Retrospective analysis of clinical laboratory parameters in Han Wistar rat controls [0.03%]
汉系Wistar大鼠对照组临床检验指标的回顾性分析
Rupert Kellner,Alexander Amberg,Frank Bringezu et al.
Rupert Kellner et al.
Introduction: Despite the availability of control animal data sets from toxicological studies, the influence of external factors, such as age of animals, test site and study conditions, on clinical laboratory parameters i...
Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review [0.03%]
人多能干细胞体外培养进展、挑战及展望：综合述评
Niraj Chaudhary,Luis G Villa-Diaz
Niraj Chaudhary
The advancement of human pluripotent stem cell (hPSC) culture systems has revolutionized the landscape of preclinical drug discovery and toxicological evaluation. Progressing innovations from feeder-dependent and xenogeneic matrices to chem...
Unseen contaminants in Portuguese reservoirs: linking microplastics to ecological potential and human pressures [0.03%]
葡萄牙水库中的隐形污染物：微塑料与生态潜力和人类压力的关系
C Guimarães,I Pinto,J A Padilha et al.
C Guimarães et al.
The accumulation of microplastics (MPs) in aquatic environments is a contemporary concern of great relevance, however, freshwater ecosystems, particularly reservoirs, have received less attention. This study evaluates the MPs in Rabagão an...
Hazard identification and characterization of leachable chemicals from plastic products - a new PARC project [0.03%]
塑料产品中迁移出的化学品的风险评估与特征定性-一个新的PARC项目
Hubert Dirven,Aleksandra Bogusz,Hans Bouwmeester et al.
Hubert Dirven et al.
A recent study has suggested that plastics may contain more than 16,000 chemicals, including additives, processing aids, starting substances, intermediates and Non-Intentionally Added Substances. Plastic chemicals are released throughout th...
AlCl3 exposure induces nephrotoxicity in mice by mediating ferroptosis through the NRF2 signaling pathway [0.03%]
AlCl3通过调节NRF2信号途径介导铁死亡诱导小鼠肾毒性
Liu-Dan Liang,Xiao-Yue Zhao,Li Li et al.
Liu-Dan Liang et al.
Aluminum is toxic to both humans and animals. Exposure to AlCl3 can lead to kidney function damage, yet the specific underlying mechanism remains elusive. This study aimed to investigate whether ferroptosis is involved in the renal toxicity...
Cadmium and glyphosate jointly compromise sperm function, fertilization, and early development in Prochilodus magdalenae [0.03%]
镉和草甘膦联合损害Prochilodus magdalenae精子功能、受精及早期发育
Jose Espinosa-Araujo,Lucellys Sierra-Marquez,Victor Atencio-Garcia et al.
Jose Espinosa-Araujo et al.
Cadmium (Cd) and glyphosate (Gly) are widespread aquatic contaminants known to impair reproductive function in freshwater fish. This study evaluated the effects of Cd, Gly, and their combined exposure on sperm quality and fertilization succ...
Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis [0.03%]
内分泌干扰奖赏：双酚A诱导的生殖毒性和药前期研究中黄酮类化合物的精准改善潜力。系统评价和荟萃分析
Michael Ben Okon,Ilemobayo Victor Fasongbon,Dominic Swase et al.
Michael Ben Okon et al.
Introduction: Bisphenol A (BPA), a pervasive endocrine-disrupting chemical, impairs male reproductive health via oxidative stress, hormonal dysregulation, and hypothalamic-pituitary-gonadal (HPG) axis disruption. Flavonoi...
Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries [0.03%]
吸入超细长颗粒物的鼻脑转运：已知和未知的事实
U M Graham,J M Pinto,J Weuve et al.
U M Graham et al.
In this study, we report that inhaled nanosized elongated mineral particles (EMPs) reach the human central nervous system (CNS) via two neuronal pathways, cranial nerve I (olfactorius) and cranial nerve V (trigeminus), from deposits on the ...
A new type of ultrasonic water alleviates constipation with favorable safety [0.03%]
一种新型超声波水可有效缓解便秘且安全性好
Jiarong Hu,Xinyi Hu,Wenjie Huang et al.
Jiarong Hu et al.
Introduction: Ultrasonic water (UW) is a novel category of functional drinking water. This study aimed to investigate its laxative efficacy and underlying mechanisms using a constipation model in SD rats, while also condu...
Su-Jun Fang,Zhao-di Yin,Li-Fan Li et al.
Su-Jun Fang et al.
Microplastic (MP) and nanoplastic (NP) pollution represents a pervasive environmental issue, raising significant concerns regarding potential neurotoxicity and impacts on brain health. This review synthesizes recent research findings to pro...