Lila Neahring,Jennifer A Zallen
Lila Neahring
Epithelia are ubiquitous tissues with essential structural, signaling, and barrier functions. How individual cells act collectively to assemble and remodel epithelia throughout development is a fundamental question in developmental biology....
Temporal regulation of endoderm convergence and extension by the BMP activity gradient through mesoderm-dependent and independent mechanisms [0.03%]
BMP活性梯度通过中胚层依赖和非依赖机制对内胚层聚合和延伸的时相调控
Chia-Teng Chang,Tony Tsai,Lila Solnica-Krezel
Chia-Teng Chang
One hundred years ago, Spemann and Mangold identified the organizer, a critical embryonic region that establishes vertebrate body axes by directing cell fate and morphogenesis. A conserved vertebrate mechanism involves the regulation of a v...
Transcending the hegemony of the molecular machine through an organic renewal of biology and biomedicine [0.03%]
通过生物学和生物医学的有机更新超越分子机器的霸权
Amy E Shyer,Alan R Rodrigues
Amy E Shyer
The dominant approach to the study of living systems in the 20th century into today has been that of a reductionist approach focused on genetics and biochemistry. The hunt for genes and the elucidation of their biochemical outputs has organ...
Jing Chen,Anming Meng
Jing Chen
The establishment of the body axis and developmental blueprint in embryos has remained to be a central question in developmental biology, captivating scientists for centuries. A milestone in this field was achieved in 1924 when Hans Spemann...
Mucociliary cell type compositions - bridging the gap between genes and emergent tissue functions [0.03%]
黏液纤毛细胞类型的组成--在基因与组织功能之间建立联系
Peter Walentek
Peter Walentek
When multiple cell types are brought together to form a tissue-specific collective, the combination of cell functions and cell-cell interactions leads to novel behaviors and properties beyond the simple addition of individual features, ofte...
Cell biology of the chick organizer: Origins, composition, population dynamics and fate [0.03%]
鸡组织者的细胞生物学：起源、构成、种群动力学和命运
Claudio D Stern
Claudio D Stern
The year 2024 celebrates 100 years of perhaps one of the most important and influential papers in the field of developmental biology, Spemann and Mangold's publication reporting the discovery of the "organizer", which can induce and pattern...
Xin Chen,Run Yang,Tianyu Zhang et al.
Xin Chen et al.
Recent studies have identified pathogenic variants in the FOXI3 gene associated with craniofacial microsomia pedigrees. In zebrafish, the foxi1 gene is considered a functional homolog of the mouse Foxi3. However, research on foxi3a and foxi...
Dorsoventral patterning beyond the gastrulation stage: Interpretation of early dorsoventral cues and modular development mediated by zic1/zic4 [0.03%]
背腹模式形成超过囊胚阶段：早期背腹提示的解读及zic1/zic4介导的模块化发育
Toru Kawanishi,Hiroyuki Takeda
Toru Kawanishi
Dorsoventral (DV) patterning is fundamental to vertebrate development, organizing the entire body across different germ layers. Although early DV axis formation, centered on the Spemann-Mangold organizer through the BMP activity gradient, h...
Nuclear localization and transactivation of SYS-1/β-catenin is the result of serial gene duplications and subfunctionalizations [0.03%]
SYS-1/β-连环蛋白的核定位及转激活是连续基因重复和亚功能分化的结果
Arielle K Wolf,Lori C Adams-Phillips,Amanda N D Adams et al.
Arielle K Wolf et al.
β-catenin is a highly conserved multifunctional protein capable of mediating cell adhesion via E-cadherin and transactivation of target genes of the canonical Wnt signaling pathway. The nematode, C. elegans contains four paralogs of β-cat...
Raffee Wright,Valerie Wilson
Raffee Wright
The production of the vertebrate body axis involves the coordinating activity of the organizer, which coincides in amniotes with the node in the gastrulating embryo. This organizer orchestrates nearby axial progenitor populations that produ...