Role of bisphenol A in the aberrant activation of ionotropic glutamate transporters in the cerebral cortex and altered behavioral responses in C57BL/6J mice [0.03%]
双酚A对C57BL/6J小鼠大脑皮质离子型谷氨酸受体激活及行为反应的影响研究
Jasim Khan,Mohammad Waseem,Kajal Kamble et al.
Jasim Khan et al.
Bisphenol A (BPA) is a widely used endocrine-disrupting chemical that is used to manufacture epoxy resins and polycarbonate plastics. Dietary intake is considered the primary source of human exposure through leaching into food and beverages...
Combined lipid emulsion and plasma exchange in massive pediatric bupropion overdose: Case Report [0.03%]
丙咪嗪儿童中毒联合应用脂质注射液和血浆置换治疗：案例报告
Brett Russell,Michael Reedy,Kristina M Flathers et al.
Brett Russell et al.
Introduction: Massive bupropion overdose in pediatric patients can result in refractory cardiogenic shock, seizures, and cardiac arrest requiring aggressive intervention. Although lipid emulsion (LE), therapeutic plasma e...
Beyond the amyloid hypothesis: leveraging human-centered complex in vitro models to decode Alzheimer's disease etiology [0.03%]
超越淀粉样蛋白假说：利用人类导向的复杂体外模型解码阿尔茨海默病病因学
Matthew Price,Francesca Pistollato
Matthew Price
Alzheimer's disease (AD) is a complex neurodegenerative condition and the leading cause of dementia worldwide. Treatments that safely and effectively counteract disease progression are currently lacking. While the formation of amyloid plaqu...
Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development [0.03%]
妊娠和哺乳期间接触短链PFAS会改变成年后的学习记忆能力：可能与大脑发育相关机制有关
Luca Lorenzini,Marzia Moretti,Claudia Zanardello et al.
Luca Lorenzini et al.
Introduction: Exposure to long-chain perfluoroalkyl substances (PFASs) during development has been consistently associated with cognitive impairment and behavioural changes in humans. These concerns have led to regulatory...
Comparative assessment of solvents toxicity using early life stages of amphibians and cell lines: a case study with dimethyl sulfoxide [0.03%]
利用两栖动物早期生命阶段和细胞系评估溶剂的毒性：二甲亚砜的案例研究
Sónia Dias Coelho,Diana Campos,Mónica Almeida et al.
Sónia Dias Coelho et al.
The reduction in the number of animals being used in experimental assays has been a concern of the scientific community. In this sense, non-animal alternative methods have been increasingly tested. This study intended to explore how cell-ba...
Effects of atrazine on the HPG and HPA axes and steroidogenic pathways in females: relevance to reproductive function and breast, ovarian and uterine cancer [0.03%]
阿特拉津对女性HPG轴、HPA轴和类固醇生成途径的影响及其与生殖功能及乳腺癌、卵巢癌和子宫内膜癌的关系
Ralph L Cooper,James W Simpkins,Charles Breckenridge
Ralph L Cooper
We reviewed the mode of action (MOA) underlying the effect of the chlorotriazines on female reproduction and mammary tumor development in rats. Age-associated changes in the HPO hormonal environment of the female drive the development of ma...
Imidacloprid exposure in rats induces cardiac inflammatory response through activating TLR4/NF-κB/NLRP3 and JAK/STAT signaling pathways: focus on the berberine-loaded nanoliposomes [0.03%]
噻虫嗪通过激活TLR4/NF-κB/NLRP3和JAK/STAT信号通路诱导大鼠心脏炎症反应：小檗碱载药纳米脂质体的关注点
Layla Alkharashi,Amina A Farag,Noha M Gamil et al.
Layla Alkharashi et al.
The neonicotinoid insecticide, imidacloprid (IMI), is one of the widely used pesticides with well-documented serious health effects that are noticeable with long-term exposure. However, the long-term effects of IMI on cardiac tissues have n...
Astragaloside IV ameliorates atrazine-induced male reproductive toxicity: an in vivo and in silico analysis [0.03%]
Astragaloside IV改善阿特拉津诱导的雄性生殖毒性：体内和体外分析
Srinivasa Rao Sirasanagandla,Mohamed Al Mushaiqri,Firas Al-Majrafi et al.
Srinivasa Rao Sirasanagandla et al.
Introduction: Atrazine (ATZ) stands as the most widely utilized herbicide globally and is known for its adverse impacts on the reproductive system. Although astragaloside IV (AS IV) is well known for possessing various he...
Beyond cytotoxicity: pollutant mixtures elicit unconventional epithelial-fibroblast signaling in a human lung air-liquid interface co-culture model [0.03%]
超越细胞毒性：污染物混合物在人肺空气-液体界面共培养模型中诱发非传统的上皮成纤维细胞信号转导
Justine Fredoc-Louison,Maëva Cherrière,Bastien Rival et al.
Justine Fredoc-Louison et al.
Introduction: Combined exposures to airborne nanoparticles and acidic gases are plausible during industrial accidents and in military settings involving propellants. Aluminum oxide nanoparticles (Al2O3 NPs), widely used i...
Junwoo Park,Sujee Lee
Junwoo Park
Introduction: We introduce MoltiTox, a novel multimodal fusion model for molecular toxicity prediction, designed to overcome the limitations of single-modality approaches in drug discovery. ...