A short-term sublethal oral exposure to microcystin-LR disrupts cecal microbiome homeostasis in mallard [0.03%]
短期口服微囊藻毒素-LR暴露破坏绿翅鸭盲肠微生物群稳态
Serguei V Drovetski,Valerie I Shearn-Bochsler,Erik K Hofmeister et al.
Serguei V Drovetski et al.
Introduction: The frequency of cyanobacterial blooms seems to have increased globally in recent decades due to human induced eutrophication and climate change. Cyanobacterial blooms can produce several groups of toxins, a...
Intravenously administered iron oxide nanoparticles with different coatings reversibly perturb immune cells in peripheral blood without inducing toxicity in mice [0.03%]
不同涂层的静脉注射铁氧化纳米颗粒可逆地改变小鼠外周血免疫细胞而不诱导毒性反应
Preethi Korangath,Chun-Ting Yang,Sean Healy et al.
Preethi Korangath et al.
Introduction: Iron oxide nanoparticle formulations are widely used in clinical applications and have recently been explored for hyperthermia therapy, cancer imaging and treatment. Here, we report the effects of intravenou...
Refining the safety assessment of newly expressed proteins in GMOs [0.03%]
转基因安全评估中关于新表达蛋白的评价方法需进一步完善
Elena Sánchez-Brunete,Arianna Ferrari,F Javier Moreno et al.
Elena Sánchez-Brunete et al.
The European Food Safety Authority (EFSA) carries out safety assessments of newly expressed proteins (NEPs) in genetically modified organisms (GMOs). Here, toxicity and allergenicity assessments are the cornerstone of NEP evaluation, ensuri...
Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM's regulatory scientific confidence framework [0.03%]
人相关效价阈值在推论性能筛选中的复制：用于ICCVAM监管科学信心框架的雌激素受体α激动剂测试案例
Jessica Ryman,Richard A Becker
Jessica Ryman
Scientific confidence frameworks (SCFs) are alternatives to traditional validation for new approach methodologies (NAMs). The SCFs adapted by the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) and the ...
Advancing human health risk assessment: the role of new approach methodologies [0.03%]
推动人类健康风险评估的发展——新方法学的作用
Deepika Deepika,Kanchan Bharti,Shubh Sharma et al.
Deepika Deepika et al.
New Approach Methodologies (NAMs) hold great potential to fill data gaps for chemicals and modernisation of chemical risk assessment practices. Current toxicity testing is based on conventional approaches with high reliability on in-vivo st...
Pesticides, an urgent challenge to global environmental health and planetary boundaries [0.03%]
农药是全球环境健康和地球边界的一个紧迫挑战
Laura N Vandenberg,Elise J Pierce,Rachel M Arsenault
Laura N Vandenberg
There is increasing evidence that pesticides act as endocrine disruptors, developmental toxicants, and reproductive toxicants. In this review, we describe several global challenges associated with pesticide production and use that put the h...
Characterizing chlorotriazine effects in cancer-relevant high-throughput screening assays [0.03%]
氯三氮苯对癌症相关高通量筛选模型的影响研究
Agnes L Karmaus,Alex Charlton
Agnes L Karmaus
Introduction: High-throughput screening (HTS) in vitro testing can be a powerful tool for evaluating chemicals across an abundance of mechanistic, targeted assay systems. This study reviewed HTS in vitro data for the syst...
Promoting ethical and reproducible cell culture: implementing animal-free alternatives to teaching in molecular and cell biology [0.03%]
促进伦理及可重复的细胞培养：在分子和细胞生物学教学中实施无动物替代品
Alexandra Nessar,Viola Röhrs,Mathias Ziersch et al.
Alexandra Nessar et al.
The widespread use of fetal bovine serum (FBS) and other animal-derived reagents in cell culture raises ethical concerns and scientific limitations, including batch variability and undefined composition. To address these challenges and prom...
Proliferation and metabolic activity of the Atlantic sturgeon cell line AOXlar7y under short-term serum-reduced conditions, and the effect of stimulation with growth factors and cytokines [0.03%]
无血清条件下短周期内美洲扬子鱼细胞株AOXlar7y的增殖和代谢活性及其与生长因子和细胞因子刺激的关系
Valeria Di Leonardo,Julia Brenmoehl,Heike Wanka et al.
Valeria Di Leonardo et al.
Introduction: Fish cell lines represent a powerful tool for studying the biology and toxicology of aquatic species in compliance with the 3Rs principles. In addition, they hold potential for more advanced biotechnological...
Hospital admissions for acute drug poisoning in adults and children: a 7-year retrospective analysis of hospital discharges at a tertiary center [0.03%]
成人及儿童急性药物中毒住院病例的7年回顾分析
Daniel Wang,Lina Camacho-Arteaga,Rosario Muñoz Gallarín et al.
Daniel Wang et al.
Background: Drug poisoning is a growing public health concern, affecting both adult and pediatric populations. The COVID-19 pandemic has further influenced the incidence and patterns of these episodes. This study describe...