Estetrol potentiates progesterone-driven growth restraint while blunting pro-angiogenic activation in murine endometriosis lesions [0.03%]
雌激素类似物estetrol通过增强孕酮的抗增殖作用同时抑制促血管生成活化来改善小鼠子宫内膜异位病灶
Gabriel Maldonado,Cristian Espinoza,Anna Arias et al.
Gabriel Maldonado et al.
Background: Endometriosis is sustained by ectopic endometrial implants that remain proliferative and vascularized, making endocrine modulation a cornerstone of therapy. Estetrol (E4) an endogenous estrogen produced during...
Transcriptomic signatures and neural cell composition in schizophrenia iPSC-derived neuron cultures [0.03%]
精神分裂症诱导多能干细胞来源神经细胞系的转录组标志和神经元组成
Bárbara S Casas,Jorge Zúñiga,Sebastián Arizábalos et al.
Bárbara S Casas et al.
Schizophrenia is a neurodevelopmental disorder associated with alterations in neuronal function and connectivity. It has been extensively modeled using neurons derived from induced pluripotent stem cells (iPSC), where significant difference...
Upregulation of adenylyl cyclase 1 is crucial for osteogenic and adipogenic differentiation of MSCs [0.03%]
腺苷酸环化酶1的上调对间充质干细胞成骨和成脂分化至关重要
Vladimir Usachev,Nikita Voloshin,Alexandra Primak et al.
Vladimir Usachev et al.
Introduction: Adenylyl cyclase (AC) is an important enzyme that mediates stem cells' response to hormonal stimuli. Despite the fact that currently there are ten described isoforms of AC little is known about their individ...
Fabian Gärtner,Lale Alpar,Yohanns Bellaïche
Fabian Gärtner
Toll-like receptors (TLRs) were first identified as developmental cues that establish the dorsal-ventral axis in Drosophila. This discovery was followed by the recognition of their central role in invertebrate and vertebrate innate immunity...
Lily Acker,Hui Chen
Lily Acker
Breast Cancer Gene 1 (BRCA1) is a critical regulator of genome integrity whose dysfunction greatly increases lifetime risk of breast and ovarian cancers. While BRCA1 has been extensively studied in the contexts of adult biology and cancer, ...
The face you're born with: How early development dictates a lifetime of expression and ageing [0.03%]
与生俱来的那张脸：早期发育决定了一生的表情和衰老过程
Eqram Rahman,Parinitha Rao,Golam Saklayen et al.
Eqram Rahman et al.
Facial ageing manifests in highly consistent, topologically predictable patterns, including nasolabial folds and tear troughs, despite wide inter-individual variation in anatomy and soft-tissue volume loss. Current clinical models emphasise...
Inhibition of circNUP93 (hsa_circ_0039480) activates the IRS-1/Akt pathway and alleviates insulin resistance in gestational diabetes mellitus via the MiR-767-3p/HIF1A axis [0.03%]
circNUP93（hsa_circ_0039480）通过MiR-767-3p/HIF1A轴抑制激活IRS-1/Akt通路并缓解妊娠期糖尿病患者的胰岛素抵抗
Xiao Chen,Hong Yang,Anna Zhao et al.
Xiao Chen et al.
Gestational diabetes mellitus (GDM) is characterized by insulin resistance (IR) and impaired glucose tolerance during pregnancy, yet the upstream regulatory mechanisms controlling insulin signaling remain unclear. The circular RNA hsa_circ_...
A comparative study of deep learning-based zebrafish image segmentation methods [0.03%]
基于深度学习的斑马鱼图像分割方法的比较研究
Yuan Chen,Jian Chen,Yachen Jiang et al.
Yuan Chen et al.
This study systematically evaluates several deep learning-based segmentation networks for zebrafish image analysis. With the same dataset and preprocessing procedures, we selected eleven representative segmentation models, including U-Net, ...
ankrd1a is consistently upregulated in cardiomyocytes bordering the injury or scar area and affects their dedifferentiation during zebrafish heart regeneration [0.03%]
ANKRD1A在临近损伤或瘢痕区域的心肌细胞中持续高表达并影响斑马鱼心脏再生过程中心肌细胞的去分化
Srdjan Boskovic,Mirjana Novkovic,Andjela Milicevic et al.
Srdjan Boskovic et al.
In contrast to humans, zebrafish have an outstanding ability to regenerate injured heart through a highly orchestrated process involving all cardiac structures. To replace the lost myocardium, resident cardiomyocytes (CMs) dedifferentiate a...
ZebRack: A budget-friendly mobile system for short-term zebrafish housing [0.03%]
ZebRack：一种短期饲养斑马鱼的低成本移动系统
Pauline Sallaberry-Pincheira,Aarón Villanueva,Leonardo E Valdivia
Pauline Sallaberry-Pincheira
The zebrafish (Danio rerio) has become a popular model organism in developmental biology, but the high costs of commercial housing systems often limit accessibility for resource-constrained research and educational purposes. Here, we introd...