Signalling molecules and microenvironment modulation in skin regeneration of chronic wound repair: A cellular perspective [0.03%]
慢性伤口修复过程中皮肤再生的信号分子及微环境调控：细胞层面的视角
Keren Celestina Mendonce,Naveen Palani,P Monisha et al.
Keren Celestina Mendonce et al.
Tissue repair is an intricate biological process involving cellular and molecular mechanisms. These mechanisms coordinate the repair of damaged tissue, relying on the function of several signalling molecules. Growth factors, cytokines, and ...
Morphogenetic constraints in the development of gastruloids: Implications for mouse gastrulation [0.03%]
关于类胚胎发育的形态发生限制：对小鼠原肠运动的意义
U M Fiuza,S Bonavia,P Pascual-Mas et al.
U M Fiuza et al.
Mammalian embryonic size is tightly controlled with checkpoints and compensatory mechanisms correcting size defects. Here, we take advantage of gastruloids, a stem cell embryoid system not subject to most size controls, to study the role of...
Endothelial differentiation of Oral cavity-derived mesenchymal stem/stromal cells [0.03%]
口腔来源的间充质干细胞向内皮细胞分化
Wen Jun Thang
Wen Jun Thang
A rapid construction of vasculature ensures the survival and proper functions of tissue-engineered constructs for oral and craniofacial tissue regeneration. Vascularization achieved via a co-culture system containing endothelial cells (ECs)...
Coordinating tissue development to build body and brain: Lessons from the gastrula organiser and its derivatives [0.03%]
协调组织发育以构建机体和大脑：来自原肠胚形成器及其衍生物的启示
Alexandra Neaverson,Benjamin Steventon
Alexandra Neaverson
The Spemann-Mangold organiser has been a central paradigm in developmental biology for over a century, primarily studied through its ability to induce secondary axes in transplantation experiments. However, how the organiser and its derivat...
Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner [0.03%]
母体肥胖通过饮食和性别特异性的方式改变后代寿命和免疫反应的表观遗传编程作用研究
Seyhmus Bayar,Lea Seep,Karolina Doubková et al.
Seyhmus Bayar et al.
Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative disorders. To investigate the intergenerational effects of maternal obesity, we used Drosophi...
The characterization of the biological effect of hypoxia-mimetic condition on angiogenic potential in mesenchymal stem cells derived from different origins [0.03%]
低氧诱导不同来源间充质干细胞血管生成潜能的表征研究
Yeo Gyun Yun,Donghyeon Yeo,Trang Thanh Thien Tran et al.
Yeo Gyun Yun et al.
Under physiological conditions, adult stem cells are located in a special microenvironment, known as the niche, which is characterized by low oxygen levels. Hypoxia is a crucial factor regulating stem cell behavior, and in vitro normoxic cu...
Zishuo Xu,Ansar Hussain,Hanwei Jiang et al.
Zishuo Xu et al.
A-kinase anchoring proteins (AKAPs) constitute a structurally diverse family of scaffold proteins with significant functional relevance. Various AKAP family members localize to distinct subcellular compartments, such as sperm flagella, via ...
A modular organization of mammalian gastrulation and the Spemann-Mangold organizer [0.03%]
哺乳动物原肠运动的模块化组织及其斯佩曼-孟加顿组织中心
Alfonso Martinez Arias,André Dias,Alexandra E Wehmeyer et al.
Alfonso Martinez Arias et al.
Studies in amphibian embryos revealed the existence of groups of cells, organizers, that play a central role in laying down the body plan. One, the Spemann-Mangold Organizer (SMO) is associated with the induction of the nervous system and t...
A comparative analysis of the chorioallantoic membrane as an experimental model to study angiogenesis and vascular development in the chick and quail embryos [0.03%]
鸡和鹌鹑胚胎中血发育研究的合体膜实验模型比较分析
Domenico Ribatti
Domenico Ribatti
The avian embryo is a model in which experimental embryology and cellular and molecular biology techniques can converge to address fundamental questions of development biology. Chick and quail have been powerful partners in the investigatio...
Towards an integrated view and understanding of embryonic signalling during murine gastrulation [0.03%]
胚胎发育时期鼠原肠运动期间整合信号网络的构想与理解
Rhanna R Haantjes,Jeske Strik,Joëlle de Visser et al.
Rhanna R Haantjes et al.
At the onset of mammalian gastrulation, secreted signalling molecules belonging to the Bmp, Wnt, Nodal and Fgf signalling pathways induce and pattern the primitive streak, marking the start for the cellular rearrangements that generate the ...