Specialized structure and function of the apical extracellular matrix at sense organs [0.03%]
感觉器官顶侧细胞外基质的结构和功能的专门化
Wendy Fung,Irina Kolotuev,Maxwell G Heiman
Wendy Fung
Apical extracellular matrix (aECM) covers every surface of the body and exhibits tissue-specific structures that carry out specialized functions. This is particularly striking at sense organs, where aECM forms the interface between sensory ...
Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis [0.03%]
与特发性肺纤维化相关的纤连蛋白结合蛋白标志物的鉴定
Yu Sun,Benjamin King,Aaron J Hamlin et al.
Yu Sun et al.
The extracellular matrix (ECM) is a critical component of tissue where it provides structural and signaling support to cells. Its dysregulation and accumulation lead to fibrosis, a major clinical challenge underlying many diseases that curr...
Shuyao Kong,Mingyuan Zhu,Adrienne H K Roeder
Shuyao Kong
Development is a self-organized process that builds on cells and their interactions. Cells are heterogeneous in gene expression, growth, and division; yet how development is robust despite such heterogeneity is a fascinating question. Here,...
Epigenetic signatures of trophoblast lineage and their biological functions [0.03%]
滋养层细胞谱系的表观遗传特征及其生物学功能
Jianqi Wang,Xiaobo Zhou,Tingli Han et al.
Jianqi Wang et al.
Trophoblasts play a crucial role in embryo implantation and in interacting with the maternal uterus. The trophoblast lineage develops into a substantial part of the placenta, a temporary extra-embryonic organ, capable of undergoing distinct...
The pluripotency state of human embryonic stem cells derived from single blastomeres of eight-cell embryos [0.03%]
由八细胞胚胎单个卵裂球衍生的人胚胎干细胞的多能性状态
Ot Massafret,Montserrat Barragán,Lucía Álvarez-González et al.
Ot Massafret et al.
Human embryonic stem cells (hESCs) derived from blastocyst stage embryos present a primed state of pluripotency, whereas mouse ESCs (mESCs) display naïve pluripotency. Their unique characteristics make naïve hESCs more suitable for partic...
The Oct4-related PouV gene, pou5f3, mediates isthmus development in zebrafish by directly and dynamically regulating pax2a [0.03%]
皮瓣发育相关的新 PouV 基因 pax2a 的直接动态调节因子
Masato Maekawa,Shinji Saito,Daiki Isobe et al.
Masato Maekawa et al.
Using a transgenic zebrafish line harboring a heat-inducible dominant-interference pou5f3 gene (en-pou5f3), we reported that this PouV gene is involved in isthmus development at the midbrain-hindbrain boundary (MHB), which patterns the midb...
A double-negative feedback loop mediated by non-coding RNAs contributes to tooth morphogenesis [0.03%]
由非编码RNA介导的双重负反馈环有助于牙齿形态发生
Meng Sun,Na Li,Weixing Zhang et al.
Meng Sun et al.
Tooth morphogenesis is a critically ordered process manipulated by a range of signaling factors. Particularly, the involvement of fine-tuned signaling mediated by non-coding RNAs has been of longstanding interest. Here, we revealed a double...
Marina Moro-López,Ramon Farré,Jorge Otero et al.
Marina Moro-López et al.
Cells isolated from their native tissues and cultured in vitro face different selection pressures than those cultured in vivo. These pressures induce a profound transformation that reshapes the cell, alters its genome, and transforms the wa...
Characterization of agouti-signaling protein (ASIP) in the bovine ovary and throughout early embryogenesis [0.03%]
反舌鸟信号蛋白（ASIP）在牛卵巢和胚胎早期发生过程中的特性分析
Heather L Chaney,Jaelyn Z Current,Mingxiang Zhang et al.
Heather L Chaney et al.
The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, or oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy followin...
Adela Kratochvilova,Lucia Knopfova,Janka Gregorkova et al.
Adela Kratochvilova et al.
Fas ligand (FasL, CD178) belongs to classical apoptotic molecules, however, recent evidence expands the spectrum of FasL functions into non-apoptotic processes which also applies for the bone. Tgfb subfamily members (Tgfb1, Tgfb2, Tgfb3) re...