Evaluation of chromatin accessibility in cultured fetal hypothalamic neuroprogenitors following maternal protein restriction in rats [0.03%]
大鼠母体蛋白摄入量受限后评估培养的胎儿下丘脑神经前体细胞染色质可及性
Valérie Amarger,Morgane Frapin,Pieter Vancamp
Valérie Amarger
Maternal protein restriction (PR) is a risk factor for altered fetal neurodevelopment and increased susceptibility to neurometabolic disorders later in life. Although structural and transcriptomic changes in the developing hypothalamus have...
Eric Flores-Hernández,Grace Binder,Hui Chen et al.
Eric Flores-Hernández et al.
The Wnt/β-catenin signaling pathway is a deeply conserved regulatory network that governs embryonic development, stem cell maintenance, and tissue homeostasis. Aberrant activation of the Wingless/Integrated protein (Wnt) signaling is a hal...
Samd7 is dispensable for spermatogenesis and male fertility in mice [0.03%]
Samd7在小鼠精子发生和雄性生育力中的非必需性
Dan Zhao,Xuan Ma,Yueqin Liu et al.
Dan Zhao et al.
Background: Although many genes have been implicated in spermatogenesis, their precise relationships to male fertility remain unclear. Here, we investigated the in vivo importance of the highly conserved, testis-enriched ...
Estetrol potentiates progesterone-driven growth restraint while blunting pro-angiogenic activation in murine endometriosis lesions [0.03%]
雌激素类似物estetrol通过增强孕酮的抗增殖作用同时抑制促血管生成活化来改善小鼠子宫内膜异位病灶
Gabriel Maldonado,Cristian Espinoza,Anna Arias et al.
Gabriel Maldonado et al.
Background: Endometriosis is sustained by ectopic endometrial implants that remain proliferative and vascularized, making endocrine modulation a cornerstone of therapy. Estetrol (E4) an endogenous estrogen produced during...
Transcriptomic signatures and neural cell composition in schizophrenia iPSC-derived neuron cultures [0.03%]
精神分裂症诱导多能干细胞来源神经细胞系的转录组标志和神经元组成
Bárbara S Casas,Jorge Zúñiga,Sebastián Arizábalos et al.
Bárbara S Casas et al.
Schizophrenia is a neurodevelopmental disorder associated with alterations in neuronal function and connectivity. It has been extensively modeled using neurons derived from induced pluripotent stem cells (iPSC), where significant difference...
Upregulation of adenylyl cyclase 1 is crucial for osteogenic and adipogenic differentiation of MSCs [0.03%]
腺苷酸环化酶1的上调对间充质干细胞成骨和成脂分化至关重要
Vladimir Usachev,Nikita Voloshin,Alexandra Primak et al.
Vladimir Usachev et al.
Introduction: Adenylyl cyclase (AC) is an important enzyme that mediates stem cells' response to hormonal stimuli. Despite the fact that currently there are ten described isoforms of AC little is known about their individ...
Fabian Gärtner,Lale Alpar,Yohanns Bellaïche
Fabian Gärtner
Toll-like receptors (TLRs) were first identified as developmental cues that establish the dorsal-ventral axis in Drosophila. This discovery was followed by the recognition of their central role in invertebrate and vertebrate innate immunity...
Lily Acker,Hui Chen
Lily Acker
Breast Cancer Gene 1 (BRCA1) is a critical regulator of genome integrity whose dysfunction greatly increases lifetime risk of breast and ovarian cancers. While BRCA1 has been extensively studied in the contexts of adult biology and cancer, ...
The face you're born with: How early development dictates a lifetime of expression and ageing [0.03%]
与生俱来的那张脸：早期发育决定了一生的表情和衰老过程
Eqram Rahman,Parinitha Rao,Golam Saklayen et al.
Eqram Rahman et al.
Facial ageing manifests in highly consistent, topologically predictable patterns, including nasolabial folds and tear troughs, despite wide inter-individual variation in anatomy and soft-tissue volume loss. Current clinical models emphasise...
Inhibition of circNUP93 (hsa_circ_0039480) activates the IRS-1/Akt pathway and alleviates insulin resistance in gestational diabetes mellitus via the MiR-767-3p/HIF1A axis [0.03%]
circNUP93（hsa_circ_0039480）通过MiR-767-3p/HIF1A轴抑制激活IRS-1/Akt通路并缓解妊娠期糖尿病患者的胰岛素抵抗
Xiao Chen,Hong Yang,Anna Zhao et al.
Xiao Chen et al.
Gestational diabetes mellitus (GDM) is characterized by insulin resistance (IR) and impaired glucose tolerance during pregnancy, yet the upstream regulatory mechanisms controlling insulin signaling remain unclear. The circular RNA hsa_circ_...