinar...
Impact of comorbidities in patients with erosive hand osteoarthritis (EHOA), a monocentric study [0.03%]
合并症对侵蚀性手骨关节炎患者的影响：单中心研究
S Bindoli,G Cozzi,C Benvoluti et al.
S Bindoli et al.
Objective: Erosive hand osteoarthritis (EHOA) is a severe and rapidly progressing form of osteoarthritis that has been linked to systemic comorbidities (i.e., metabolic bone and cardiovascular diseases). The object of thi...
Does time spent upright moderate the influence of a weighted vest on change in bone mineral density during weight loss among older adults? A secondary analysis of the INVEST in bone health randomized controlled trial [0.03%]
穿戴加重背心对老年人体重减轻期间骨密度变化的影响的二次分析研究：站立时间是否起到了调节作用？
Jason Fanning,Daniel P Beavers,Shirley M Bluethmann et al.
Jason Fanning et al.
Introduction: The INVEST in Bone Health randomized controlled trial examined whether 1 year of weight loss paired with resistance training (WL+RT) or weighted vest use (WL+VEST) sustained bone mineral density (BMD) at the...
Age-related hearing loss in healthy older adults is associated with arterial stiffening and higher aortic systolic blood pressure: potential role of inflammation [0.03%]
健康老年人的年龄相关性听力下降与动脉硬化及主动脉收缩压升高有关：炎症的潜在作用
Nicholas A Carlini,Lynn M Bielski,Courtney N Mudd et al.
Nicholas A Carlini et al.
Age-related aortic stiffening increases aortic (central) blood pressure and flow pulsatility, resulting in microvascular dysfunction and target organ damage. The relationship between aortic stiffness, aortic blood pressure, and age-related ...