Systems metabolic engineering of glutathione biosynthesis in Saccharomyces cerevisiae: Pathway balancing coupled with enzyme screening for high-titer production [0.03%]
谷胱甘肽生物合成的系统代谢工程：通过平衡途径与筛选高滴度酶实现Saccharomyces cerevisiae的高效生产
Zhiqi Hu,Mengyuan Su,Qibing Liu et al.
Zhiqi Hu et al.
Glutathione (GSH), an essential tripeptide thiol critical for cellular redox regulation, has significant value in the pharmaceutical and nutraceutical industries. To overcome limitations of traditional GSH extraction methods, this study est...
Identification and functional characterization of a potential l-Homoserine exporter in Corynebacterium glutamicum [0.03%]
天冬氨酸棒杆菌潜在的l-同型丝氨酸出口蛋白鉴定及功能表征
Xiaodi Liu,Xiangyu Zhu,Wenxin Jiang et al.
Xiaodi Liu et al.
Exporter protein systems play a crucial role in the efficient production of valuable chemicals. However, the lack of active exporters significantly limits the application of industrial bio-based production, making the identification and uti...
Bifidobacterium animalis subsp. lactis genome resources and metabolite profiling at the strain level and their ability to alleviate anxiety-like behavior in a sleep-deprived mouse model [0.03%]
嗜动物乳双歧杆菌菌株水平基因组资源和代谢轮廓及其在睡眠剥夺的小鼠模型中缓解类似焦虑行为的能力
Yao-Kun Zhang,Liang Zhang,Xue Ni et al.
Yao-Kun Zhang et al.
Bifidobacterium animalis subsp. lactis is a well-known probiotic with potential benefits for alleviating sub-health symptoms, including immune dysfunction and anxiety. Given the strain-specific nature of its probiotic effects, identifying e...
Decoupling growth phase dependency and metal ion inhibition: A dual engineering strategy for the high-yield biosynthesis of microcin J25 in Escherichia coli [0.03%]
解耦生长阶段依赖性和金属离子抑制作用：大肠杆菌中高产生物合成微菌素J25的双工程策略
Guangxin Yang,Xinchan Wang,Yunting Zhou et al.
Guangxin Yang et al.
Microcin J25 (MccJ25) has received substantial attention as a potential solution to the global threat of infection caused by antibiotic-resistant bacteria. However, the industrial fermentation of MccJ25 faces production bottlenecks. It is i...
Electricity generation and dibenzothiophene biodegradation using a novel electroactive bacterium Lysinibacillus macroides AP in microbial fuel cells [0.03%]
用电活性菌Lysinibacillus macroides AP产生电力并降解二苯并噻吩的微生物燃料电池研究
Zihan Huang,Lei Zhang,Ting Cai et al.
Zihan Huang et al.
Polycyclic aromatic sulfur heterocycles, such as dibenzothiophene (DBT), and their alkylated derivatives are recognized as persistent and toxic contaminants that pose major risks to the environment and human health. Here, a novel electroact...
Diversity analysis of phytase-producing bacteria from coastal seawater and sediment and characterization of their phytases [0.03%]
来自沿海海水和沉积物产植酸酶细菌的多样性分析及其植酸酶的性质研究
Xiao-Jie Yuan,Rui Liu,Jian Li et al.
Xiao-Jie Yuan et al.
Phytic acid, also known as inositol hexaphosphate (IP6), is one of the most abundant organophosphorus compounds in nature. Its degradation by phytase plays a key role in the natural phosphorus cycle. In addition, phytases are widely used in...
Unraveling microbial life from a high-altitude hydrothermal system in the Andes plateau and their potential for nitrogen transformations [0.03%]
安第斯山脉高原热液系统中微生物的解谜及其潜在的氮转化作用
Coral Pardo-Esté,Juan Castro-Severyn,Jacqueline Aldridge et al.
Coral Pardo-Esté et al.
Terrestrial hydrothermal systems provide a window for studying the biogeochemical interactions that occur in hot and gas-rich ecosystems resembling the conditions found in early life on Earth. The biogeochemical dynamics of the Andean hydro...
Erratum to "Regulation of protein thermal stability and its potential application in the development of thermo-attenuated vaccines" [Engineering Microbiology 4 (2024) 100162] [0.03%]
关于“蛋白质热稳定性的调控及其在热减毒疫苗开发中的潜在应用”的勘误[工程微生物学 4 (2024) 100162]
Maofeng Wang,Cancan Wu,Nan Liu et al.
Maofeng Wang et al.
[This corrects the article DOI: 10.1016/j.engmic.2024.100162.]. © 2025 The Authors.
Published Erratum
Engineering microbiology. 2025 Mar 25;5(2):100204. DOI:10.1016/j.engmic.2025.100204 2025
Engineering thermotolerant microbial strains via TrRCC1 overexpression for efficient bioethanol production [0.03%]
通过TrRCC1过表达工程耐热微生物菌株高效生产燃料乙醇
Tingting Chen,Xiao He,Xinyan Zhang et al.
Tingting Chen et al.
Efficient conversion of corn stover to bioethanol via simultaneous saccharification and fermentation (SSF) is a promising strategy for sustainable biofuel production. A major current barrier to this process is the limited thermotolerance of...
Cytochrome P450-catalyzed allylic oxidation of pentalenene to 1-deoxypentalenic acid in pentalenolactone biosynthesis [0.03%]
五味子 lactone生物合成中细胞色素P450催化的戊烯炔醇氧化为1-脱氧戊烯酸𬭩离子𬭩离子
Jing Li,Chengde Zhang,Shiwen Wu et al.
Jing Li et al.
Pentalenolactone is a sesquiterpene antibiotic from Streptomyces. Its biosynthetic pathway has been elucidated, except for the oxidation of pentalen-13-al to 1-deoxypentalenic acid. In this study, we show that cytochrome P450 pentalenene ox...