The characterization of the biological effect of hypoxia-mimetic condition on angiogenic potential in mesenchymal stem cells derived from different origins [0.03%]
低氧诱导不同来源间充质干细胞血管生成潜能的表征研究
Yeo Gyun Yun,Donghyeon Yeo,Trang Thanh Thien Tran et al.
Yeo Gyun Yun et al.
Under physiological conditions, adult stem cells are located in a special microenvironment, known as the niche, which is characterized by low oxygen levels. Hypoxia is a crucial factor regulating stem cell behavior, and in vitro normoxic cu...
Zishuo Xu,Ansar Hussain,Hanwei Jiang et al.
Zishuo Xu et al.
A-kinase anchoring proteins (AKAPs) constitute a structurally diverse family of scaffold proteins with significant functional relevance. Various AKAP family members localize to distinct subcellular compartments, such as sperm flagella, via ...
A modular organization of mammalian gastrulation and the Spemann-Mangold organizer [0.03%]
哺乳动物原肠运动的模块化组织及其斯佩曼-孟加顿组织中心
Alfonso Martinez Arias,André Dias,Alexandra E Wehmeyer et al.
Alfonso Martinez Arias et al.
Studies in amphibian embryos revealed the existence of groups of cells, organizers, that play a central role in laying down the body plan. One, the Spemann-Mangold Organizer (SMO) is associated with the induction of the nervous system and t...
A comparative analysis of the chorioallantoic membrane as an experimental model to study angiogenesis and vascular development in the chick and quail embryos [0.03%]
鸡和鹌鹑胚胎中血发育研究的合体膜实验模型比较分析
Domenico Ribatti
Domenico Ribatti
The avian embryo is a model in which experimental embryology and cellular and molecular biology techniques can converge to address fundamental questions of development biology. Chick and quail have been powerful partners in the investigatio...
Towards an integrated view and understanding of embryonic signalling during murine gastrulation [0.03%]
胚胎发育时期鼠原肠运动期间整合信号网络的构想与理解
Rhanna R Haantjes,Jeske Strik,Joëlle de Visser et al.
Rhanna R Haantjes et al.
At the onset of mammalian gastrulation, secreted signalling molecules belonging to the Bmp, Wnt, Nodal and Fgf signalling pathways induce and pattern the primitive streak, marking the start for the cellular rearrangements that generate the ...
Sall1 regulates microtubule acetylation in mesenchymal cells during mouse urethral development [0.03%]
Sall1在小鼠尿道发育过程中调节间充质细胞微管乙酰化
Alvin R Acebedo,Gen Yamada,Mellissa C Alcantara et al.
Alvin R Acebedo et al.
Male embryonic external genitalia (eExG) undergo sexually dimorphic urethral development in response to androgen signaling (urethral masculinization). Whereas androgen is an essential masculinization factor for eExG, the specific molecular ...
Definition of the characteristic neurogenesis pattern in the neural plate by the Hes1 orthologue gene, her6, during early zebrafish development [0.03%]
Hes1同源基因her6定义了斑马鱼早期发育中神经板中的特征性神经生成模式
Momo Tsuruoka,Hiroki Tokizaki,Kyo Yamasu
Momo Tsuruoka
During vertebrate embryonic development, a distinctive, spotty neurogenesis pattern emerges in the early neural plate, which represents proneural clusters. The determination of this pattern depends on the interaction between proneural genes...
Generation of kidney organoids derived from human expanded potential stem cells [0.03%]
由人类扩展潜能干细胞衍生的肾脏类器官的生成
Zhanpeng Kuang,Changmiao Pang,Haiyan Wang et al.
Zhanpeng Kuang et al.
The establishment of human expanded potential stem cell (hEPSC) presents a unique cellular platform for translational research in kidney organoids. We generated SIX2 reporter and doxycycline (DOX)-inducible YAP overexpression in hEPSC lines...
Self-organization of an organizer: Whole-body regeneration from reaggregated cells in cnidarians [0.03%]
无器官组织的自我组织：刺胞动物整个身体再生来源于再聚集细胞
Sanjay Narayanaswamy,Ulrich Technau
Sanjay Narayanaswamy
Cnidarians like the freshwater polyp Hydra and the sea anemone Nematostella, are famous for their enormous capacity to regenerate missing head or feet upon bisection. Classical transplantation experiments have demonstrated that the hypostom...
Extracellular matrix in cardiac morphogenesis, fibrosis, and regeneration [0.03%]
心脏形态发生、纤维化和再生中的细胞外基质
Ashwini Punde,Amey Rayrikar,Shreya Maity et al.
Ashwini Punde et al.
The extracellular matrix (ECM) plays a crucial role in providing structural integrity and regulating cell communication essential for organ development, homeostasis, and regeneration, including hearts. Evidence indicates that disruptions in...