Are CD4+ T-Cell Counts Associated with Pneumocystis jirovecii Detection in Hospitalized Patients with Liver Disease? A Retrospective Exploratory Pilot Analysis [0.03%]
CD4⁺ T细胞计数与肝病住院患者Pneumocystis jirovecii检测相关性分析：一项回顾性探索性分析研究
Antonios Katsounas,Amer Nashtar,Jasmin Weninger et al.
Antonios Katsounas et al.
Background: Advanced cirrhosis induces profound CD4+ T-cell depletion through splenic sequestration and immune dysregulation. Pneumocystis jirovecii pneumonia risk thresholds remain undefined in non-HIV immunocompromised ...
Hartmut Jaeschke,Mitchell R McGill
Hartmut Jaeschke
Effects of Chronic Elevation in Plasma Membrane Cholesterol on the Function of Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1) [0.03%]
慢性升高胆汁酸受体膜胆固醇对Na+/牛磺胆酸共转运多肽（NTCP）和有机阳离子转运蛋白1（OCT1）功能的影响
Jessica Y Idowu,Caylie McKimens,Bruno Hagenbuch
Jessica Y Idowu
Background: We have previously demonstrated that the function and expression of the Na+/taurocholate cotransporting polypeptide (NTCP) and the organic cation transporter 1 (OCT1) are affected by increasing free or unester...
Serological Status of Vaccine and Hepatitis B Virus Exposure Among Children Under 5 and Aged 15-17 Years in Kampala, Uganda [0.03%]
乌干达坎帕拉地区5岁以下和15至17岁年龄组儿童疫苗接种及乙型肝炎病毒感染血清学状况调查
Fahad Muwanda,Edward Kiyonga,Joan Nambafu et al.
Fahad Muwanda et al.
Background: Pediatric hepatitis B virus (HBV) serostatus remains variably characterized, hardly determined at times, or documented as part of national monitoring of the Extended Programs for Immunization (EPI). ...
Multifaceted Human Antigen R (HuR): A Key Player in Liver Metabolism and MASLD [0.03%]
多面体的人类抗原受体R（HuR）：肝代谢和MASLD的关键参与者
Natalie Eppler,Elizabeth Jones,Forkan Ahamed et al.
Natalie Eppler et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the leading cause of chronic liver disease worldwide, affecting approximately 25-30% of the global adult population and highlighting the urgent need for effective t...
Jeffrey Wu,Bradley Maller,Rujul Kaul et al.
Jeffrey Wu et al.
The use of high-dose acetaminophen (AAP) with n-acetylcysteine (NAC) rescue was studied as an anti-cancer treatment in phase I trials with promising signals of anti-tumor efficacy. Correlative analysis suggested that AAP has a free-radical-...
Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity [0.03%]
铁 mitochondria 吸收在乙酰氨基酚引起的肝毒性中的作用
Jiangting Hu,Anna-Liisa Nieminen,Zhi Zhong et al.
Jiangting Hu et al.
Overdose of acetaminophen (APAP) produces fulminant hepatic necrosis. The underlying mechanism of APAP hepatotoxicity involves mitochondrial dysfunction, including mitochondrial oxidant stress and the onset of mitochondrial permeability tra...
Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics [0.03%]
理解代谢功能障碍相关脂肪肝病中巨噬细胞的复杂性：从M1/M2范式向空间动力学转变
Forkan Ahamed,Natalie Eppler,Elizabeth Jones et al.
Forkan Ahamed et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses metabolic dysfunction-associated fatty liver (MASL) and metabolic dysfunction-associated steatohepatitis (MASH), with MASH posing a risk of progression to cirrhosi...
Targeting Autophagy for Acetaminophen-Induced Liver Injury: An Update [0.03%]
靶向自噬以对抗乙酰氨基酚致肝损伤：最新研究进展
Kaitlyn Hinz,Mengwei Niu,Hong-Min Ni et al.
Kaitlyn Hinz et al.
Acetaminophen (APAP) overdose can induce hepatocyte necrosis and acute liver failure in experimental rodents and humans. APAP is mainly metabolized via hepatic cytochrome P450 enzymes to generate the highly reactive metabolite N-acetyl-p-be...
Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose [0.03%]
腺苷A2B受体向线粒体的转位影响乙酰氨基酚过量后的细胞色素P450 2E1活性
Giselle Sanchez-Guerrero,David S Umbaugh,Abhay A Ramachandran et al.
Giselle Sanchez-Guerrero et al.
The adenosine A2B receptor (A2BAR) is a member of a family of G-protein coupled receptors (GPCRs), which has a low affinity for adenosine and is now implicated in several pathophysiological conditions. We have demonstrated the beneficial ef...