Normal Iron Homeostasis Requires the Transporter SLC48A1 for Efficient Heme-Iron Recycling in Mammals [0.03%]
正常铁稳态需要SLC48A1转运器在哺乳动物中高效地回收血红素铁
William R Simmons,Lily Wain,Joseph Toker et al.
William R Simmons et al.
In mammals over 65% of the total body iron is located within erythrocytes in the heme moieties of hemoglobin. Iron homeostasis requires iron absorbed from the diet by the gut as well as recycling of iron after the destruction of senescent e...
Jasmine L Carter,Julian A N M Halmai,Kyle D Fink
Jasmine L Carter
Understanding of cell-type specific transcription factors has promoted progress in methods for cellular reprogramming, such as directly reprogramming somatic cells to induced neurons (iN). Methods for direct reprogramming require neuronal-f...
CRISPR/Cas9 Mutagenesis by Translocation of Cas9 Protein Into Plant Cells via the Agrobacterium Type IV Secretion System [0.03%]
通过农杆菌IV型分泌系统将Cas9蛋白转运至植物细胞从而实现基因突变
Daan J Schmitz,Zahir Ali,Chenglong Wang et al.
Daan J Schmitz et al.
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is a powerful tool for genome engineering in plants. The RNA-guided Cas9 endonuclease is usually delivered into plant cells as a DNA const...
Genome Editing Technologies for Rice Improvement: Progress, Prospects, and Safety Concerns [0.03%]
用于水稻改良的基因编辑技术：进展、前景和安全问题
Kashaf Zafar,Khalid E M Sedeek,Gundra Sivakrishna Rao et al.
Kashaf Zafar et al.
Rice (Oryza sativa) is an important staple food crop worldwide; to meet the growing nutritional requirements of the increasing population in the face of climate change, qualitative and quantitative traits of rice need to be improved. Stress...
Gene Editing and Alzheimer's Disease: Is There Light at the End of the Tunnel? [0.03%]
基因编辑与阿尔茨海默病：隧道尽头有光吗？
Mikhail Stepanichev
Mikhail Stepanichev
Alzheimer's disease continues to be a fatal, incurable neurodegenerative disease, despite many years of efforts to find approaches to its treatment. Here we review recent studies on Alzheimer's disease as a target for gene therapy and speci...
Acquiring Resistance Against a Retroviral Infection via CRISPR/Cas9 Targeted Genome Editing in a Commercial Chicken Line [0.03%]
通过CRISPR/Cas9基因编辑技术使肉鸡品系获得抗逆转录病毒感染的能力
Romina Hellmich,Hicham Sid,Kamila Lengyel et al.
Romina Hellmich et al.
Genome editing technology provides new possibilities for animal breeding and aid in understanding host-pathogen interactions. In poultry, retroviruses display one of the most difficult pathogens to control by conventional strategies such as...
Bing Yang
Bing Yang
Chen Liang
Chen Liang
Grand Challenges in Gene and Epigenetic Editing for Neurologic Disease [0.03%]
基因和表观遗传编辑在神经系统疾病治疗中的重大挑战
David J Segal
David J Segal
Fast-TrACC: A Rapid Method for Delivering and Testing Gene Editing Reagents in Somatic Plant Cells [0.03%]
快速的植物体细胞基因编辑递送和测试方法Fast-TrACC
Ryan A Nasti,Matthew H Zinselmeier,Macy Vollbrecht et al.
Ryan A Nasti et al.
The production of transgenic or gene edited plants requires considerable time and effort. It is of value to know at the onset of a project whether the transgenes or gene editing reagents are functioning as predicted. To test molecular reage...