Risk assessment of metals measured in regulated Canadian dried cannabis and cannabis vaping products: case study and perspectives [0.03%]
基于加拿大管制干大麻和大麻蒸气产品的金属检测结果开展风险评估：案例研究与展望
Sathish Achuthan,Andrew Waye,Hanan Abramovici
Sathish Achuthan
In 2018, the Cannabis Act and its regulations established a strict legal framework for controlling production, distribution, sale and possession of cannabis across Canada. At that time, smoking dried cannabis was the most prevalent mode of ...
A user-informed perspective of the toxicological data gap in India's cannabis landscape [0.03%]
印度大麻领域的毒理学数据缺口的用户视角
Muzafar Riyaz
Muzafar Riyaz
Clinical research on cannabinoids relies on purified compounds and controlled dosing, creating a data gap that ignores the realities of illicit markets. This perspective, informed by thirteen years of firsthand experience within India's pro...
Testicular mitochondrial redox imbalance and impaired oxidative phosphorylation underlie microplastic-induced testicular dysfunction in Wistar rats [0.03%]
微塑料通过引起大鼠睾丸线粒体氧化还原失衡和呼吸链功能障碍诱导睾丸损伤
Samuel Abiodun Kehinde,Tolulope Peter Fatokun,Sarva Mangala Praveena et al.
Samuel Abiodun Kehinde et al.
Polyethylene microplastics (PE-MPs), now pervasive environmental contaminants, have been implicated in reproductive toxicity, but their mechanistic effects on testicular function remain poorly defined. This study investigates the mechanisti...
The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats [0.03%]
Tirzepatide对缓解大鼠顺铂诱发的神经毒性和认知障碍无效
Hanan Mubarak Almutairi,Ahmad Hamad Alhowail
Hanan Mubarak Almutairi
Introduction: Cisplatin (CIS) is a commonly utilized chemotherapeutic agent, but its use is often accompanied by adverse effects such as neurotoxicity and cognitive impairments, collectively referred to as chemobrain. Thi...
The zebrafish in toxicology: a bibliometric analysis reveals current trends and future avenues for predictive safety assessment [0.03%]
毒理学中的斑马鱼：基于文献计量分析揭示预测安全性评估的当前趋势及未来方向
Carla Lima,Darlan Gusso,Geonildo Rodrigo Disner et al.
Carla Lima et al.
The zebrafish (Danio rerio) has become an indispensable model in toxicological research, bridging environmental monitoring, disease modeling, and preclinical drug screening. This study presents a comprehensive bibliometric and methodologica...
Food contaminants: mechanisms of toxicity, computational assessment, and mitigation [0.03%]
食品安全：毒理机制、计算评估及缓解方法
Laura Escorihuela,Rajesh Kumar Pathak,Benjamí Martorell et al.
Laura Escorihuela et al.
Understanding the toxicological mechanisms of food contaminants is critical for assessing risks to human health. This review comprehensively examines their adverse effects, tracing the pathway from molecular initiation to systemic organ-lev...
Bridging science and curriculum: preparing future leaders in computational toxicology [0.03%]
计算毒理学未来领军人才的培养：从科学到课程的设计与实施
Frances Hall,Candice Johnson
Frances Hall
Computational toxicology plays an important role in chemical safety assessments. Computational methods are applied to early-stage screening in drug discovery, hazard identification, and regulatory safety assessment. This article presents an...
Role of bisphenol A in the aberrant activation of ionotropic glutamate transporters in the cerebral cortex and altered behavioral responses in C57BL/6J mice [0.03%]
双酚A对C57BL/6J小鼠大脑皮质离子型谷氨酸受体激活及行为反应的影响研究
Jasim Khan,Mohammad Waseem,Kajal Kamble et al.
Jasim Khan et al.
Bisphenol A (BPA) is a widely used endocrine-disrupting chemical that is used to manufacture epoxy resins and polycarbonate plastics. Dietary intake is considered the primary source of human exposure through leaching into food and beverages...
Combined lipid emulsion and plasma exchange in massive pediatric bupropion overdose: Case Report [0.03%]
丙咪嗪儿童中毒联合应用脂质注射液和血浆置换治疗：案例报告
Brett Russell,Michael Reedy,Kristina M Flathers et al.
Brett Russell et al.
Introduction: Massive bupropion overdose in pediatric patients can result in refractory cardiogenic shock, seizures, and cardiac arrest requiring aggressive intervention. Although lipid emulsion (LE), therapeutic plasma e...
Beyond the amyloid hypothesis: leveraging human-centered complex in vitro models to decode Alzheimer's disease etiology [0.03%]
超越淀粉样蛋白假说：利用人类导向的复杂体外模型解码阿尔茨海默病病因学
Matthew Price,Francesca Pistollato
Matthew Price
Alzheimer's disease (AD) is a complex neurodegenerative condition and the leading cause of dementia worldwide. Treatments that safely and effectively counteract disease progression are currently lacking. While the formation of amyloid plaqu...