High-Avidity Anti-Filovirus IgG Elicited Using Protein Subunit Vaccines Does Not Correlate with Protection [0.03%]
高水平抗(filovirus)IgG抗体的蛋白疫苗与保护作用无相关性
Caitlin A Williams,Teri Ann S Wong,Michael M Lieberman et al.
Caitlin A Williams et al.
Zaire ebolavirus (EBOV) poses a significant threat to public health due to its high case fatality rate and epidemic potential. This is further complicated by the lack of precise immune correlates of protection and difficulties in conducting...
Exploring the Interplay between Fatty Acids, Inflammation, and Type 2 Diabetes [0.03%]
探究脂肪酸、炎症和2型糖尿病之间的相互作用
Dequina A Nicholas,Jacques C Mbongue,Darysbel Garcia-Pérez et al.
Dequina A Nicholas et al.
Around 285 million people worldwide currently have type 2 diabetes and it is projected that this number will be surpassed by 2030. Therefore, it is of the utmost importance to enhance our comprehension of the disease's development. The regu...
A Serological Multiplexed Immunoassay (MIA) Detects Antibody Reactivity to SARS-CoV-2 and Other Viral Pathogens in Liberia and Is Configurable as a Multiplexed Inhibition Test (MINT) [0.03%]
一种血清学多重免疫检测法(MIA)可检测利比里亚和其他病毒病原体的SARS-CoV-2抗体反应，并可配置为多重抑制试验(MINT)
Brien K Haun,Albert To,Caitlin A Williams et al.
Brien K Haun et al.
The SARS-CoV-2 pandemic ignited global efforts to rapidly develop testing, therapeutics, and vaccines. However, the rewards of these efforts were slow to reach many low- to middle-income countries (LMIC) across the African continent and glo...
Brian Jeong,Kalipada Pahan
Brian Jeong
Macrophages are myeloid phagocytic leukocytes whose functions are to protect against infections, mediate T-cell responses, and maintain tissue homeostasis. IL-12p40 monomer is a cytokine that is largely produced by macrophages, and it has, ...
Laurent Calvier,Anna E Alexander,Joachim Herz
Laurent Calvier
Under pathological conditions like multiple sclerosis (MS), leukocytes infiltrate the central nervous system where they, in concert with activated microglia, promote inflammatory demyelination resulting in a broad spectrum of symptoms inclu...
Autophagy in Virus Infection: A Race between Host Immune Response and Viral Antagonism [0.03%]
自噬在病毒感染中：宿主免疫反应与病毒拮抗间的竞争
Karan Chawla,Gayatri Subramanian,Tia Rahman et al.
Karan Chawla et al.
Virus-infected cells trigger a robust innate immune response and facilitate virus replication. Here, we review the role of autophagy in virus infection, focusing on both pro-viral and anti-viral host responses using a select group of viruse...