5-Azacytidine pretreatment confers transient upregulation of proliferation and stemness in human mesenchymal stem cells [0.03%]
5-氮杂胞苷预处理可暂时提升人骨髓间充质干细胞的增殖和干性
Agnes Lee Chen Ong,Sau Har Lee,Shuh Wen Aung et al.
Agnes Lee Chen Ong et al.
Successful outcomes of cell-based therapeutic is highly-dependent on quality and quantity of the cells. Epigenetic modifiers are known to modulate cell fates via reprogramming, hence it is plausible to use them in enhancing the plasticity o...
Dysregulation of Rho GTPases in orofacial cleft patients-derived primary cells leads to impaired cell migration, a potential cause of cleft/lip palate development [0.03%]
口面部裂患者来源的原代细胞中Rho GTP酶失调导致细胞迁移受损，可能是唇裂发生的潜在原因
Mirvat El-Sibai,Joelle El Hajj,Maria Al Haddad et al.
Mirvat El-Sibai et al.
Cleft lip and/or palate are a split in the lip, the palate or both. This results from the inability of lip buds and palatal shelves to properly migrate and assemble during embryogenesis. By extracting primary cells from a cleft patient, we ...
Case Reports
Cells & development. 2021 Mar:165:203656. DOI:10.1016/j.cdev.2021.203656 2021
Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization [0.03%]
Usp22在小鼠早期妊娠子宫表达并参与子宫内膜间充质细胞蜕膜化过程
Yaqin Wang,Yue Gao,Chan Zhou et al.
Yaqin Wang et al.
While decidualization is essential for embryo implantation in the context of a normal pregnancy, the molecular basis for this process remains poorly understood. Ubiquitin-specific protease 22 (Usp22), one of the deubiquitinating enzymes, is...
Deterministic role of sonic hedgehog signalling pathway in specification of hemogenic versus endocardiogenic endothelium from differentiated human embryonic stem cells [0.03%]
sonic hedgehog信号通路在调控人胚胎干细胞分化为造血内皮细胞和心内膜细胞过程中的决定性作用
Prasad Pethe,Vinnie Sharon Noel,Vaijayanti Kale
Prasad Pethe
Embryonic stem cells (ESCs) have been shown to have an ability to form a large number of functional endothelial cells in vitro, but generating organ-specific endothelial cells remains a challenge. Sonic hedgehog (SHH) pathway is one of the ...
Zebrafish twist2/dermo1 regulates scale shape and scale organization during skin development and regeneration [0.03%]
斑马鱼twist2/dermo1在皮肤发育和再生过程中调节鳞片形状和鳞片排列
Tressa Jacob,Antara Chakravarty,Ankita Panchal et al.
Tressa Jacob et al.
Scales are skin appendages in fishes that evolutionarily predate feathers in birds and hair in mammals. Zebrafish scales are dermal in origin and develop during metamorphosis. Understanding regulation of scale development in zebrafish offer...
Brenda Canales Coutiño,Roberto Mayor
Brenda Canales Coutiño
Cellular processes are initiated and regulated by different stimuli, including mechanical forces. Cell membrane mechanosensors represent the first step towards the conversion of mechanical stimuli to a biochemical or electrical response. Me...
Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish [0.03%]
脊椎动物GAGA相关因子(vGAF)在斑马鱼早期发育中的作用研究
Navneet K Matharu,Sonu Yadav,Megha Kumar et al.
Navneet K Matharu et al.
Homeotic genes and their genomic organization show remarkable conservation across bilaterians. Consequently, the regulatory mechanisms, which control hox gene expression, are also highly conserved. The crucial presence of conserved GA rich ...
Tatiana Solovieva,Marianne Bronner
Tatiana Solovieva
Schwann cell precursors (SCPs) are a transient population in the embryo, closely associated with nerves along which they migrate into the periphery of the body. Long considered to be progenitors that only form Schwann cells-the myelinating ...
Perinatal exposure to chlorpyrifos and/or a high-fat diet is associated with liver damage in male rat offspring [0.03%]
孕期接触氯氰聚酯和/或高脂饮食与雄性大鼠幼崽肝损伤相关
Marion Guibourdenche,Hiba El Khayat El Sabbouri,Fidéline Bonnet et al.
Marion Guibourdenche et al.
Metabolic impairments in childhood are known to promote the development of type 2 diabetes and/or obesity in adulthood. These impairments may result from perinatal exposure to harmful environmental factors, such as pesticide residues or the...
Slit2 is necessary for optic axon organization in the zebrafish ventral midline [0.03%]
slit2在斑马鱼脑的腹侧基板中对视神经轴突排列是必需的
Camila Davison,Flavio R Zolessi
Camila Davison
Slit-Robo signaling has been implicated in regulating several steps of retinal ganglion cell axon guidance, with a central role assigned to Slit2. We report here the phenotypical characterization of a CRISPR-Cas9-generated zebrafish null mu...