Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate [0.03%]
由六异戊二烯焦磷酸衍生的新一类三萜的发现及分析
Dan Hu
Dan Hu
Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization...
Copper-radical oxidases: A diverse group of biocatalysts with distinct properties and a broad range of biotechnological applications [0.03%]
铜类酶：一类具有特殊性质和广泛生物技术应用前景的生物催化剂
Katja Koschorreck,Saadet Alpdagtas,Vlada B Urlacher
Katja Koschorreck
Copper-radical oxidases (CROs) catalyze the two-electron oxidation of a large number of primary alcohols including carbohydrates, polyols and benzylic alcohols as well as aldehydes and α-hydroxy-carbonyl compounds while reducing molecular ...
Yamei Gan,Xin Meng,Cong Gao et al.
Yamei Gan et al.
The increasing shortage of fossil resources and environmental pollution has renewed interest in the synthesis of value-added biochemicals from methanol. However, most of native or synthetic methylotrophs are unable to assimilate methanol at...
Genome-scale CRISPRi screening: A powerful tool in engineering microbiology [0.03%]
基因组规模的CRISPRi筛选技术：工程微生物学中的有力工具
Letian Sun,Ping Zheng,Jibin Sun et al.
Letian Sun et al.
Deciphering gene function is fundamental to engineering of microbiology. The clustered regularly interspaced short palindromic repeats (CRISPR) system has been adapted for gene repression across a range of hosts, creating a versatile tool c...
A recombineering system for Bacillus subtilis based on the native phage recombinase pair YqaJ/YqaK [0.03%]
基于固有噬菌体重组酶对YqaJ/YqaK的芽孢杆菌bsubtilis重组工程系统
Qingshu Liu,Ruijuan Li,Hongbo Shi et al.
Qingshu Liu et al.
Bacillus subtilis plays an important role in fundamental and applied research, and it has been widely used as a cell factory for the production of enzymes, antimicrobial materials, and chemicals for agriculture, medicine, and industry. Howe...
Engineering of Saccharomyces cerevisiae for co-fermentation of glucose and xylose: Current state and perspectives [0.03%]
用于葡萄糖和木糖联合发酵的酿酒酵母工程化研究：现状与展望
Yali Qiu,Meiling Wu,Haodong Bao et al.
Yali Qiu et al.
The use of non-food lignocellulosic biomass to produce ethanol fits into the strategy of a global circular economy with low dependence on fossil energy resources. Xylose is the second most abundant sugar in lignocellulosic hydrolysate, and ...
Recombineering enables genome mining of novel siderophores in a non-model Burkholderiales strain [0.03%]
利用基因组重建技术在非模式菌株Burkholderiales中挖掘新型铁载体
Xingyan Wang,Haibo Zhou,Xiangmei Ren et al.
Xingyan Wang et al.
Iron is essential for bacterial survival, and most bacteria capture iron by producing siderophores. Burkholderiales bacteria produce various types of bioactive secondary metabolites, such as ornibactin and malleobactin siderophores. In this...
Catalog of operational taxonomic units and unified amplicon sequencing data for the microbiomes of medicinal plant roots [0.03%]
中药植物根系微生物组的操作分类单元目录和统一扩增子测序数据
Meng Wang,Ming Lei,Hailun He
Meng Wang
China has a rich history of cultivating medicinal plants, whose root microbial communities closely interact with the medicinal plants, thereby influencing their growth, health, and medicinal properties. Currently, researchers widely use 16S...
Recent advances in the direct cloning of large natural product biosynthetic gene clusters [0.03%]
天然产物生物合成基因簇的直接克隆研究进展
Jiaying Wan,Nan Ma,Hua Yuan
Jiaying Wan
Large-scale genome-mining analyses have revealed that microbes potentially harbor a huge reservoir of uncharacterized natural product (NP) biosynthetic gene clusters (BGCs), and this has spurred a renaissance of novel drug discovery. Howeve...
The lasso structure, biosynthesis, bioactivities and potential applications of Microcin J25: A novel antibacterial agent with unique mechanisms [0.03%]
新型抗菌剂微链J25的结构、合成、活性及应用潜力研究进展
Qingchun Ji,Bixia Zhou,Tong Shen et al.
Qingchun Ji et al.
The overuse and misuse of traditional antimicrobial drugs have led to their weakened effectiveness and the emergence of pathogenic bacterial resistance. Consequently, there has been growing interest in alternative options such as antimicrob...