Epigenetic signatures of trophoblast lineage and their biological functions [0.03%]
滋养层细胞谱系的表观遗传特征及其生物学功能
Jianqi Wang,Xiaobo Zhou,Tingli Han et al.
Jianqi Wang et al.
Trophoblasts play a crucial role in embryo implantation and in interacting with the maternal uterus. The trophoblast lineage develops into a substantial part of the placenta, a temporary extra-embryonic organ, capable of undergoing distinct...
The pluripotency state of human embryonic stem cells derived from single blastomeres of eight-cell embryos [0.03%]
由八细胞胚胎单个卵裂球衍生的人胚胎干细胞的多能性状态
Ot Massafret,Montserrat Barragán,Lucía Álvarez-González et al.
Ot Massafret et al.
Human embryonic stem cells (hESCs) derived from blastocyst stage embryos present a primed state of pluripotency, whereas mouse ESCs (mESCs) display naïve pluripotency. Their unique characteristics make naïve hESCs more suitable for partic...
The Oct4-related PouV gene, pou5f3, mediates isthmus development in zebrafish by directly and dynamically regulating pax2a [0.03%]
皮瓣发育相关的新 PouV 基因 pax2a 的直接动态调节因子
Masato Maekawa,Shinji Saito,Daiki Isobe et al.
Masato Maekawa et al.
Using a transgenic zebrafish line harboring a heat-inducible dominant-interference pou5f3 gene (en-pou5f3), we reported that this PouV gene is involved in isthmus development at the midbrain-hindbrain boundary (MHB), which patterns the midb...
A double-negative feedback loop mediated by non-coding RNAs contributes to tooth morphogenesis [0.03%]
由非编码RNA介导的双重负反馈环有助于牙齿形态发生
Meng Sun,Na Li,Weixing Zhang et al.
Meng Sun et al.
Tooth morphogenesis is a critically ordered process manipulated by a range of signaling factors. Particularly, the involvement of fine-tuned signaling mediated by non-coding RNAs has been of longstanding interest. Here, we revealed a double...
Marina Moro-López,Ramon Farré,Jorge Otero et al.
Marina Moro-López et al.
Cells isolated from their native tissues and cultured in vitro face different selection pressures than those cultured in vivo. These pressures induce a profound transformation that reshapes the cell, alters its genome, and transforms the wa...
Characterization of agouti-signaling protein (ASIP) in the bovine ovary and throughout early embryogenesis [0.03%]
反舌鸟信号蛋白（ASIP）在牛卵巢和胚胎早期发生过程中的特性分析
Heather L Chaney,Jaelyn Z Current,Mingxiang Zhang et al.
Heather L Chaney et al.
The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, or oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy followin...
Adela Kratochvilova,Lucia Knopfova,Janka Gregorkova et al.
Adela Kratochvilova et al.
Fas ligand (FasL, CD178) belongs to classical apoptotic molecules, however, recent evidence expands the spectrum of FasL functions into non-apoptotic processes which also applies for the bone. Tgfb subfamily members (Tgfb1, Tgfb2, Tgfb3) re...
AZIN2 is associated with apoptosis of germ cells in undescended testis [0.03%]
AZIN2与睾丸未降导致的生精细胞凋亡相关
Yuanyuan Gao,Shumin Xu,Jiajun Qiao et al.
Yuanyuan Gao et al.
Undescended testis (UDT), known as cryptorchidism (CRY), is a common congenital disorder in which one or both testicles do not descend normally into the scrotum. A unilateral UDT model was established by inducing UDT in mice through surgery...
Epigenetic inheritance of acquired traits via stem cells dedifferentiation/differentiation or transdifferentiation cycles [0.03%]
通过干细胞去分化/再分化或转分化的周期获得性状的表观遗传学传递
Arshak R Alexanian
Arshak R Alexanian
Inheritance of acquired characteristics is the once widely accepted idea that multiple modifications acquired by an organism during its life, can be inherited by the offspring. This belief is at least as old as Hippocrates and became popula...
Ex vivo organotypic bone slice culture reveals preferential chondrogenesis after sustained growth plate injury [0.03%]
持续生长板损伤后的类器官型骨切片培养显示软骨生成优先发生
Vanessa Etschmaier,Muammer Üçal,Birgit Lohberger et al.
Vanessa Etschmaier et al.
Postnatal bone growth primarily relies on chondrocyte proliferation and osteogenic differentiation within the growth plate (GP) via endochondral ossification. Despite its importance, the GP is vulnerable to injuries, affecting 15-30 % of bo...