Mateus Vidigal de Castro,João Paulo Limongi França Guilherme,Mayana Zatz
Mateus Vidigal de Castro
Turner Syndrome (TS), caused by complete or partial monosomy of chromosome X, is associated with increased morbidity and reduced life expectancy, largely driven by cardiovascular, endocrine, and metabolic complications. Here, we report the ...
Efficacy of simultaneous aerobic and cognitive training (Activ4Brain) on physical fitness and body composition in older persons [0.03%]
有氧与认知同时训练（Activ4Brain）对老年人身体健康和体成分的影响效力研究
Kaan Akalp,Hicran Besikci,Afonso Rainho Mateus et al.
Kaan Akalp et al.
Introduction: The popularity of simultaneously integrated cognitive training and exercise programs is increasingly adopted as a strategy to mitigate age-related declines in cognitive function and physical fitness, and the...
Coronary angiography-derived microcirculatory resistance predicts adverse cardiovascular events in elderly with unstable angina post-percutaneous coronary intervention [0.03%]
基于冠状动脉造影的微循环阻力可预测不稳定性心绞痛经皮冠状动脉介入术后老年人不良心血管事件发生
Kangming Li,Lele Wang,Panqing Liao et al.
Kangming Li et al.
Background: Coronary microvascular dysfunction (CMD) has been increasingly recognized as a critical determinant of adverse cardiovascular outcomes. The coronary angiography-derived index of microcirculatory resistance (ca...
Gender- and domain-specific effects of a 6-month multidimensional exercise program on attention and verbal fluency in physically inactive older adults [0.03%]
针对身体不活跃老年人的认知功能，一项为期六个月的多维度锻炼计划具有性别和认知领域特异性的效果：一项随机对照试验
Marlene Krumpolt,Anneke Schumacher,Lucas Sannemann et al.
Marlene Krumpolt et al.
Background: Regular physical activity supports cognitive functioning in older age, yet little is known about domain- and gender-specific adaptations following multidimensional training. This study examined the effects of ...
The metabolic-epigenetic landscape of aging: interplay between histone acetylation, lactylation, and glycation [0.03%]
衰老的代谢-表观遗传景观：组蛋白乙酰化、乳酰化和糖基化的相互作用
Olena Bolgova,Inna Shypilova,Volodymyr Mavrych
Olena Bolgova
Background: The aging epigenome is shaped by three mechanistically distinct histone post-translational modifications-acetylation, lactylation, and glycation-each driven by a different metabolic flux: mitochondrial oxidati...
The SIRT1-p53 axis drives a ferro-aging-like program and aggravates trophoblast dysfunction in preeclampsia [0.03%]
SIRT1-p53信号轴通过启动类似铁死亡的衰老程序加剧子痫前期滋养细胞功能障碍
Rong Hu,Zhi Chen,Wei Bian et al.
Rong Hu et al.
Preeclampsia (PE) is a pregnancy-specific syndrome driven by placental dysfunction, and premature placental senescence has increasingly been implicated in its pathogenesis. However, the upstream regulatory mechanisms remain poorly understoo...
Homeodynamic Rejuvenation: an adaptive framework for resetting skin aging [0.03%]
动态机体复苏：适应性框架在重置皮肤老化方面的应用
Anthony Brown,Carla Simonetto,Carlos López-Otín
Anthony Brown
Skin aging reflects not only the accumulation of molecular damage, but also a progressive decline in the skin's ability to restore equilibrium under continuous environmental stress. Classical models distinguishing intrinsic and extrinsic ag...
Studying exercise-induced affect in older adults: how the circumplex model could enhance theoretical and practical advances in the field [0.03%]
老年群体运动诱导的情绪研究：如何利用情绪维度模型推动该领域理论与实践的发展
Attila Szabo,Celal Bulgay,Erzsébet Stephens-Sarlós et al.
Attila Szabo et al.
Although decades of research show the health benefits of regular exercise in older adults, the affective mechanisms underlying these benefits remain poorly understood. In fact, research on exercise-induced affect has generally lacked a clea...
Increased neurotoxic gliosis and blood-brain barrier dysregulation in canine cognitive dysfunction syndrome (CCD) [0.03%]
犬认知功能障碍综合征中的神经毒性星形胶质细胞增生和血脑屏障失调现象加重
Sean W Boland,Greta N Coyner,Sydney J Risen et al.
Sean W Boland et al.
Background: As Alzheimer's Disease (AD) and related dementias (ADRD) prevalence is projected to double by 2050, the urgency for relevant models to study its pathology intensifies. Aging is the primary risk factor for AD d...
Deep cervical lymphaticovenous anastomosis for Alzheimer's disease: theoretical foundations, regulatory suspension, and translational challenges [0.03%]
用于阿尔茨海默病的深部颈椎淋巴静脉吻合术：理论基础、监管暂停和转化挑战
Gang Li,Shusheng Jiao,Yi Zhou et al.
Gang Li et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by pathological changes in β-amyloid protein deposition, abnormal tau protein phosphorylation neurofibrillary tangles, and chronic neuroinflammation. Recent studies hav...