Jing Chen,Anming Meng
Jing Chen
The establishment of the body axis and developmental blueprint in embryos has remained to be a central question in developmental biology, captivating scientists for centuries. A milestone in this field was achieved in 1924 when Hans Spemann...
Mucociliary cell type compositions - bridging the gap between genes and emergent tissue functions [0.03%]
黏液纤毛细胞类型的组成--在基因与组织功能之间建立联系
Peter Walentek
Peter Walentek
When multiple cell types are brought together to form a tissue-specific collective, the combination of cell functions and cell-cell interactions leads to novel behaviors and properties beyond the simple addition of individual features, ofte...
Cell biology of the chick organizer: Origins, composition, population dynamics and fate [0.03%]
鸡组织者的细胞生物学：起源、构成、种群动力学和命运
Claudio D Stern
Claudio D Stern
The year 2024 celebrates 100 years of perhaps one of the most important and influential papers in the field of developmental biology, Spemann and Mangold's publication reporting the discovery of the "organizer", which can induce and pattern...
Xin Chen,Run Yang,Tianyu Zhang et al.
Xin Chen et al.
Recent studies have identified pathogenic variants in the FOXI3 gene associated with craniofacial microsomia pedigrees. In zebrafish, the foxi1 gene is considered a functional homolog of the mouse Foxi3. However, research on foxi3a and foxi...
Dorsoventral patterning beyond the gastrulation stage: Interpretation of early dorsoventral cues and modular development mediated by zic1/zic4 [0.03%]
背腹模式形成超过囊胚阶段：早期背腹提示的解读及zic1/zic4介导的模块化发育
Toru Kawanishi,Hiroyuki Takeda
Toru Kawanishi
Dorsoventral (DV) patterning is fundamental to vertebrate development, organizing the entire body across different germ layers. Although early DV axis formation, centered on the Spemann-Mangold organizer through the BMP activity gradient, h...
Nuclear localization and transactivation of SYS-1/β-catenin is the result of serial gene duplications and subfunctionalizations [0.03%]
SYS-1/β-连环蛋白的核定位及转激活是连续基因重复和亚功能分化的结果
Arielle K Wolf,Lori C Adams-Phillips,Amanda N D Adams et al.
Arielle K Wolf et al.
β-catenin is a highly conserved multifunctional protein capable of mediating cell adhesion via E-cadherin and transactivation of target genes of the canonical Wnt signaling pathway. The nematode, C. elegans contains four paralogs of β-cat...
Raffee Wright,Valerie Wilson
Raffee Wright
The production of the vertebrate body axis involves the coordinating activity of the organizer, which coincides in amniotes with the node in the gastrulating embryo. This organizer orchestrates nearby axial progenitor populations that produ...
Equine adult, fetal and ESC-tenocytes have differential migratory, proliferative and gene expression responses to factors upregulated in the injured tendon [0.03%]
马成人、胎儿和多能干细胞来源的腱细胞对损伤肌腱中上调因子的迁移、增殖和基因表达反应不同
Ross E Beaumont,Emily J Smith,Clara David et al.
Ross E Beaumont et al.
Tendon injuries are a common problem in humans and horses. There is a high re-injury rate in both species due to the poor regeneration of adult tendon and the resulting formation of scar tissue. In contrast, fetal tendon injuries undergo sc...
Organizer formation, organizer maintenance and epithelial cell plasticity in Hydra: Role of the Wnt3/β-catenin/TCF/Sp5/Zic4 gene network [0.03%]
水母中组织者形成、维持及上皮细胞可塑性：Wnt3/β-catenin/TCF/Sp5/Zic4基因网络的作用
Brigitte Galliot,Yvan Wenger
Brigitte Galliot
The experimental and conceptual knowledge in 1909 led to the discovery of the Hydra head organizer through transplantation experiments between pigmented and non-pigmented animals; a discovery followed by numerous transplantations demonstrat...
Jenny Kretzschmar,Katharine Goodwin,Katie McDole
Jenny Kretzschmar
The discovery of the embryonic organizer by Hilde Mangold and Hans Spemann in 1924 was one of the most ground-breaking achievements in the 1900 century for developmental biologists and beyond. Ever since the organizer was first described in...