Genotypic and molecular characterization of a moderately thermophilic cyanobacterium, Gloeocapsa sp. strain BRSZ [0.03%]
低温热聚球藻BRSZ菌株的基因型和分子特征研究
Sasiprapa Samsri,Tanwalee Deprom,Chananwat Kortheerakul et al.
Sasiprapa Samsri et al.
A unicellular-colonial cyanobacterium, designated "BRSZ," was isolated from a neutral-alkaline hot spring in Thailand. Morphological characterization revealed distinctive features consistent with those of the genus Gloeocapsa. Physiological...
A novel therapeutic strategy of methicillin-resistant Staphylococcus aureus [0.03%]
一种耐甲氧西林金黄色葡萄球菌的新疗法策略研究
Ying Wang,Mengyan Xu,Hanne Ingmer
Ying Wang
Staphylococcus aureus is a major public health threat, largely due to its remarkable capacity to develop antimicrobial resistance. Zhang et al. recently demonstrated a highly innovative approach to eradicate chronic methicillin-resistant S....
Analysis of single-cell RNA sequencing data to examine the gastric inflammation-to-cancer transition and evaluation of the effect of probiotic on precancerous lesions [0.03%]
单细胞RNA测序数据分析胃炎癌变过程及益生菌对癌前病变影响的评估
Minmin Hu,Shiyang Xu,Ruofei Xu et al.
Minmin Hu et al.
Gastric cancer (GC) is the fifth most prevalent malignancy globally. However, its heterogeneity and asymptomatic early-stage development hinder timely diagnosis and effective treatment. Here, we employed single-cell RNA sequencing to deline...
Jingxian Zhang,Peng Xu,Yongjun Wei
Jingxian Zhang
Cycloastragenol is a bioactive, high-value triterpenoid derived from Astragalus membranaceus. Conventional plant-based extraction and chemical synthesis methods are expensive. To our knowledge, this is the first report on the de novo biosyn...
Chenghao Ma,Jingxi Liu,Hongjing Liu et al.
Chenghao Ma et al.
As the understanding of bacteria-mediated cancer therapies deepens, bacteria such as Escherichia coli Nissle 1917 (EcN) have become a promising platform for cancer therapy. However, their potential role in real-time monitoring and visualiza...
The role of microbiota dysbiosis in Parkinson's disease: Pathophysiology and therapeutic opportunities [0.03%]
帕金森病中菌群失调的作用：病理生理及治疗机会
Shabnam Santos,Ivonne Salinas,Nicolás Almeida et al.
Shabnam Santos et al.
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder characterized by debilitating motor and non-motor symptoms. Its etiology is multifactorial, with no single definitive cause identified, although aging is a signif...
Screening of molecular elements and improvement of heat resistance in a thermophilic bacterium [0.03%]
耐热细菌的耐热性改善及其分子要素的筛选
Jie Cui,Caifeng Li,Gongze Cao et al.
Jie Cui et al.
Engineering microorganisms to withstand extreme temperatures (>80 °C) remains a critical challenge in industrial biotechnology owing to limited genetic tools and poor mechanistic understanding of microbial thermoadaptation. We aimed to dev...
Production of dicarboxylates from ω-amino acids using a cofactor- and co-substrate-free in vitro biosynthetic system [0.03%]
一种不含辅因子和辅助底物的体外生物合成体系用于生成二羧酸类化合物
Jinxin Yan,Hui Zhang,Hongxu Zhang et al.
Jinxin Yan et al.
Dicarboxylates are valuable platform compounds with a broad range of applications. The in vitro biosynthetic system used to produce dicarboxylates from ω-amino acids via the natural pathway requires costly cofactors and co-substrates, whic...
Archaeasins as a promising resource for developing next-generation antibiotics uncovered via deep learning [0.03%]
通过深度学习发现产抗生素考古念珠菌属——下一代抗生素的前景资源
Huan Du,Yang Liu
Huan Du
Fighting against antibiotic resistance has an unexpected ally, archaea. Despite the extensive exploration of antimicrobial peptides in bacteria and eukaryotes, the archaeal domain has been overlooked. A recent study employed deep learning t...
Yingbo Yuan,Tianyuan Su,Yi Zheng et al.
Yingbo Yuan et al.
Polystyrene (PS) is a polyolefin plastic that is used extensively in food packaging. The chemical structure of PS is extremely stable owing to its C-C backbone and styrene rings, making it highly resistant to biodegradation, which causes se...