New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption - a PARC project [0.03%]
以内分泌干扰为重点的改进发育和生殖毒性(DART)评估的新方法论(NAMs)-来自PARC项目的研究
Jacob Ardenkjær-Skinnerup,Yoni Baert,Lola Bajard et al.
Jacob Ardenkjær-Skinnerup et al.
Endocrine disruptors (EDs) are implicated in adverse developmental and reproductive outcomes, yet their identification remains a major challenge in chemical safety assessment. Current testing strategies rely heavily on animal models, which ...
Jessica S Kopew,Merel Ritskes-Hoitinga,Mikalah Singer et al.
Jessica S Kopew et al.
Peer review aims to ensure that high-quality research is funded, conducted, and disseminated. However, peer review bias limits this process by violating impartiality, allowing factors other than merit to influence reviewers' judgment. Anima...
Nicotine-free electronic vape fluid stimulates angiogenic processes in vitro through ARF6-mediated oxidative stress [0.03%]
无尼古丁的电子烟油通过ARF6介导的氧化应激刺激体外血管生成过程
Lewis Spurrier-Best,David Butcher,Evangelene Blackham-Hayward et al.
Lewis Spurrier-Best et al.
Introduction: The increase in e-cigarette use in the population has led to substantial interest in the health impacts associated with e-cigarette smoking. E-cigarette smoking represents a key external environmental cell s...
Risk assessment of metals measured in regulated Canadian dried cannabis and cannabis vaping products: case study and perspectives [0.03%]
基于加拿大管制干大麻和大麻蒸气产品的金属检测结果开展风险评估：案例研究与展望
Sathish Achuthan,Andrew Waye,Hanan Abramovici
Sathish Achuthan
In 2018, the Cannabis Act and its regulations established a strict legal framework for controlling production, distribution, sale and possession of cannabis across Canada. At that time, smoking dried cannabis was the most prevalent mode of ...
A user-informed perspective of the toxicological data gap in India's cannabis landscape [0.03%]
印度大麻领域的毒理学数据缺口的用户视角
Muzafar Riyaz
Muzafar Riyaz
Clinical research on cannabinoids relies on purified compounds and controlled dosing, creating a data gap that ignores the realities of illicit markets. This perspective, informed by thirteen years of firsthand experience within India's pro...
Testicular mitochondrial redox imbalance and impaired oxidative phosphorylation underlie microplastic-induced testicular dysfunction in Wistar rats [0.03%]
微塑料通过引起大鼠睾丸线粒体氧化还原失衡和呼吸链功能障碍诱导睾丸损伤
Samuel Abiodun Kehinde,Tolulope Peter Fatokun,Sarva Mangala Praveena et al.
Samuel Abiodun Kehinde et al.
Polyethylene microplastics (PE-MPs), now pervasive environmental contaminants, have been implicated in reproductive toxicity, but their mechanistic effects on testicular function remain poorly defined. This study investigates the mechanisti...
The lack of efficacy of tirzepatide in mitigating cisplatin-induced neurotoxicity and cognitive impairment in rats [0.03%]
Tirzepatide对缓解大鼠顺铂诱发的神经毒性和认知障碍无效
Hanan Mubarak Almutairi,Ahmad Hamad Alhowail
Hanan Mubarak Almutairi
Introduction: Cisplatin (CIS) is a commonly utilized chemotherapeutic agent, but its use is often accompanied by adverse effects such as neurotoxicity and cognitive impairments, collectively referred to as chemobrain. Thi...
The zebrafish in toxicology: a bibliometric analysis reveals current trends and future avenues for predictive safety assessment [0.03%]
毒理学中的斑马鱼：基于文献计量分析揭示预测安全性评估的当前趋势及未来方向
Carla Lima,Darlan Gusso,Geonildo Rodrigo Disner et al.
Carla Lima et al.
The zebrafish (Danio rerio) has become an indispensable model in toxicological research, bridging environmental monitoring, disease modeling, and preclinical drug screening. This study presents a comprehensive bibliometric and methodologica...
Food contaminants: mechanisms of toxicity, computational assessment, and mitigation [0.03%]
食品安全：毒理机制、计算评估及缓解方法
Laura Escorihuela,Rajesh Kumar Pathak,Benjamí Martorell et al.
Laura Escorihuela et al.
Understanding the toxicological mechanisms of food contaminants is critical for assessing risks to human health. This review comprehensively examines their adverse effects, tracing the pathway from molecular initiation to systemic organ-lev...
Bridging science and curriculum: preparing future leaders in computational toxicology [0.03%]
计算毒理学未来领军人才的培养：从科学到课程的设计与实施
Frances Hall,Candice Johnson
Frances Hall
Computational toxicology plays an important role in chemical safety assessments. Computational methods are applied to early-stage screening in drug discovery, hazard identification, and regulatory safety assessment. This article presents an...