CRISPR-mediated promoter editing of a cis-regulatory element of OsNAS2 increases Zn uptake/translocation and plant yield in rice [0.03%]
利用CRISPR介导的OsNAS2顺式调控元件的启动子编辑提高水稻中的Zn吸收/转运及植物产量
Yvonne Ludwig,Conrado Dueñas Jr,Erwin Arcillas et al.
Yvonne Ludwig et al.
Developing nutritious rice with a higher yield is one approach to alleviating the problem of micronutrient deficiency in developing countries, especially human malnutrition involving zinc and iron (Fe) deficiency, and achieving better adopt...
CRISPR/Cas9: an advanced platform for root and tuber crops improvement [0.03%]
CRISPR / Cas9：用于根和块茎作物改良的高级平台
K Divya,Makeshkumar Thangaraj,N Krishna Radhika
K Divya
Root and tuber crops (RTCs), which include cassava, potato, sweet potato, and yams, principally function as staple crops for a considerable fraction of the world population, in addition to their diverse applications in nutrition, industry, ...
Delger Bayarsaikhan,Edina Poletto
Delger Bayarsaikhan
Computational analysis of cas proteins unlocks new potential in HIV-1 targeted gene therapy [0.03%]
Cas蛋白的计算分析为HIV-1靶向基因治疗解锁了新的潜力
Will Dampier,Rachel Berman,Michael R Nonnemacher et al.
Will Dampier et al.
Introduction: The human immunodeficiency virus type 1 (HIV-1) pandemic has been slowed with the advent of anti-retroviral therapy (ART). However, ART is not a cure and as such has pushed the disease into a chronic infection. One potential c...
What do people think about genetic engineering? A systematic review of questionnaire surveys before and after the introduction of CRISPR [0.03%]
人们对基因工程的看法是什么？CRISPR引入前后问卷调查的系统性回顾
Pedro Dias Ramos,Maria Strecht Almeida,Ingrid Anna Sofia Olsson
Pedro Dias Ramos
The advent of CRISPR-Cas9 in 2012 started revolutionizing the field of genetics by broadening the access to a method for precise modification of the human genome. It also brought renewed attention to the ethical issues of genetic modificati...
Diversity of transgene integration and gene-editing events in wheat (Triticum aestivum L.) transgenic plants generated using Agrobacterium-mediated transformation [0.03%]
农杆菌介导转化产生的小麦(Triticum aestivum L.)转基因植株中外源基因整合及基因编辑事件的多样性
Louie Cris Lopos,Natalia V Bykova,Janeen Robinson et al.
Louie Cris Lopos et al.
Improvement in agronomic traits in crops through gene editing (GE) relies on efficient transformation protocols for delivering the CRISPR/Cas9-coded transgenes. Recently, a few embryogenesis-related genes have been described, the co-deliver...
Progress in gene editing tools, implications and success in plants: a review [0.03%]
基因编辑工具的进展，对植物的影响和成功案例：综述
Suman Jyoti Bhuyan,Manoj Kumar,Pandurang Ramrao Devde et al.
Suman Jyoti Bhuyan et al.
Genetic modifications are made through diverse mutagenesis techniques for crop improvement programs. Among these mutagenesis tools, the traditional methods involve chemical and radiation-induced mutagenesis, resulting in off-target and unin...
Enabling genome editing in tropical maize lines through an improved, morphogenic regulator-assisted transformation protocol [0.03%]
通过改进的morphogenic调节辅助转化方案在热带玉米材料中实现基因组编辑
José Hernandes-Lopes,Maísa Siqueira Pinto,Letícia Rios Vieira et al.
José Hernandes-Lopes et al.
The recalcitrance exhibited by many maize (Zea mays) genotypes to traditional genetic transformation protocols poses a significant challenge to the large-scale application of genome editing (GE) in this major crop species. Although a few ma...
Germline ablation achieved via CRISPR/Cas9 targeting of NANOS3 in bovine zygotes [0.03%]
CRISPR/Cas9靶向NANOS3实现牛受精卵的生殖细胞消减
Maci L Mueller,Bret R McNabb,Joseph R Owen et al.
Maci L Mueller et al.
NANOS3 is expressed in migrating primordial germ cells (PGCs) to protect them from apoptosis, and it is known to be a critical factor for germline development of both sexes in several organisms. However, to date, live NANOS3 knockout (KO) c...
Reciprocal mutations of lung-tropic AAV capsids lead to improved transduction properties [0.03%]
相互作用的肺趋向性AAV衣壳突变体可改善腺相关病毒基因治疗载体的转导能力
Ashley L Cooney,Christian M Brommel,Soumba Traore et al.
Ashley L Cooney et al.
Considerable effort has been devoted to developing adeno-associated virus (AAV)-based vectors for gene therapy in cystic fibrosis (CF). As a result of directed evolution and capsid shuffling technology, AAV capsids are available with widesp...