Carotenoid productivity in human intestinal bacteria Eubacterium limosum and Leuconostoc mesenteroides with functional analysis of their carotenoid biosynthesis genes [0.03%]
人体肠道细菌粪产碱菌和肠链球菌的类胡萝卜素产量及其类胡萝卜素生物合成基因的功能分析
Wataru Matsumoto,Miho Takemura,Haruka Nanaura et al.
Wataru Matsumoto et al.
The human intestinal microbiota that comprise over 1,000 species thrive in dark and anaerobic environments. They are recognized for the production of diverse low-molecular-weight metabolites crucial to human health and diseases. Carotenoids...
Altered interaction network in the gut microbiota of current cigarette smokers [0.03%]
吸烟者肠道微生物群的交互作用网络发生变化
Zhouhai Zhu,Meng Wang,Ying Guan et al.
Zhouhai Zhu et al.
The association between cigarette smoking and the gut microbiota remains unclear, and there is no agreement on how smoking affects the composition of gut microorganisms. In this study, the relationship between smoking status and gut microbi...
Greener approach to the comprehensive utilization of algal biomass and oil using novel Clostridial fusants and bio-based solvents [0.03%]
利用新型芽孢杆菌融合菌株和生物基溶剂实现藻类生物质及藻油的绿色高效转化与利用
Asma Fiayaz,Yaser Dahman
Asma Fiayaz
A greener method has been tested to utilize algal biomass as a feedstock to produce bio-oil in addition to acetone, butanol, and ethanol (ABE) products. Various hydrolysis treatments were used prior to fermentation including combination of ...
Wensheng Qin,Guodong Liu
Wensheng Qin
Jianzhong Lin,Yunxue Guo,Jianyun Yao et al.
Jianzhong Lin et al.
Toxin-antitoxin (TA) systems are ubiquitous in bacteria and archaea. Most are composed of two neighboring genetic elements, a stable toxin capable of inhibiting crucial cellular processes, including replication, transcription, translation, ...
Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism [0.03%]
操纵子工具在黏细菌中用于开发次级代谢产物
Xinjing Yue,Duohong Sheng,Li Zhuo et al.
Xinjing Yue et al.
Myxobacteria are famous for their capacity for social behavior and natural product biosynthesis. The unique sociality of myxobacteria is not only an intriguing scientific topic but also the main limiting factor for their manipulation. After...
A highly selective cell-based fluorescent biosensor for genistein detection [0.03%]
一种用于检测染料木黄酮的高选择性细胞荧光生物传感器
Lucy Fang-I Chao,Dany Liu,Verena Siewers
Lucy Fang-I Chao
Genistein, an isoflavone found mainly in legumes, has been shown to have numerous health benefits for humans. Therefore, there is substantial interest in producing it using microbial cell factories. To aid in screening for high genistein pr...
High-level production of γ-aminobutyric acid via efficient co-expression of the key genes of glutamate decarboxylase system in Escherichia coli [0.03%]
通过谷氨酸脱羧酶系统关键基因高效共表达在大肠杆菌中高水平生产γ-氨基丁酸
Lili Yao,Changjiang Lyu,Yuting Wang et al.
Lili Yao et al.
Biosynthesis of the functional factor γ-aminobutyric acid (GABA) in bacteria involves two key proteins an intracellular glutamate decarboxylase (GadB) and a membrane-bound antiporter (GadC). Efficient co-expression of suitable GadB and Gad...
CRISPRi screen highlights chromatin regulation to be involved in formic acid tolerance in Saccharomyces cerevisiae [0.03%]
基于CRISPR干扰的筛选揭示了染色质调控参与酿酒酵母耐甲酸性
Vaskar Mukherjee,Ibai Lenitz,Ulrika Lind et al.
Vaskar Mukherjee et al.
Formic acid is one of the main weak acids in lignocellulosic hydrolysates that is known to be inhibitory to yeast growth even at low concentrations. In this study, we employed a CRISPR interference (CRISPRi) strain library comprising >9000 ...
Hang Li
Hang Li
Biosynthetic pathways without any identifiable core enzymes may encode unknown (biosynthetic route)-unknown (molecular structure) natural products. However, bioinformatics-guided mining for such unknown-unknown metabolites is challenging. R...