Mechanisms of tigecycline resistance in Gram-negative bacteria: A narrative review [0.03%]
替加环素耐药革兰阴性菌的耐药机制：综述
Wenya Su,Wenjia Wang,Ling Li et al.
Wenya Su et al.
Tigecycline serves as a critical "final-resort" antibiotic for treating bacterial infections caused by multidrug-resistant bacteria for which treatment options are severely limited. The increasing prevalence of tigecycline resistance, parti...
CRISPR-Cas9-based genome-editing technologies in engineering bacteria for the production of plant-derived terpenoids [0.03%]
基于CRISPR-Cas9的基因组编辑技术在工程化细菌生产植物来源萜类化合物中的应用
Xin Sun,Haobin Zhang,Yuping Jia et al.
Xin Sun et al.
Terpenoids are widely used as medicines, flavors, and biofuels. However, the use of these natural products is largely restricted by their low abundance in native plants. Fortunately, heterologous biosynthesis of terpenoids in microorganisms...
Dual role of phage terminase in Salmonella enterica oxidative stress response [0.03%]
噬菌体终止酶在沙门氏菌氧化应激反应中的双重作用
Senfeng Zhang,Shengsheng Ma,Feizuo Wang et al.
Senfeng Zhang et al.
The adaptive survival mechanisms of bacterial pathogens under host-induced stress are crucial for understanding pathogenesis. Recently, Uppalapati et al. revealed a unique dual function of the Gifsy-1 prophage terminase in Salmonella enteri...
Xuewen Hou,Ruonan Sun,Yanyan Feng et al.
Xuewen Hou et al.
Peptaibols are a large family of linear, amphipathic polypeptides consisting of 5-20 amino acid residues generated from the fungal nonribosomal peptide synthetase (NRPS) pathway. With a relatively high content of non-proteinogenic amino aci...
Yuxi Zhou,Yong Han
Yuxi Zhou
The development of drug delivery vehicles is in significant demand in the context of precision medicine. With the development of synthetic biology, the use of genetically engineered bacteria as drug delivery vectors has attracted more and m...
Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes [0.03%]
放线菌rubromycin的分离、生物合成及生物学活性研究
Ping Lin,Xue Li,Yuchen Xin et al.
Ping Lin et al.
Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse family of polycyclic polyphenols. Some of them are consequently suggested as lead structures for drug development. Among them, rubrom...
The type IX secretion system: Insights into its function and connection to glycosylation in Cytophaga hutchinsonii [0.03%]
IX型分泌系统：其功能及与Cytophaga hutchinsonii糖基化作用关系的研究进展
Wenxia Song,Xueke Zhuang,Yahong Tan et al.
Wenxia Song et al.
The recently discovered type IX secretion system (T9SS) is limited to the Bacteroidetes phylum. Cytophaga hutchinsonii, a member of the Bacteroidetes phylum widely spread in soil, has complete orthologs of T9SS components and many T9SS subs...
Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate [0.03%]
由六异戊二烯焦磷酸衍生的新一类三萜的发现及分析
Dan Hu
Dan Hu
Triterpenes are derived from squalene or oxidosqualene. However, a new class of triterpenes derived from hexaprenyl pyrophosphate has been recently discovered, formed by a new family of chimeric class I triterpene synthases. The cyclization...
Copper-radical oxidases: A diverse group of biocatalysts with distinct properties and a broad range of biotechnological applications [0.03%]
铜类酶：一类具有特殊性质和广泛生物技术应用前景的生物催化剂
Katja Koschorreck,Saadet Alpdagtas,Vlada B Urlacher
Katja Koschorreck
Copper-radical oxidases (CROs) catalyze the two-electron oxidation of a large number of primary alcohols including carbohydrates, polyols and benzylic alcohols as well as aldehydes and α-hydroxy-carbonyl compounds while reducing molecular ...
Yamei Gan,Xin Meng,Cong Gao et al.
Yamei Gan et al.
The increasing shortage of fossil resources and environmental pollution has renewed interest in the synthesis of value-added biochemicals from methanol. However, most of native or synthetic methylotrophs are unable to assimilate methanol at...