Cross-kingdom noncoding RNA regulation facilitates Nosema bombycis proliferation [0.03%]
跨界非编码RNA调控促进家蚕微孢子虫增殖
Pengcheng Zhang,Boyuan Deng,Wenxuan Fang et al.
Pengcheng Zhang et al.
Microsporidia are obligate intracellular fungal parasites that are widely distributed in natural and agricultural environments and represent an important biological hazard to economically important insects. Nosema bombycis (N. bombycis), th...
Random mutagenesis platform for accelerated genome evolution (RAMPAGE) of Pichia pastoris [0.03%]
应用于毕赤酵母的加速基因组进化的随机诱变平台（RAMPAGE）
Yingjia Pan,Xiaosong Gu,Binying Lv et al.
Yingjia Pan et al.
The biological conversion of methanol into valuable chemicals represents a promising route for achieving global carbon neutrality. However, the rational engineering of complex industrial traits in microbial cell factories is hindered by an ...
Enhancement of heat resistance of Bacillus thermoamylovorans drives enhanced PET degradation [0.03%]
解聚杆菌热耐受性的增强促进了聚对苯二甲酸乙二醇酯降解性能的提升
Yi-Mei Cai,Kang-Qi Hu,Xin-Yu Zhang et al.
Yi-Mei Cai et al.
Microbial polyethylene terephthalate (PET) degradation has emerged as an environmentally friendly approach to reducing plastic pollution, but microbial activity is often limited by the high temperatures (60-70 °C) required for efficient de...
Engineering host‑defense peptides enhanced by artificial intelligence and nano delivery systems to overcome biofilms and antimicrobial resistance [0.03%]
利用人工智能和纳米递送系统改良宿主防御肽以克服生物膜和抗菌抗性
Raman Krishnamoorthi,Muthuramalingam Kaviyadharshini,Pambayan Ulagan Mahalingam et al.
Raman Krishnamoorthi et al.
Infections caused by bacteria pose a risk to humanity as drugs become increasingly ineffective as resistance to bacterial strains emerge along with biofilm and persister formation. This review critically evaluates host defense peptides, rat...
Structure-guided surface engineering to improve the catalytic activity of ethylene-forming enzyme [0.03%]
结构导向的表面工程可提高乙烯形成酶的催化活性
Mengyuan Wang,Zhuanglin Shen,Lian Wu et al.
Mengyuan Wang et al.
The ethylene-forming enzyme (EFE) is a member of the mononuclear non-heme Fe(II)- and 2-oxoglutarate-dependent oxygenase superfamily, which can oxidize 2-oxoglutarate to form ethylene in an arginine-dependent reaction. While significant enz...
Prospects and challenges in using engineered lactic acid bacteria in aquaculture applications [0.03%]
工程乳酸菌在水产养殖应用中的机遇与挑战
Xiyin Huang,Xiangze Sun,Xingya Dong et al.
Xiyin Huang et al.
Despite the considerable potential of lactic acid bacteria (LAB) as probiotics, there is a fundamental gap between the functional limitations of wild-type strains and the complex demands of aquaculture. Modular and intelligent engineering s...
Fangyuan Wu,Tianyu Dong,Qi Gao et al.
Fangyuan Wu et al.
3-Carene is a bicyclic monoterpene with a pine aroma. It is widely used as a flavoring agent, food additive, and insecticide in food and agricultural applications. Therefore, establishing an efficient microbial pathway for 3-carene is impor...
Herbal extracts as antibiotic adjuvants against ESKAPE pathogens: mechanisms and therapeutic potential [0.03%]
草药提取物作为对抗ESKAPE病原体的抗生素辅助药物：机制和治疗潜力
Hanlin Ma,Jing Wang,Fengyu Zhang et al.
Hanlin Ma et al.
The escalating crisis of antimicrobial resistance, particularly driven by ESKAPE pathogens, poses a serious threat to global public health. With the stagnant pipeline of novel antibiotic discovery, repurposing herbal extracts as antibiotic ...
Actinobacteria TFDB: An integrated view of transcription factors in Actinobacteria [0.03%]
放线菌转录因子数据库：放线菌转录因子的全面分析视图
Yu Fu,Zhan-Hui Xu,Yi-Fan Liang et al.
Yu Fu et al.
Actinobacteria represent a prolific source of bioactive natural products. However, the complex transcriptional regulatory networks in these bacteria, particularly the interplay between transcription factors (TFs) and their regulatory ligand...
Genome-guided discovery of tropansamycins: antimicrobial pentaketide ansamycins [0.03%]
基因组导向的隐酮链霉菌抗生素隐酮素类化合物的研究与发现
Haotian Wang,Run Jiao,Liran Ma et al.
Haotian Wang et al.
Although ansamycins are clinically important macrolactams, their pentaketide subset exhibits limited biological activities. Genome mining of rhizosphere-derived Streptomyces sp. LR53 uncovered a cryptic pentaketide ansamycin gene cluster (t...