Pigs lacking TMPRSS2 displayed fewer lung lesions and reduced inflammatory response when infected with influenza A virus [0.03%]
缺乏TMPRSS2的猪在感染流感病毒后肺部病灶减少炎症反应降低
Giovana Ciacci Zanella,Celeste A Snyder,Bailey L Arruda et al.
Giovana Ciacci Zanella et al.
Influenza A virus (IAV) infection is initiated by hemagglutinin (HA), a glycoprotein exposed on the virion's lipid envelope that undergoes cleavage by host cell proteases to ensure membrane fusion, entry into the host cells, and completion ...
CRISPR-Cas9 immune-evasive hESCs are rejected following transplantation into immunocompetent mice [0.03%]
移植到免疫健全小鼠体内后，CRISPR-Cas9免疫逃避型人胚胎干细胞被排斥
Henriette Reventlow Frederiksen,Alexandra Glantz,Kåre Kryger Vøls et al.
Henriette Reventlow Frederiksen et al.
Although current stem cell therapies exhibit promising potential, the extended process of employing autologous cells and the necessity for donor-host matching to avert the rejection of transplanted cells significantly limit the widespread a...
Editorial: Applications of novel gene editing tools and approaches in plants [0.03%]
植物新型基因组编辑工具与策略的应用展望
Cheng Yuan,Tong Zhang,Changjun Huang
Cheng Yuan
Fan Luo,Qiankun Wang,Shuliang Chen
Fan Luo
Finja Bohle,Robin Schneider,Juliane Mundorf et al.
Finja Bohle et al.
Recently, the European Commission (EC) published a regulatory proposal on plants generated with new genomic techniques (NGTs) (5 July 2023). According to this proposal, NGT plant applications are categorized into category 1 NGT (NGT1) and c...
Pigs lacking the SRCR5 domain of CD163 protein demonstrate heritable resistance to the PRRS virus and no changes in animal performance from birth to maturity [0.03%]
SRCR5结构域缺失的CD163蛋白型猪对PRRSV具有遗传抗性且不影响生长育种值评分
Clint Nesbitt,Lucina Galina Pantoja,Benjamin Beaton et al.
Clint Nesbitt et al.
Porcine reproductive and respiratory syndrome (PRRS) is one of the world's most persistent viral pig diseases, with a significant economic impact on the pig industry. PRRS affects pigs of all ages, causing late-term abortions and stillbirth...
Jonas De Saeger,Emma Coulembier Vandelannoote,Hojun Lee et al.
Jonas De Saeger et al.
This minireview examines the current state and challenges of genome editing in macroalgae. Despite the ecological and economic significance of this group of organisms, genome editing has seen limited applications. While CRISPR functionality...
Jennifer J Waldo,Julian A N M Halmai,Kyle D Fink
Jennifer J Waldo
Epigenetics refers to the molecules and mechanisms that modify gene expression states without changing the nucleotide context. These modifications are what encode the cell state during differentiation or epigenetic memory in mitosis. Epigen...
Nuclease-free precise genome editing corrects MECP2 mutations associated with Rett syndrome [0.03%]
无核酸精准基因编辑纠正与瑞特综合征相关MECP2突变
Swati Bijlani,Ka Ming Pang,Lakshmi V Bugga et al.
Swati Bijlani et al.
Rett syndrome is an acquired progressive neurodevelopmental disorder caused by de novo mutations in the X-linked MECP2 gene which encodes a pleiotropic protein that functions as a global transcriptional regulator and a chromatin modifier. R...
Revolutionizing in vivo therapy with CRISPR/Cas genome editing: breakthroughs, opportunities and challenges [0.03%]
利用CRISPR/Cas基因编辑革新区内治疗：突破、机遇和挑战
Arturo Macarrón Palacios,Patrick Korus,Bodo G C Wilkens et al.
Arturo Macarrón Palacios et al.
Genome editing using the CRISPR/Cas system has revolutionized the field of genetic engineering, offering unprecedented opportunities for therapeutic applications in vivo. Despite the numerous ongoing clinical trials focusing on ex vivo geno...