Twisted cell flow facilitates three-dimensional somite morphogenesis in zebrafish [0.03%]
扭曲的细胞流促进了斑马鱼三维节片形态的发生
Harunobu Kametani,Yue Tong,Atsuko Shimada et al.
Harunobu Kametani et al.
Tissue elongation is a fundamental morphogenetic process to construct complex embryonic structures. In zebrafish, somites rapidly elongate in both dorsal and ventral directions, transforming from a cuboidal to a V-shape within a few hours o...
Of criminals and cancer: The importance of social bonds and innate morality on cellular societies [0.03%]
罪犯与癌症——社会纽带和内在道德观在细胞社会中的重要性
Anuraag Bukkuri,Frederick R Adler
Anuraag Bukkuri
The current dogma in cancer biology contends that cancer is an identity problem: mutations in a cell's DNA cause it to "go rogue" and proliferate out of control. However, this largely ignores the role of cell-cell interaction and fails to e...
'Three signals - three body axes' as patterning principle in bilaterians [0.03%]
“三信号-三轴”理论作为双边动物模式形成的基本原则
Christof Niehrs,Ettore Zapparoli,Hyeyoon Lee
Christof Niehrs
In vertebrates, the three orthogonal body axes, anteroposterior (AP), dorsoventral (DV) and left-right (LR) are determined at gastrula and neurula stages by the Spemann-Mangold organizer and its equivalents. A common feature of AP and DV ax...
Podoplanin and its multifaceted roles in mammalian developmental program [0.03%]
Podoplanin及其在哺乳动物发育程序中的多种作用
Yi Ying Cheok,Grace Min Yi Tan,Yee Teng Chan et al.
Yi Ying Cheok et al.
Podoplanin is a vital molecule which plays an integral part in the regulation of development, immunity, and cancer. Expression of Podoplanin is detected at different early developmental stages of mammalian embryo, and it functions to modula...
Induction of Embryonic Primordia by Implantation of Organizers from a Different Species [0.03%]
异种组织者植入诱导原肠胚形成
Hans Spemann,Hilde Mangold Née Pröscholdt
Hans Spemann
Specialized structure and function of the apical extracellular matrix at sense organs [0.03%]
感觉器官顶侧细胞外基质的结构和功能的专门化
Wendy Fung,Irina Kolotuev,Maxwell G Heiman
Wendy Fung
Apical extracellular matrix (aECM) covers every surface of the body and exhibits tissue-specific structures that carry out specialized functions. This is particularly striking at sense organs, where aECM forms the interface between sensory ...
Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis [0.03%]
与特发性肺纤维化相关的纤连蛋白结合蛋白标志物的鉴定
Yu Sun,Benjamin King,Aaron J Hamlin et al.
Yu Sun et al.
The extracellular matrix (ECM) is a critical component of tissue where it provides structural and signaling support to cells. Its dysregulation and accumulation lead to fibrosis, a major clinical challenge underlying many diseases that curr...
Shuyao Kong,Mingyuan Zhu,Adrienne H K Roeder
Shuyao Kong
Development is a self-organized process that builds on cells and their interactions. Cells are heterogeneous in gene expression, growth, and division; yet how development is robust despite such heterogeneity is a fascinating question. Here,...
Epigenetic signatures of trophoblast lineage and their biological functions [0.03%]
滋养层细胞谱系的表观遗传特征及其生物学功能
Jianqi Wang,Xiaobo Zhou,Tingli Han et al.
Jianqi Wang et al.
Trophoblasts play a crucial role in embryo implantation and in interacting with the maternal uterus. The trophoblast lineage develops into a substantial part of the placenta, a temporary extra-embryonic organ, capable of undergoing distinct...
The pluripotency state of human embryonic stem cells derived from single blastomeres of eight-cell embryos [0.03%]
由八细胞胚胎单个卵裂球衍生的人胚胎干细胞的多能性状态
Ot Massafret,Montserrat Barragán,Lucía Álvarez-González et al.
Ot Massafret et al.
Human embryonic stem cells (hESCs) derived from blastocyst stage embryos present a primed state of pluripotency, whereas mouse ESCs (mESCs) display naïve pluripotency. Their unique characteristics make naïve hESCs more suitable for partic...