The evolutionary origin and mechanism of chordate tail regeneration. An ancient tale? [0.03%]
脊索动物尾再生的进化起源与机制。古老的故事？
Wouter Masselink,Prayag Murawala
Wouter Masselink
Chordate tail regeneration represents the remarkable ability of some chordates to partially or completely regenerate a significant portion of their primary body axis. In this review we will discuss the chordate regenerative ability, what is...
Homeotic transformation of tail to limbs: A novel morphogenesis in the framework of self-organization and reprogramming of cell fate during appendage regeneration [0.03%]
尾变四肢：附肢再生过程中细胞命运的自我组织和重编程框架内的新型形态发生现象
Jutshina Hota,Swetamudra Pattnaik,Gunanidhi Sahoo et al.
Jutshina Hota et al.
Homeotic transformation of tail to hindlimbs in anuran tadpoles is a manifestation of the reprogramming of positional information in the event of tail regeneration. Such discovery of homeosis is of particular interest considering its occurr...
Tissue mechanics modulate morphogen signalling to induce the head organiser [0.03%]
组织力学调制形态发生素信号以诱导头部组织者形成
Matyas Bubna-Litic,Guillaume Charras,Roberto Mayor
Matyas Bubna-Litic
Morphogenetic movements and specification of germ layers during gastrulation are key processes that establish the vertebrate body plan. Despite substantial research into the role of tissue mechanics during gastrulation and detailed characte...
LUC7L2 accelerates the growth of liver cancer cells by enhancing DNA damage repair via RRAS [0.03%]
LUC7L2通过RRAS增强DNA损伤修复以促进肝癌细胞增殖
Xinlei Liu,Sijie Xie,Xiaoxue Jiang et al.
Xinlei Liu et al.
Background & objectives: LUC7L2 may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. However, their detailed features and regulatory mechanisms of L...
Hyung Kyu Choi,Sung-Hwan Moon
Hyung Kyu Choi
Research on early human development is crucial for understanding the origins of life and mechanisms underlying disease onset. However, these studies have significant challenges owing to ethical restrictions and technical limitations. Stem c...
Emerging therapeutic strategies for Wnt-dependent colon cancer targeting macropinocytosis [0.03%]
针对巨胞饮作用的Wnt依赖性结直肠癌新兴治疗策略
Nydia Tejeda-Muñoz,Grace Binder,Kuo-Ching Mei
Nydia Tejeda-Muñoz
Aberrations in the Wnt signaling pathway, particularly mutations in genes like APC and β-catenin, are pivotal in initiating and driving the progression of colorectal cancer (CRC), establishing this pathway as a crucial target for therapeut...
The evolutionary and mechanical principles shaping the Drosophila embryonic ventral nerve cord [0.03%]
塑造果蝇胚胎腹神经索的进化和机械原理
Katerina Karkali,Enrique Martín-Blanco
Katerina Karkali
The establishment of communication circuits requires bringing sources and targets into contact, either directly or indirectly. The Central Nervous System (CNS)'s ability to interpret the environment and generate precise responses depends on...
Dissecting the mystery of embryonic scaling: The Scalers Hypothesis and its confirmation in sea urchin embryos [0.03%]
破解胚胎尺度变化之谜：“缩放器”假说及海胆胚胎中的验证
Polina S Timoshina,Alexey M Nesterenko,Elena A Parshina et al.
Polina S Timoshina et al.
Embryonic scaling, the ability of embryos to regulate their spatial structure in proportion to size, remains a fascinating yet poorly studied problem in developmental biology. First described in sea urchin embryos by Hans Driesch, this phen...
D Weiss,N Yeung,A B Ramachandra et al.
D Weiss et al.
The aorta exhibits tremendous changes in geometry, composition, and mechanical properties during postnatal development. These changes are necessarily driven by transcriptional changes, both genetically programmed and mechano-responsive, but...
Establishment of functional trophoblast organoids from trophoblast cells of bovine placenta [0.03%]
牛胎盘滋养细胞的功能性滋养层类器官的建立
Bingying Liu,Siqi Ren,Hong An et al.
Bingying Liu et al.
The placenta is an organ that plays a vital role in successful pregnancies, and the failure of early placentation is a significant factor leading to abortion in ruminant species. However, the mechanisms involved in the development and diffe...