Emerging PFAS contaminants PFNA and PFSA amplify epigenetic aging: sex- and age-stratified risks in an aging population [0.03%]
新兴的PFAS污染物PFNA和PFSA会加剧表观遗传老化：老龄化人群中的性别和地区分层风险评估
Ya-Qian Xu,Chongyu Ding,Hui Zhang et al.
Ya-Qian Xu et al.
Emerging perfluoroalkyl substances (PFAS), such as perfluorononanoic acid (PFNA) and perfluorosulfonic acid (PFSA), are pervasive environmental contaminants that may influence human health. Their effects on aging, particularly through recen...
Evaluating the performance of large language models in sarcopenia-related patient queries: a foundational assessment for patient-centered validation [0.03%]
评估大型语言模型在与 sarcopenia 相关的患者查询中的表现：以患者为中心的验证的基础评估
Tao Huang,Ben Kirk,Jacqueline Close et al.
Tao Huang et al.
Background: Large Language Models (LLMs) have shown promise in clinical applications but their performance in specialized areas such as sarcopenia remains understudied. ...
Development and validation of a machine learning-based risk prediction model for sarcopenia in community hospital patients: a retrospective cohort study [0.03%]
基于机器学习的社区医院患者肌少症风险预测模型的开发与验证：回顾性队列研究
Xue Zhao,Wang Yao,Jiawei Shen et al.
Xue Zhao et al.
Introduction: Sarcopenia, a progressive age-related loss of skeletal muscle mass and strength, represents a growing public health challenge amid global population aging. Early detection remains difficult with conventional...
Non-pharmacological mental health interventions for older adults in Mexico: a systematic review [0.03%]
墨西哥老年人非药物心理健康干预的系统评价
María Fernanda Zapata-De la Rosa,Harvey Apolonio-Cortés,Rodrigo Ramirez-Rodriguez et al.
María Fernanda Zapata-De la Rosa et al.
Introduction: The accelerated aging of the Mexican population presents an urgent public health challenge, particularly regarding geriatric mental health. While non-pharmacological interventions (NPIs) offer a promising th...
Ectoine attenuates H2O2-Induced cellular senescence in human keratinocytes and endothelial cells by modulating the p53/p21 and p16 pathways [0.03%]
依羧肽氨酸通过调节p53 / p21和p16途径减弱人角质形成细胞和内皮细胞中的H2O2诱导的细胞衰老
Meini Li,Jingyue Zhang,Wenke Yang et al.
Meini Li et al.
Background: Ectoine ((S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) is a major compatible solute found in halophilic microorganisms from salt lakes. The anti-cellular senescence effect and skin safety of Ect...
Editorial: Insights in genetics, genomics and epigenomics of aging: 2025 [0.03%]
述评：遗传、基因和表观基因组学衰老研究洞见：2025年展望
Marcella Reale
Marcella Reale
Editorial: Unraveling the complexities of premature aging: mechanisms and interventions [0.03%]
述评：早衰症的机制及干预措施不容小觑
Mayank Choubey,Shivani Srivastava,Vinay Kumar
Mayank Choubey
Effect of milk and dairy intake on cognitive function in older adults: a systematic review and meta-analysis [0.03%]
乳制品摄入与老年人认知功能的关系：一项系统综述和荟萃分析
Yessica Giraldo-Castrillon,Juan Diego Mendoza,Marianne Lopez-Cabrera et al.
Yessica Giraldo-Castrillon et al.
Introduction: Cognitive aging represents a growing challenge for global public health. Nutrition could have a beneficial effect in preserving cognitive function, and dairy products have been proposed as neuroprotective du...
Elevated circulating GDF11 and its role in age-related sarcopenia: insights from clinical, transcriptomic, and in vitro analyses [0.03%]
循环GDF11水平升高及其在年龄相关性肌肉减少症中的作用：来自临床、转录组学和体外分析的见解
Rui Chen,Xin Dai,Hong Wang et al.
Rui Chen et al.
Introduction: Growth differentiation factor 11 (GDF11), a member of the transforming growth factor-β (TGF-β) superfamily, has been implicated in aging and muscle homeostasis. However, its clinical relevance and mechanis...
Use of sensing technologies to assess sleep quality and physical activity levels in nursing home residents with dementia taking nightly psychotropic drugs for sleep disturbance: a cross-sectional study [0.03%]
用于评估养老院居民夜间服用镇静药物的痴呆症患者的睡眠质量和身体活动水平的技术检测方法：横断面研究
Lydia D Boyle,Brice Marty,Kristoffer Haugarvoll et al.
Lydia D Boyle et al.
Background: Sleep disturbances are common in people with dementia and nightly prescribed psychotropic drugs, such as sedatives or antidepressants, can increase risks such as injury, inactivity, and behavioral symptoms. Tr...