Head organizer: Cerberus and IGF cooperate in brain induction in Xenopus embryos [0.03%]
主要组织者：Cerberus和IGF合作诱导Xenopus胚胎发生脑部发育
Yagmur Azbazdar,Edgar M Pera,Edward M De Robertis
Yagmur Azbazdar
Neural induction by cell-cell signaling was discovered a century ago by the organizer transplantations of Spemann and Mangold in amphibians. Spemann later found that early dorsal blastopore lips induced heads and late organizers trunk-tail ...
Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells [0.03%]
小鼠上皮细胞中基底膜矩阵mRNA的微管依赖性顶极化
Shaohe Wang,Kazue Matsumoto,Madison M Mehlferber et al.
Shaohe Wang et al.
The basement membrane (BM) demarcating epithelial tissues undergoes rapid expansion to accommodate tissue growth and morphogenesis during embryonic development. To facilitate the secretion of bulky BM proteins, their mRNAs are polarized bas...
Never-ending story of Brachyury: From short-tailed mice to tailless primates [0.03%]
Brachyury基因与尾巴进化的前世今生：从短尾鼠想到无尾猴
Vladimir Korzh
Vladimir Korzh
The history of developmental biology starts from the almost simultaneous discoveries of the Organizer of axial structures in amphibians by Spemann and Mangold in Freiburg and of the Brachyury mutant in mammals by the Dobrovolskaya-Zavadskay...
Flexural rigidity of pressurized model notochords in regular packing patterns [0.03%]
规则排列模式下受压模型脊索的弯曲刚度
Evan J Curcio,Sharon R Lubkin
Evan J Curcio
The biomechanics of embryonic notochords are studied using an elastic membrane model. An initial study varying internal pressure and stiffness ratio determines tension and geometric ratios as a function of internal pressure, membrane stiffn...
The transcription factor AP2 and downstream genes shared by asexual reproduction and zooidal regeneration in the tunicate, Polyandrocarpa misakiensis [0.03%]
半斯氏樽海鞘无性繁殖和芽球再生共有的转录因子AP2及下游基因
Kaz Kawamura,Shigeki Fujiwara
Kaz Kawamura
Epithelial outpocketing, tunic softening, mesenchymal cell death, dedifferentiation/transdifferentiation, and resistance to environmental stress are major events that occur during asexual reproduction by budding in the tunicate, Polyandroca...
Prelude to molecularization: The double gradient model of Sulo Toivonen and Lauri Saxén [0.03%]
分子化之前的序章：Sulo Toivonen 和Lauri Saxén的双重梯度模型
Scott F Gilbert
Scott F Gilbert
The present molecular investigations of Organizer phenomena show a remarkable connection to the earlier classical embryological studies that used transplantation as a method for making mechanistic models of induction. One of the most promin...
γH2AX in mouse embryonic stem cells: Distribution during differentiation and following γ-irradiation [0.03%]
γH2AX在小鼠胚胎干细胞中的分布：分化过程中和受到γ射线照射后的分布状况
Tom C Karagiannis,Christian Orlowski,Katherine Ververis et al.
Tom C Karagiannis et al.
Phosphorylated histone H2AX (γH2AX) represents a sensitive molecular marker of DNA double-strand breaks (DSBs) and is implicated in stem cell biology. We established a model of mouse embryonic stem cell (mESC) differentiation and examined ...
The extracellular matrix in tissue morphogenesis: No longer a backseat driver [0.03%]
细胞外基质在组织形态建成中的作用：不再只是辅助角色
María-Del-Carmen Díaz-de-la-Loza,Brian M Stramer
María-Del-Carmen Díaz-de-la-Loza
The forces driving tissue morphogenesis are thought to originate from cellular activities. While it is appreciated that extracellular matrix (ECM) may also be involved, ECM function is assumed to be simply instructive in modulating the cell...
Roberto Mayor
Roberto Mayor
17β-estradiol mitigates the inhibition of SH-SY5Y cell differentiation through WNT1 expression [0.03%]
雌二醇通过WNT1表达缓解对SH-SY5Y细胞分化抑制作用的影响
Rubina Shakya,Prateep Amonruttanapun,Tanapol Limboonreung et al.
Rubina Shakya et al.
17β-estradiol (E2) and canonical WNT-signaling represent crucial regulatory pathways for microtubule dynamics and synaptic formation. However, it is unclear yet whether E2-induced canonical WNT ligands have significant impact on neurogenic...