Sall1 regulates microtubule acetylation in mesenchymal cells during mouse urethral development [0.03%]
Sall1在小鼠尿道发育过程中调节间充质细胞微管乙酰化
Alvin R Acebedo,Gen Yamada,Mellissa C Alcantara et al.
Alvin R Acebedo et al.
Male embryonic external genitalia (eExG) undergo sexually dimorphic urethral development in response to androgen signaling (urethral masculinization). Whereas androgen is an essential masculinization factor for eExG, the specific molecular ...
Definition of the characteristic neurogenesis pattern in the neural plate by the Hes1 orthologue gene, her6, during early zebrafish development [0.03%]
Hes1同源基因her6定义了斑马鱼早期发育中神经板中的特征性神经生成模式
Momo Tsuruoka,Hiroki Tokizaki,Kyo Yamasu
Momo Tsuruoka
During vertebrate embryonic development, a distinctive, spotty neurogenesis pattern emerges in the early neural plate, which represents proneural clusters. The determination of this pattern depends on the interaction between proneural genes...
Generation of kidney organoids derived from human expanded potential stem cells [0.03%]
由人类扩展潜能干细胞衍生的肾脏类器官的生成
Zhanpeng Kuang,Changmiao Pang,Haiyan Wang et al.
Zhanpeng Kuang et al.
The establishment of human expanded potential stem cell (hEPSC) presents a unique cellular platform for translational research in kidney organoids. We generated SIX2 reporter and doxycycline (DOX)-inducible YAP overexpression in hEPSC lines...
Self-organization of an organizer: Whole-body regeneration from reaggregated cells in cnidarians [0.03%]
无器官组织的自我组织：刺胞动物整个身体再生来源于再聚集细胞
Sanjay Narayanaswamy,Ulrich Technau
Sanjay Narayanaswamy
Cnidarians like the freshwater polyp Hydra and the sea anemone Nematostella, are famous for their enormous capacity to regenerate missing head or feet upon bisection. Classical transplantation experiments have demonstrated that the hypostom...
Extracellular matrix in cardiac morphogenesis, fibrosis, and regeneration [0.03%]
心脏形态发生、纤维化和再生中的细胞外基质
Ashwini Punde,Amey Rayrikar,Shreya Maity et al.
Ashwini Punde et al.
The extracellular matrix (ECM) plays a crucial role in providing structural integrity and regulating cell communication essential for organ development, homeostasis, and regeneration, including hearts. Evidence indicates that disruptions in...
Lila Neahring,Jennifer A Zallen
Lila Neahring
Epithelia are ubiquitous tissues with essential structural, signaling, and barrier functions. How individual cells act collectively to assemble and remodel epithelia throughout development is a fundamental question in developmental biology....
Temporal regulation of endoderm convergence and extension by the BMP activity gradient through mesoderm-dependent and independent mechanisms [0.03%]
BMP活性梯度通过中胚层依赖和非依赖机制对内胚层聚合和延伸的时相调控
Chia-Teng Chang,Tony Tsai,Lila Solnica-Krezel
Chia-Teng Chang
One hundred years ago, Spemann and Mangold identified the organizer, a critical embryonic region that establishes vertebrate body axes by directing cell fate and morphogenesis. A conserved vertebrate mechanism involves the regulation of a v...
Transcending the hegemony of the molecular machine through an organic renewal of biology and biomedicine [0.03%]
通过生物学和生物医学的有机更新超越分子机器的霸权
Amy E Shyer,Alan R Rodrigues
Amy E Shyer
The dominant approach to the study of living systems in the 20th century into today has been that of a reductionist approach focused on genetics and biochemistry. The hunt for genes and the elucidation of their biochemical outputs has organ...
Jing Chen,Anming Meng
Jing Chen
The establishment of the body axis and developmental blueprint in embryos has remained to be a central question in developmental biology, captivating scientists for centuries. A milestone in this field was achieved in 1924 when Hans Spemann...
Mucociliary cell type compositions - bridging the gap between genes and emergent tissue functions [0.03%]
黏液纤毛细胞类型的组成--在基因与组织功能之间建立联系
Peter Walentek
Peter Walentek
When multiple cell types are brought together to form a tissue-specific collective, the combination of cell functions and cell-cell interactions leads to novel behaviors and properties beyond the simple addition of individual features, ofte...