Acetaldehyde and methylglyoxal: comparative analysis of toxic electronic cigarette degradation products in 3D and 2D exposure systems using human bronchial epithelial models [0.03%]
乙醛和甲基glyoxal：使用人体支气管上皮模型在三维和二维暴露系统中比较分析有毒的电子烟降解产物
Man Wong,Teresa Martinez,Nathan Hendricks et al.
Man Wong et al.
Background: Acetaldehyde and methylglyoxal are structurally related aldehydes produced by thermal degradation of the electronic cigarette (EC) solvents, propylene glycol and glycerin. Despite their presence in EC aerosols...
In Vitro analysis of the effect of mono-(2-ethylhexyl) phthalate (MEHP) exposure on macrophage inflammatory responses in relationship to Leydig cell steroid production [0.03%]
体外分析单(2-乙基己基)邻苯二甲酸酯(MEHP)暴露对巨噬细胞炎症反应与支持Leydig细胞类固醇产生的关系的影响分析
Akhil Adla,Allison Lunney,Barry Zirkin et al.
Akhil Adla et al.
Macrophages, essential components of the innate immune system, are considered to be involved in the regulation of Leydig cell steroidogenesis, though by mechanisms that remain uncertain. Mono-(2-ethylhexyl) phthalate (MEHP), the active meta...
Excessive alcohol consumption: a driver of metabolic dysfunction and inflammation [0.03%]
饮酒过量：代谢紊乱和炎症的诱因
Jaeeun Lee,Ji-Young Lee,Hyunju Kang
Jaeeun Lee
With the increasing prevalence of alcohol-related diseases, expanding our understanding of the toxic effects of excessive alcohol consumption is critical for prevention and treatment of metabolic and inflammatory pathology. This review summ...
Implementing a trilineage differentiation in the ReproTracker assay for improved teratogenicity assessment [0.03%]
在ReproTrack测定中实施三系分化以改善致畸性评价
José M Horcas-Nieto,Sabine Hartvelt,Luke Flatt et al.
José M Horcas-Nieto et al.
Introduction: Exposure to teratogenic compounds during pregnancy can lead to significant birth defects. Given the considerable variation in drug responses across species, along with the financial and ethical challenges as...
Forensic toxicology of benzodiazepines: neuropharmacological effects, analytical challenges, and emerging detection strategies [0.03%]
苯二氮卓类法医毒理学：神经药理学效应、分析挑战及新兴检测策略
Husna Irfan Thalib,Ahmed Abdelghany Damanhory,Ayesha Hanin Shaikh et al.
Husna Irfan Thalib et al.
The increasing misuse of benzodiazepines (BZDs) in drug-facilitated crimes (DFCs) has become a serious concern for forensic experts, healthcare professionals, and legal authorities. These drugs, which are commonly prescribed for anxiety and...
From genes to organs: physiological responses of European chub (Squalius cephalus) to chronic PFAS pollution [0.03%]
从基因到器官：全氟烷基和多氟烷基物质慢性污染对欧亚家卿生理响应的影响
Sara Pacchini,Laura Drago,Martina Cortese et al.
Sara Pacchini et al.
Per- and polyfluoroalkyl substances (PFAS) are widespread anthropogenic contaminants known to the scientific community for their persistence and toxicity. Our research aims to evaluate the effect of chronic environmental exposure to PFAS on...
Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system [0.03%]
微塑料的环境暴露途径及其对生态系统和神经系统的影响毒效应
Kuo Lu,Yixiang Que,Longfei Wang et al.
Kuo Lu et al.
Microplastics are a troubling consequence of modern civilization, permeating ecosystems worldwide and posing a risk to both the environment and human health. As studies have revealed their extensive distribution throughout bodies of water, ...
Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology [0.03%]
人源HepaRG细胞中基于高通量测序的错配修复位点定向遗传毒性检测及其在药物研发中的应用研究
A Rasim Barutcu,Nimisha Bhattarai,Raymond Samuel et al.
A Rasim Barutcu et al.
Human metabolically competent HepaRG™ (HepaRG) cells have been developed as a human-relevant New Approach Methodology (NAM) in genetic toxicology, providing a non-animal alternative to rodent-based mutagenicity testing following a positive...
Daflon and Centrum mitigate vancomycin-induced nephrotoxicity in rats by ameliorating oxidative stress, DNA damage, apoptosis, and inflammation [0.03%]
黛芬和中枢通过改善氧化应激、DNA损伤、凋亡和炎症来缓解万古霉素引起的肾毒性
Hanem F El-Gendy,Soaad Salamah,Eman Elhusseiny et al.
Hanem F El-Gendy et al.
Background: Vancomycin (VM) is widely used for treating life-threatening infections caused by Gram-positive bacteria resistant to other antibiotics. However, its nephrotoxic effects limit clinical use. ...
Mercury exposure leading to functional vitamin B12 deficiency and subacute combined degeneration: a case report and literature review [0.03%]
汞暴露导致的功能性维生素B12缺乏及亚急性联合变性的病例报道和文献回顾
Isidora Semnic,Valentino Rački,Olivia Perković et al.
Isidora Semnic et al.
Introduction: The association between neurological symptomatology and heavy metal exposure has been reported in the literature. A few cases of extrapyramidal symptomatology and subacute combined degeneration have been des...