Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds [0.03%]
基于多公司验证的啮齿动物饲养箱监测技术在临床前药物安全评估中的应用：三个化合物非临床和临床数据的结果
R R Sillito,J Sutherland,A Milne et al.
R R Sillito et al.
Introduction: The presence of central nervous system (CNS) safety concerns during early clinical testing that were not picked up in standard preclinical assessment is a major cause of attrition in drug development. It is ...
Comprehensive methodology for standardized ecotoxicological assessment of TiO2-based sunscreen leachates in aquatic environment [0.03%]
基于TiO2的防晒霜浸出液的生态毒理学标准化评估的全面方法学研究
Roberta Nugnes,Giulia De Negri Atanasio,Elisabetta Perata et al.
Roberta Nugnes et al.
Introduction: This study evaluates the ecotoxicity of micro- and nano-sized titanium dioxide (TiO2), either as active ingredients or incorporated into sunscreen formulations in the aquatic environment, by proposing a leac...
Montmorillonite-based essential oil carrier and its effects on non-target species: an environmental perspective on its risk assessment [0.03%]
关于montmorillonite基精油载体及其对非靶标生物的影响：环境风险评估视角
Sofia Machado,Catarina Ganilho,Tatiana Andreani et al.
Sofia Machado et al.
Introduction: Essential oils (EO), rich in bioactive metabolites with biocidal activity, present great potential for agricultural applications as new biopesticides. However, their high volatility and sensitivity to enviro...
Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions [0.03%]
无动物衍生的细胞外基质水凝胶替代品？在无动物培养条件下具有静态和动态培养条件的HepaRG细胞的探索性研究
Katharina S Nitsche,Paul L Carmichael,Sophie Malcomber et al.
Katharina S Nitsche et al.
New approach methodologies (NAMs) aim for animal-free chemical risk assessments. However, many in vitro NAM models still depend heavily on Matrigel and collagen despite the ethical, reproducibility, and biomedical concerns regarding the use...
Developing an approach for evaluating the cardiotoxic potential of botanicals [0.03%]
开发一种评估草药心脏毒性的方法
Julie Krzykwa,Hemantkumar S Chaudhari,Andre Monteiro Da Rocha et al.
Julie Krzykwa et al.
Botanicals (e.g., extracts derived from plants, algae, or fungi) are increasingly utilized by consumers with the hope of enhancing their health, managing symptoms, or preventing ailments; however, these products have often had limited pre-m...
A toxicological assessment of Hericium erinaceus (Lion's mane) and Trametes versicolor (Turkey tail) mushroom powders [0.03%]
亚狮茸和云芝子实体的毒理学评估
Kritika Mahadevan,Julie Daoust,Thomas Brendler et al.
Kritika Mahadevan et al.
Hericium erinaceus (Lion's mane) and Trametes versicolor (Turkey Tail) mushrooms have an extensive history of use in traditional medicine and as food. Oftentimes, they are available as extract preparations produced from selected life stages...
Toxicological and nutritional evaluation of plant cell cultures from scurvy grass (Cochlearia danica) and rowan (Sorbus aucuparia) [0.03%]
来自坏血病草(Cochlearia danica)和山杨(Sorbus aucuparia)植物细胞培养物的毒性及营养评价
Felicianna,Ho Lam Cheung,Emily Kwun Kwan Lo et al.
Felicianna et al.
Introduction: Plant cell culture (PCC) technology is currently being developed to produce plant foods partially decoupled from traditional agriculture practices. By now, the safety of the ingredients produced by PCC techn...
Toxicological effects of sublethal microcystin-LR exposure in Labeo rohita: histopathological, ultrastructural, immunological, and biochemical impairments [0.03%]
微囊藻毒素-LR亚致死暴露对罗非鱼毒性效应的研究：组织病理学、免疫学和生化损伤的影响
Snatashree Mohanty,Anirban Paul,K V Rajendran et al.
Snatashree Mohanty et al.
Introduction: Microcystins (MCs) are alarming aquatic contaminants having extensive health implications in fish. Despite growing concern, comprehensive studies on long term effects of MCs remain unexplored in Labeo rohita...
Danger on the plate: human health risks derived from the consumption of angular angelshark (Squatina guggenheim) meat in southeastern Brazil [0.03%]
盘中危险：东南巴西消费濒危睡鲨（Squatina guggenheim）肉对人类健康的威胁
Amanda Pontes Lopes,Rebeca Dias de Souza Coutinho,Tatiana Dillenburg Saint&#x;Pierre et al.
Amanda Pontes Lopes et al.
Introduction: Shark and ray species are particularly vulnerable to pollutant bioaccumulation, including metals and metalloids, due to their k-strategist characteristics and mid-high trophic level. The angular angelshark (...
Phenotypically anchored transcriptomics across diverse agrichemicals reveals conserved pathways and unique gene expression signatures in zebrafish [0.03%]
基于表型的转录组学研究揭示了斑马鱼在各种农业化学品中的保守途径和独特的基因表达模式
Lindsey St Mary,Ryan McClure,Lisa Truong et al.
Lindsey St Mary et al.
Agrichemicals such as herbicides, fungicides, insecticides, and biocides are widely used in agriculture, yet some are associated with adverse effects in humans and the environment. While many of these chemicals have been extensively studied...