Emerging therapeutic strategies for Wnt-dependent colon cancer targeting macropinocytosis [0.03%]
针对巨胞饮作用的Wnt依赖性结直肠癌新兴治疗策略
Nydia Tejeda-Muñoz,Grace Binder,Kuo-Ching Mei
Nydia Tejeda-Muñoz
Aberrations in the Wnt signaling pathway, particularly mutations in genes like APC and β-catenin, are pivotal in initiating and driving the progression of colorectal cancer (CRC), establishing this pathway as a crucial target for therapeut...
The evolutionary and mechanical principles shaping the Drosophila embryonic ventral nerve cord [0.03%]
塑造果蝇胚胎腹神经索的进化和机械原理
Katerina Karkali,Enrique Martín-Blanco
Katerina Karkali
The establishment of communication circuits requires bringing sources and targets into contact, either directly or indirectly. The Central Nervous System (CNS)'s ability to interpret the environment and generate precise responses depends on...
Dissecting the mystery of embryonic scaling: The Scalers Hypothesis and its confirmation in sea urchin embryos [0.03%]
破解胚胎尺度变化之谜：“缩放器”假说及海胆胚胎中的验证
Polina S Timoshina,Alexey M Nesterenko,Elena A Parshina et al.
Polina S Timoshina et al.
Embryonic scaling, the ability of embryos to regulate their spatial structure in proportion to size, remains a fascinating yet poorly studied problem in developmental biology. First described in sea urchin embryos by Hans Driesch, this phen...
D Weiss,N Yeung,A B Ramachandra et al.
D Weiss et al.
The aorta exhibits tremendous changes in geometry, composition, and mechanical properties during postnatal development. These changes are necessarily driven by transcriptional changes, both genetically programmed and mechano-responsive, but...
Establishment of functional trophoblast organoids from trophoblast cells of bovine placenta [0.03%]
牛胎盘滋养细胞的功能性滋养层类器官的建立
Bingying Liu,Siqi Ren,Hong An et al.
Bingying Liu et al.
The placenta is an organ that plays a vital role in successful pregnancies, and the failure of early placentation is a significant factor leading to abortion in ruminant species. However, the mechanisms involved in the development and diffe...
Twisted cell flow facilitates three-dimensional somite morphogenesis in zebrafish [0.03%]
扭曲的细胞流促进了斑马鱼三维节片形态的发生
Harunobu Kametani,Yue Tong,Atsuko Shimada et al.
Harunobu Kametani et al.
Tissue elongation is a fundamental morphogenetic process to construct complex embryonic structures. In zebrafish, somites rapidly elongate in both dorsal and ventral directions, transforming from a cuboidal to a V-shape within a few hours o...
Of criminals and cancer: The importance of social bonds and innate morality on cellular societies [0.03%]
罪犯与癌症——社会纽带和内在道德观在细胞社会中的重要性
Anuraag Bukkuri,Frederick R Adler
Anuraag Bukkuri
The current dogma in cancer biology contends that cancer is an identity problem: mutations in a cell's DNA cause it to "go rogue" and proliferate out of control. However, this largely ignores the role of cell-cell interaction and fails to e...
'Three signals - three body axes' as patterning principle in bilaterians [0.03%]
“三信号-三轴”理论作为双边动物模式形成的基本原则
Christof Niehrs,Ettore Zapparoli,Hyeyoon Lee
Christof Niehrs
In vertebrates, the three orthogonal body axes, anteroposterior (AP), dorsoventral (DV) and left-right (LR) are determined at gastrula and neurula stages by the Spemann-Mangold organizer and its equivalents. A common feature of AP and DV ax...
Podoplanin and its multifaceted roles in mammalian developmental program [0.03%]
Podoplanin及其在哺乳动物发育程序中的多种作用
Yi Ying Cheok,Grace Min Yi Tan,Yee Teng Chan et al.
Yi Ying Cheok et al.
Podoplanin is a vital molecule which plays an integral part in the regulation of development, immunity, and cancer. Expression of Podoplanin is detected at different early developmental stages of mammalian embryo, and it functions to modula...
Induction of Embryonic Primordia by Implantation of Organizers from a Different Species [0.03%]
异种组织者植入诱导原肠胚形成
Hans Spemann,Hilde Mangold Née Pröscholdt
Hans Spemann