AZIN2 is associated with apoptosis of germ cells in undescended testis [0.03%]
AZIN2与睾丸未降导致的生精细胞凋亡相关
Yuanyuan Gao,Shumin Xu,Jiajun Qiao et al.
Yuanyuan Gao et al.
Undescended testis (UDT), known as cryptorchidism (CRY), is a common congenital disorder in which one or both testicles do not descend normally into the scrotum. A unilateral UDT model was established by inducing UDT in mice through surgery...
Epigenetic inheritance of acquired traits via stem cells dedifferentiation/differentiation or transdifferentiation cycles [0.03%]
通过干细胞去分化/再分化或转分化的周期获得性状的表观遗传学传递
Arshak R Alexanian
Arshak R Alexanian
Inheritance of acquired characteristics is the once widely accepted idea that multiple modifications acquired by an organism during its life, can be inherited by the offspring. This belief is at least as old as Hippocrates and became popula...
Ex vivo organotypic bone slice culture reveals preferential chondrogenesis after sustained growth plate injury [0.03%]
持续生长板损伤后的类器官型骨切片培养显示软骨生成优先发生
Vanessa Etschmaier,Muammer Üçal,Birgit Lohberger et al.
Vanessa Etschmaier et al.
Postnatal bone growth primarily relies on chondrocyte proliferation and osteogenic differentiation within the growth plate (GP) via endochondral ossification. Despite its importance, the GP is vulnerable to injuries, affecting 15-30 % of bo...
Evaluating neural crest cell migration in a Col4a1 mutant mouse model of ocular anterior segment dysgenesis [0.03%]
评估Col4a1突变小鼠模型中眼部前段发育不全的神经嵴细胞迁移能力
Corinna Cozzitorto,Zoe Peltz,Lourdes M Flores et al.
Corinna Cozzitorto et al.
The periocular mesenchyme (POM) is a transient migratory embryonic tissue derived from neural crest cells (NCCs) and paraxial mesoderm that gives rise to most of the structures in front of the eye. Morphogenetic defects of these structures ...
Reprint of: Prelude to molecularization: The double gradient model of Sulo Toivonen and Lauri Saxén [0.03%]
索罗·图伊沃宁和劳里·萨克斯恩的双重梯度模型：分子化之前的序曲
Scott F Gilbert
Scott F Gilbert
The present molecular investigations of Organizer phenomena show a remarkable connection to the earlier classical embryological studies that used transplantation as a method for making mechanistic models of induction. One of the most promin...
Xenopus tropicalis osteoblast-specific open chromatin regions reveal promoters and enhancers involved in human skeletal phenotypes and shed light on early vertebrate evolution [0.03%]
Xenopus tropicalis成骨细胞特异性开放染色质区域揭示参与人类骨骼表型的启动子和增强子并阐明早期脊椎动物进化问题
Héctor Castillo,Patricia Hanna,Laurent M Sachs et al.
Héctor Castillo et al.
While understanding the genetic underpinnings of osteogenesis has far-reaching implications for skeletal diseases and evolution, a comprehensive characterization of the osteoblastic regulatory landscape in non-mammalian vertebrates is still...
Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis [0.03%]
鸟类皮肤发育过程中的血管网络适应性图案化：间充质可塑性和真皮血管发生
Kuang-Ling Ou,Chih-Kuan Chen,Junxiang J Huang et al.
Kuang-Ling Ou et al.
A vasculature network supplies blood to feather buds in the developing skin. Does the vasculature network during early skin development form by sequential sprouting from the central vasculature or does local vasculogenesis occur first that ...
Collagen IV assembly is influenced by fluid flow in kidney cell-derived matrices [0.03%]
肾脏细胞来源基质中的IV型胶原装配受流体流动影响
Pinyuan Tian,Nikki-Maria Koudis,Mychel R P T Morais et al.
Pinyuan Tian et al.
Kidney podocytes and endothelial cells assemble a complex and dynamic basement membrane that is essential for kidney filtration. Whilst many components of this specialised matrix are known, the influence of fluid flow on its assembly and or...
Celebrating the centennial of the most famous experiment in embryology: Hilde Mangold, Hans Spemann and the organizer [0.03%]
庆祝胚胎学最著名的实验百年纪念：希尔德·芒戈尔德、汉斯·斯佩曼与组织者效应
Edward M De Robertis,Wolfgang Driever,Roberto Mayor
Edward M De Robertis
This Issue of Cells & Development celebrates the centennial of the Spemann-Mangold organizer experiment. This was the most famous experiment in embryology and its reverberations have greatly influenced developmental biology. This historical...
Brain enlargement with rostral bias in larvae from a spontaneously occurring female variant line of Xenopus; role of aberrant embryonic Wnt/β-catenin signaling [0.03%]
非洲爪蟾雌性突变体品系自发产生的幼体脑增大现象及其胚胎Wnt/β-连环蛋白信号异常的作用机制
Ikuko Hongo,Chihiro Yamaguchi,Harumasa Okamoto
Ikuko Hongo
Increased brain size and its rostral bias are hallmarks of vertebrate evolution, but the underlying developmental and genetic basis remains poorly understood. To provide clues to understanding vertebrate brain evolution, we investigated the...