Xenopus tropicalis osteoblast-specific open chromatin regions reveal promoters and enhancers involved in human skeletal phenotypes and shed light on early vertebrate evolution [0.03%]
Xenopus tropicalis成骨细胞特异性开放染色质区域揭示参与人类骨骼表型的启动子和增强子并阐明早期脊椎动物进化问题
Héctor Castillo,Patricia Hanna,Laurent M Sachs et al.
Héctor Castillo et al.
While understanding the genetic underpinnings of osteogenesis has far-reaching implications for skeletal diseases and evolution, a comprehensive characterization of the osteoblastic regulatory landscape in non-mammalian vertebrates is still...
Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis [0.03%]
鸟类皮肤发育过程中的血管网络适应性图案化：间充质可塑性和真皮血管发生
Kuang-Ling Ou,Chih-Kuan Chen,Junxiang J Huang et al.
Kuang-Ling Ou et al.
A vasculature network supplies blood to feather buds in the developing skin. Does the vasculature network during early skin development form by sequential sprouting from the central vasculature or does local vasculogenesis occur first that ...
Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices [0.03%]
肾脏细胞来源基质中的IV型胶原装配受流体流动影响
Pinyuan Tian,Nikki-Maria Koudis,Mychel R P T Morais et al.
Pinyuan Tian et al.
Kidney podocytes and endothelial cells assemble a complex and dynamic basement membrane that is essential for kidney filtration. Whilst many components of this specialised matrix are known, the influence of fluid flow on its assembly and or...
Celebrating the centennial of the most famous experiment in embryology: Hilde Mangold, Hans Spemann and the organizer [0.03%]
庆祝胚胎学最著名的实验百年纪念：希尔德·芒戈尔德、汉斯·斯佩曼与组织者效应
Edward M De Robertis,Wolfgang Driever,Roberto Mayor
Edward M De Robertis
This Issue of Cells & Development celebrates the centennial of the Spemann-Mangold organizer experiment. This was the most famous experiment in embryology and its reverberations have greatly influenced developmental biology. This historical...
Brain enlargement with rostral bias in larvae from a spontaneously occurring female variant line of Xenopus; role of aberrant embryonic Wnt/β-catenin signaling [0.03%]
非洲爪蟾雌性突变体品系自发产生的幼体脑增大现象及其胚胎Wnt/β-连环蛋白信号异常的作用机制
Ikuko Hongo,Chihiro Yamaguchi,Harumasa Okamoto
Ikuko Hongo
Increased brain size and its rostral bias are hallmarks of vertebrate evolution, but the underlying developmental and genetic basis remains poorly understood. To provide clues to understanding vertebrate brain evolution, we investigated the...
"And it was the worst possible result, because it actually worked:" An interview with Richard Harland [0.03%]
“而这却是最糟糕的结果，因为这个实际上起作用了”对Richard Harland的访谈
Richard M Harland,John B Wallingford
Richard M Harland
One hundred years ago, Hilde Mangold and Hans Spemann published their seminal paper on what came to be known as The Organizer, but seven decades would pass before the molecular basis of this remarkable phenomenon was revealed. Richard Harla...
Hilde Mangold: Original microscope slides and records of the gastrula organizer experiments [0.03%]
希尔德·芒格尔：原肠组织者实验的原始显微切片和记录
Wolfgang Driever,Jochen Holzschuh,Luise Sommer et al.
Wolfgang Driever et al.
The discovery of the amphibian gastrula organizer and its publication by Hans Spemann and Hilde Mangold in 1924 is a foundation of experimental embryology, and has shaped our understanding of embryonic induction and pattern formation in ver...
The significance of Ethel Browne's research on Hydra for the organizer concept [0.03%]
Ethel Browne对水螅的研究对于组织者概念的意义
Thomas W Holstein
Thomas W Holstein
This article focuses on the roots of the organizer concept, which was developed by Hans Spemann during his studies of early embryonic development in amphibians. The fundamental properties of this axis-inducing signaling center have been elu...
Qinghai Zhang,Pei Zhang,Min Yang et al.
Qinghai Zhang et al.
The Notch signaling pathway, an evolutionarily highly conserved pathway, participates in various essential physiological processes in organisms. Activation of Notch signaling in the canonical manner requires the combination of ligand and re...