Establishing scientific confidence: human biological relevance of reconstructed human respiratory epithelium (RHRE) for assessing respiratory effects [0.03%]
建立科学信心：评估呼吸作用的重建人类呼吸道上皮细胞（RHRE）的人体生物学相关性
Nuria Roldan,Emily N Reinke,Helena T Hogberg et al.
Nuria Roldan et al.
In vitro test methods can be used to evaluate the effects of inhaled substances on the human respiratory tract. Scientists are increasingly using these tools due to interest in maximizing reliability and human-relevance, and therefore, the ...
NAMs for closing knowledge gaps in assessment of respiratory uptake - a PARC project [0.03%]
用于评估呼吸道摄取知识差距的NAMs——PARC项目的一部分
Pierre-André Billat,Tanja Hansen,Véronique De Bruijn et al.
Pierre-André Billat et al.
Inhalation is a major route of chemical exposure for both consumers and workers. Physiologically-based kinetic (PBK) modeling is a promising tool to understand the absorption, distribution, metabolism, and excretion (ADME) of inhaled chemic...
A NAMs-based framework for screening the endocrine-disrupting potential of plastic additives using cross-species molecular docking and Caenorhabditis elegans [0.03%]
基于NAM的跨物种分子对接和线虫筛选塑料添加剂内分泌干扰潜能的框架
Chaein Chong,Donghyeon Kim,Keon Kang et al.
Chaein Chong et al.
The increasing global production of plastics has raised concerns about additive chemicals that can leach from polymer matrices and lead to widespread human and environmental exposure. While regulatory attention to endocrine-disrupting chemi...
Pregnancy and lactation exposure to bisphenol S induces ferroptosis via disrupted hepatic lipid metabolism in offspring mice [0.03%]
妊娠期和哺乳期接触双酚S通过扰乱子代小鼠肝脏脂质代谢诱导铁死亡
Mengfen Pan,Xinxin Guo,Caiyun Wei et al.
Mengfen Pan et al.
Introduction: Bisphenol S (BPS), a widely used environmental endocrine disruptor, induces multigenerational liver injury, though its underlying mechanisms remain unclear. ...
Case Report: Ultra-early tangential excision combined with negative pressure wound therapy as a novel surgical detoxification strategy for severe hydrofluoric acid burns complicated by intractable hypocalcemia [0.03%]
病例报告：用于严重氟氢酸烧伤并发顽固性低钙血症的外科解毒新策略——超早期切取植皮术联合负压封闭引流技术
Xiaokun Tian,Bin Xu,Kai Zhang et al.
Xiaokun Tian et al.
Introduction: Severe hydrofluoric acid (HF) burns are life-threatening due to the rapid systemic absorption of fluoride ions, which precipitate profound hypocalcemia and fatal arrhythmias. Traditional conservative neutral...
Biochemical and genomic characterization of last-resort antibiotic resistance and oxidant tolerance in environmental E. coli [0.03%]
环境中的大肠杆菌中最后治疗手段的抗生素抗药性及强氧化剂耐受性的生化和基因组特征分析
Asmaa Al-Mesaifri,Reem Ali,Abdallah Alhaj Sulaiman et al.
Asmaa Al-Mesaifri et al.
Colistin is currently reserved as a last-resort antibiotic for multidrug-resistant Gram-negative bacteria such as pan-resistant Escherichia coli. Colistin-resistant E. coli strains have been detected in wastewater, clinical, and agricultura...
Impact of liquid dosing and associated cell 'drowning' in a 3D human bronchial epithelial model used for protease exposure studies [0.03%]
三维人支气管上皮模型用于蛋白酶暴露研究中液体制剂的影响及相关细胞“溺水”现象
Georgina Hopkins,David Sheffield,Hugh Barlow et al.
Georgina Hopkins et al.
Introduction: As part of a programme of work developing human-relevant New Approach Methodologies (NAMs) for next-generation risk assessment (NGRA), use of a human air-liquid interface (ALI) bronchial epithelial model (Mu...
Hyperbaric oxygen therapy for ischemic encephalopathy following occupational exposure to high-concentration toxic gases: two Case Reports [0.03%]
高压氧治疗职业性高浓度有毒气体暴露后脑梗死2例报告
Yang Pang,Jiaojiao Yuan,Xu Yuan et al.
Yang Pang et al.
Hyperbaric oxygen therapy (HBOT) is effective in managing ischemic encephalopathy of various etiologies, particularly following acute intoxication with specific gases. Considering the limited clinical evidence regarding HBOT for hypoxic enc...
Advancing chemical mixture toxicity assessment using advanced in vitro NAMs: current status and future perspectives [0.03%]
利用体外高通量筛选和替代方法推进混合物毒理学研究：现状与未来展望
Hyunwoo Kim,Donghyeon Kim,Jinhee Choi
Hyunwoo Kim
Chemical exposure in real-world settings occurs predominantly as mixtures, whereas toxicological assessment has long been shaped by single-substance paradigms. As interest in more human-relevant and mechanistically informative testing strat...
Micro- and nanoplastic exposure as an emerging risk factor for depressive-like phenotypes across species: a systematic review [0.03%]
微塑料和纳米塑料暴露作为一种跨物种的抑郁样表型新兴风险因素：系统性综述
Donato Morena,Damiano Marchesini,Monica La Greca et al.
Donato Morena et al.
The pervasive environmental presence of micro- and nanoplastics (MNPs), combined with their ability to cross biological barriers and accumulate in the brain, has raised significant concerns regarding their neurotoxic potential. While neuroi...