Recent developments in the identification and biosynthesis of antitumor drugs derived from microorganisms [0.03%]
近年来微生物来源抗肿瘤药物的研究进展及生物合成路径探究
Qi Gao,Sizhe Deng,Tianyu Jiang
Qi Gao
Secondary metabolites in microorganisms represent a resource for drug discovery and development. In particular, microbial-derived antitumor agents are in clinical use worldwide. Herein, we provide an overview of the development of classical...
Dake Liu,Nicole E Siguenza,Amir Zarrinpar et al.
Dake Liu et al.
The microbiome is an essential component of ecological systems and is comprised of a diverse array of microbes. Over the past decades, the accumulated observational evidence reveals a close correlation between the microbiome and human healt...
Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals [0.03%]
乙酸作为化工生产代谢工程的构建模块有广阔前景
Guiping Gong,Bo Wu,Linpei Liu et al.
Guiping Gong et al.
The production of biofuels and biochemicals derived from microbial fermentation has received a lot of attention and interest in light of concerns about the depletion of fossil fuel resources and climatic degeneration. However, the economic ...
Aquaculture sustainability through alternative dietary ingredients: Microalgal value-added products [0.03%]
微藻高价值产品在水产养殖可持续性中的作用：替代饲料原料
John N Idenyi,Jonathan C Eya,Amechi S Nwankwegu et al.
John N Idenyi et al.
Aquaculture contributes remarkably to the global economy and food security through seafood production, an important part of the global food supply chain. The success of this industry depends heavily on aquafeeds, and the nutritional composi...
Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase [0.03%]
丝氨酸乙酰化降低大肠杆菌乳酸脱氢酶的活性和蛋白水平
Min Liu,Meitong Huo,Likun Guo et al.
Min Liu et al.
Lactate is an important bulk chemical with widespread applications and a major byproduct of other chemicals bioprocess in microbial fermentation. Lactate dehydrogenase A (LdhA) catalyzes the synthesis of lactate from pyruvate. Lysine acetyl...
Cascade-Cas3 facilitates high-accuracy genome engineering in Pseudomona s using phage-encoded homologous recombination [0.03%]
利用噬菌体编码同源重组在假单胞门中进行高精度基因组编辑的Cascade-Cas3作用机制研究
Wentao Zheng,Yandong Xia,Xue Wang et al.
Wentao Zheng et al.
Phage-encoded homologous recombination (PEHR) is an efficient tool for bacterial genome editing. We previously developed and utilized a Pseudomonas-specific PEHR system. However, when using the PEHR system for Pseudomonas genome editing, fa...
Jianping Huang,Shengxiong Huang
Jianping Huang
The de novo biosynthesis of vindoline and catharanthine, the direct precursors used for industrial production of the anti-cancer drug vinblastine, has been achieved in the yeast cell factory. To date, this is the longest natural product bio...
A chemoenzymatic cascade with the potential to feed the world and allow humans to live in space [0.03%]
一种有潜力解决世界粮食问题并允许人类在太空生活的方法
Shuke Wu,Uwe T Bornscheuer
Shuke Wu
While the typical targets of (chemo-)enzymatic cascades are fine chemicals (e.g., pharmaceuticals), a chemoenzymatic cascade, artificial starch anabolic pathway (ASAP), was recently developed to synthesize starch from CO2. The key results a...
In vitro characterization of a nitro-forming oxygenase involved in 3-(trans-2'-aminocyclopropyl)alanine biosynthesis [0.03%]
参与3-(反式-2'-氨基环丙基)甘氨酸生物合成的硝基形成氧合酶的体外表征
Linlin Pang,Weijing Niu,Yuwei Duan et al.
Linlin Pang et al.
In vitro characterization experiments revealed the formations of 3-(trans-2'-aminocyclopropyl)alanine ((3-Acp)Ala) and 3-(trans-2'-nitrocyclopropyl)alanine ((3-Ncp)Ala) are originated via two homologous proteins, BelK and HrmI, which regios...
Shengling Xie,Lihan Zhang
Shengling Xie
The redox cofactor β-nicotinamide adenine dinucleotide (NAD) has been revealed to serve as a building block for the biosynthesis of an alkaloid natural product, altemicidin. The biosynthetic pathway investigation identified a unique pyrido...