The significance of Ethel Browne's research on Hydra for the organizer concept [0.03%]
Ethel Browne对水螅的研究对于组织者概念的意义
Thomas W Holstein
Thomas W Holstein
This article focuses on the roots of the organizer concept, which was developed by Hans Spemann during his studies of early embryonic development in amphibians. The fundamental properties of this axis-inducing signaling center have been elu...
Qinghai Zhang,Pei Zhang,Min Yang et al.
Qinghai Zhang et al.
The Notch signaling pathway, an evolutionarily highly conserved pathway, participates in various essential physiological processes in organisms. Activation of Notch signaling in the canonical manner requires the combination of ligand and re...
Andreas von Bubnoff
Andreas von Bubnoff
This paper analyzes the influence of Hans Spemann and Hilde Mangold's discovery of the embryonic organizer on society outside the narrower confines of embryology. It begins by overviewing how in the 1920s-1930s, the organizer discovery fit ...
Maral J Rouhani,Sam M Janes,Carla F Kim
Maral J Rouhani
The upper airway acts as a conduit for the passage of air to the respiratory system and is implicated in several chronic diseases. Whilst the cell biology of the distal respiratory system has been described in great detail, less is known ab...
Therapeutic approaches of cell therapy based on stem cells and terminally differentiated cells: Potential and effectiveness [0.03%]
基于干细胞和完全分化细胞的细胞治疗的治疗方法：潜力与功效
Ali Pirsadeghi,Negar Namakkoobi,Mahtab Sharifzadeh Behzadi et al.
Ali Pirsadeghi et al.
Cell-based therapy, as a promising regenerative medicine approach, has been a promising and effective strategy to treat or even cure various kinds of diseases and conditions. Generally, two types of cells are used in cell therapy, the first...
Makoto Asashima,Yumeko Satou-Kobayashi
Makoto Asashima
The discovery of the Spemann-Mangold organizer strongly influenced subsequent research on embryonic induction, with research aiming to elucidate the molecular characteristics of organizer activity being currently underway. Herein, we review...
Morphoelastic models discriminate between different mechanisms of left-right asymmetric stomach morphogenesis [0.03%]
形态弹性模型区分胃左-右不对称形态发生的不同机制
Ariel N Nikas,Evan J Curcio,Nanette Nascone-Yoder et al.
Ariel N Nikas et al.
The mechanisms by which the vertebrate stomach undergoes its evolutionarily conserved leftward bending remain incompletely understood. Although the left and right sides of the organ are known to possess different gene expression patterns an...
Reactive nitrogen species-mediated cell proliferation during tail regeneration and retinoic acid as a putative modulator of tissue regeneration in the geckos [0.03%]
反应性氮类介导的细胞增殖在壁虎尾巴再生中的作用及维甲酸作为潜在组织再生调节因子的可能性
A Sarada Achary,Cuckoo Mahapatra
A Sarada Achary
Reactive nitrogen species (RNS), a mediator of nitrosative stress, plays a vital role during wound healing but its role during tissue regeneration is poorly understood. In the present study, the role of RNS was investigated post-tail autoto...
Live imaging of Fibronectin 1a-mNeonGreen and Fibronectin 1b-mCherry knock-in alleles during early zebrafish development [0.03%]
早期斑马鱼发育过程中纤维连接蛋白1a-mNeonGreen和纤维连接蛋白1b-mCherry基因敲入等位基因的活体成像技术研究
Dörthe Jülich,Scott A Holley
Dörthe Jülich
Within the developing embryo, cells assemble and remodel their surrounding extracellular matrix during morphogenesis. Fibronectin is an extracellular matrix glycoprotein and is a ligand for several members of the Integrin adhesion receptor ...
The RhoGEF Trio is transported by microtubules and affects microtubule stability in migrating neural crest cells [0.03%]
RhoGEF三重奏由微管运输，并影响迁移的神经嵴细胞中的微管稳定性
Stefanie Gossen,Sarah Gerstner,Annette Borchers
Stefanie Gossen
Directed cell migration requires a local fine-tuning of Rho GTPase activity to control protrusion formation, cell-cell contraction, and turnover of cellular adhesions. The Rho guanine nucleotide exchange factor (GEF) TRIO is ideally suited ...