Building a framework for integrative longevity science: from rediscovery to innovation [0.03%]
构建整合长寿科学框架：从再发现到创新
Marta Gonzalez-Freire
Marta Gonzalez-Freire
The longevity research field is experiencing unprecedented momentum, driven by advances in molecular biomarkers, digital health technologies, and artificial intelligence. However, established physiological measures-VO2max, heart rate variab...
Senescence-associated secretory phenotype: the "pathogenic" factor driving orthopedic degenerative diseases and its regulation [0.03%]
衰老相关分泌表型在骨科退行性疾病中的促病机制及其调控
Junxiao Ren,Xiangjin Wang,Xin Zhou et al.
Junxiao Ren et al.
Orthopedic degenerative diseases, including osteoarthritis (OA), intervertebral disc degeneration (IVDD), and osteoporosis (OP), are major causes of chronic pain and functional decline in aging populations worldwide. The senescence-associat...
Velocity-based resistance training in institutionalized older adults: protocol for an experimental study with follow-up [0.03%]
基于速度的阻力训练在机构养老老年人中的应用：一项实验研究方案及随访
Ángel Buendía-Romero,Héctor Gutiérrez-Reguero,Lucia Romero-Valia et al.
Ángel Buendía-Romero et al.
Background: The effects of velocity-based resistance training (VBRT) in institutionalized older adults remain poorly explored. This protocol aims to describe a study designed to i) analyze the effects of a 9-month VBRT pr...
Dietary pyrroloquinoline quinone and spermidine in healthy longevity: targeting the hallmarks of aging [0.03%]
膳食吡咯喹啉醌和腐胺与健康长寿：针对衰老的标志性特征
Tomoe Numaguchi,Mai Nakamura,Tomoyo Koshizawa et al.
Tomoe Numaguchi et al.
Background: Aging is a multifaceted biological process driven by interconnected cellular and molecular hallmarks. As geroscience increasingly prioritizes healthspan over lifespan, nutritional interventions targeting multi...
Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial [0.03%]
烟酰胺核糖和pterostilbene可降低围绝经期不适症状的频率和严重程度：一项开放标签、初步临床试验
Holly E Holmes,Kamal Srivastava,Jennifer M Scalici et al.
Holly E Holmes et al.
Introduction: Nicotinamide adenine dinucleotide (NAD+) is a metabolite of vitamin B3 necessary for the production of key hormones like estradiol. Both NAD+ and estradiol levels decrease with age. Reduced estradiol levels ...
Clinical Trial
Frontiers in aging. 2026 May 13:7:1773667. DOI:10.3389/fragi.2026.1773667 2026
Experiences and challenges of in-hospital rehabilitation exercise among older adults with hip fracture arthroplasty in a fast-track program: a qualitative study [0.03%]
快速康复途径下髋部骨折置换术老年患者的住院锻炼体验与挑战——定性研究
Jianlin Ji,Endong Xie,Yan Li et al.
Jianlin Ji et al.
Introduction: Hip fractures are a major global health problem for older adults and fast-track programs are now widely used to improve outcomes. However, older adults following hip fracture arthroplasty often faced difficu...
Social wellbeing in older breast cancer survivors taking adjuvant endocrine therapy: impacts of self-efficacy for symptom management and pain [0.03%]
乳腺癌术后接受辅助内分泌治疗的老年幸存者的社会福祉：症状管理和疼痛自我效能感的影响
Nicole A Arrato,Addison D Monroe,Francis J Keefe et al.
Nicole A Arrato et al.
Introduction: For older breast cancer survivors taking adjuvant endocrine therapy (AET), side effects are common and significantly impact quality of life. Self-efficacy is an important protective factor in this population...
Rare and novel genetic variants in sporadic and familial Alzheimer's disease: insights from the first Saudi cohort [0.03%]
散发性和家族性阿尔茨海默病中的罕见和新型基因变异：来自沙特阿拉伯首个队列的启示
Fadia El Bitar,Ghadeer Al Dawsari,Najeeb Qadi et al.
Fadia El Bitar et al.
Background: Alzheimer's disease (AD) is a complex brain disorder that is greatly affected by genetics. Next-generation sequencing (NGS) has facilitated the discovery of rare variants in new genes that may be linked to AD ...
Jhommara Bautista,Andrés López-Cortés
Jhommara Bautista
Aging is increasingly recognized as a biologically heterogeneous process arising from dynamic interactions among genetic programs, environmental exposures, and adaptive physiological responses. Within the geroscience framework, conserved ha...
Modifiable lifestyle factors and 4.9-Year changes in phenotypic age in the Taiwan biobank [0.03%]
台湾生物样本库中可改变的生活方式因素对表型年龄4.9年的变化的影响
Wan-Yu Lin
Wan-Yu Lin
Introduction: Phenotypic age (PhenoAge) is a composite biomarker that reflects biological aging by integrating indicators of immune, metabolic, liver, and kidney function. ...