Effect of the cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on in vivo platelet activation, oxidative stress, and procoagulant responses induced by waterpipe smoke exposure in mice [0.03%]
L-2-氧噻唑烷-4-羧酸对水烟烟雾暴露小鼠体内血小板活化、氧化应激和促凝血反应的影响
Sumaya Beegam,Nur E Zaaba,Ozaz Elzaki et al.
Sumaya Beegam et al.
Introduction: Exposure to waterpipe smoke (WPS) in humans and experimental animals has been reported to cause oxidative stress and thrombotic complications. L-2-Oxothiazolidine-4-carboxylic acid (OTC) is a cysteine prodru...
Use of gastroscopy in the management of pediatric toxic ingestions: insights from a decade of experience - a retrospective study [0.03%]
胃镜在儿童中毒暴露管理中的应用：十年回顾性研究经验启示
Marco Marano,Lavinia Di Meglio,Mara Pisani et al.
Marco Marano et al.
Objective: Pediatric poisonings account for a significant proportion of poison center consultations. Gastrointestinal decontamination (GD) is a crucial intervention in cases of acute poisoning, yet its effectiveness remai...
Evaluating chemotherapy-driven placental alterations and their impact on fetal development [0.03%]
化疗引起的胎盘改变及其对胎儿发育的影响评估
Katrien De Clercq,Carolina Velazquez,Eleonora Persoons et al.
Katrien De Clercq et al.
Background: Chemotherapy during pregnancy presents a clinical challenge, balancing maternal treatment efficacy with fetal safety. While chemotherapy after the first trimester is generally considered safe, its impact on pl...
Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells [0.03%]
微塑料会放大真菌菌丝片段和孢子引起的类中性粒细胞的促炎反应
Anani K Afanou,Andreas Solberg Sagen,Francesco Barbero et al.
Anani K Afanou et al.
Background: Microplastic pollution has emerged as a global environmental crisis with potential adverse consequences on human health. Mixtures of microplastics with fungal particles including mycelial fragments or spores a...
From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round [0.03%]
从优先排序到落实：通过第二轮优先排序更新PARC工作计划第五部分项目组合
Celia Garcia Arenas,Kiara Aiello Holden,Terje Svingen et al.
Celia Garcia Arenas et al.
The Partnership for the Assessment of Risks from Chemicals (PARC) represents a joint effort among risk assessors, regulatory authorities, and the scientific community to advance the implementation of next-generation risk assessment (NGRA) i...
Microplastic toxicity: mechanisms, assessment methods, and future research directions [0.03%]
微塑料毒性：机制、评估方法及未来研究方向
Yifan Zhang,Jiale Ren,Binying Zheng et al.
Yifan Zhang et al.
Microplastics (MPs), plastic particles under 5 mm in diameter, represent a pervasive and persistent global environmental contaminant with cascading adverse effects on aquatic/terrestrial organisms and human health. While existing reviews ha...
Clinical features of toxic encephalopathy induced by 1,2-dichloroethane [0.03%]
1,2-二氯乙烷所致中毒性脑病的临床特征
Yuquan Chen,Yuqiang Lin,Yifan Ye et al.
Yuquan Chen et al.
Introduction: 1,2-Dichloroethane (1,2-DCE) is a highly toxic industrial organic solvent that can cause acute toxic encephalopathy through occupational exposure, with underreported clinical data in English literature. To e...
A case report of arsenic-induced peripheral neuropathy misdiagnosed as Guillain-Barré syndrome [0.03%]
误诊为吉兰-巴雷综合征的砷周围神经病病例报告
Shanshan Fu,Guanao Wu,Yibo Zhan et al.
Shanshan Fu et al.
Objective: To explore the clinical characteristics and misdiagnosis causes of arsenic-induced peripheral neuropathy. Methods: We report...
Foreign body reaction: towards a macrophage-centered adverse outcome pathway for fibrotic encapsulation [0.03%]
异物反应：纤维囊性包被不良预后的巨噬细胞中心模式
Tom Meseberg,Susanne Kurz,Juliane Spohn
Tom Meseberg
The foreign body reaction (FBR), characterized by chronic inflammation and fibrotic capsule formation around implanted medical devices, remains a major cause in device-related complications. Current preclinical risk assessment relies on in ...
Multi-task deep learning models for mechanism-based prediction of developmental and reproductive toxicity (DART) using ToxCast bioassays [0.03%]
基于机制的发育和生殖毒性(DART)预测的多任务深度学习模型(使用ToxCast生物测定法)
Siyeol Ahn,Hojun Jung,Jinwon Hwang et al.
Siyeol Ahn et al.
Developmental and reproductive toxicity (DART) testing has traditionally relied on animal studies, which are costly, time-consuming, and ethically constrained. To advance new approach methodologies (NAMs), we developed a mechanism-informed ...