Levodopa exerts neuroprotective effects by suppressing microglial proinflammatory activation in a rat hemi-Parkinson's disease model [0.03%]
左旋多巴通过抑制帕金森病半脑模型中微胶质细胞促炎症活化而发挥神经保护作用
Noriyuki Miyaue,Mohammed E Choudhury,Ikuko Takeda et al.
Noriyuki Miyaue et al.
Levodopa is a central medicine used for the treatment of Parkinson's disease (PD) as a dopamine (DA) precursor that increases DA levels in the striatum. Microglia, resident macrophages in the brain, become activated in response to the progr...
The influence of mesenchymal stem cells on the severity of hypoxic-ischemic brain damage in neonatal rats via serum cytokines [0.03%]
胎鼠间充质干细胞通过血清细胞因子影响缺氧缺血性脑损伤严重程度的作用研究
Sifeng Yue,Feng Lin,Zenghong Huang et al.
Sifeng Yue et al.
Background: Neonatal hypoxic-ischemic brain damage (Hypoxic‑Ischemic Brain Damage, HIBD) is a severe neurological disorder caused by perinatal asphyxia. Its severe long-term sequelae impose a heavy burden on families and...
Losartan attenuates depression-like behavior in epileptic rats by regulating the TGF-β/Smad signaling [0.03%]
洛萨坦通过调节TGF-β/Smad信号通路缓解癫痫模型大鼠的抑郁样行为
Penghui Cao,Shichuan Shen,Ziyan Fang et al.
Penghui Cao et al.
Objective: This study aims to investigate the role of the TGF-β/Smad Signaling in depression comorbidity in epileptic individuals and to evaluate the effect of losartan on depressive symptoms. ...
Audrey M Blazek Ramsay,Eoin P Flanagan,Elizabeth A Coon et al.
Audrey M Blazek Ramsay et al.
Background: Multiple system atrophy (MSA) is an α-synucleinopathy characterized by prominent cerebellar or parkinsonian features. This is pathologically due to the deposition of α-synuclein in glial cells, the mechanism...
Citalopram-induced decrease of CLOCK-ir and BMAL1-ir kisspeptin neurons in the anteroventral periventricular nucleus of adult male mice [0.03%]
舍曲林诱导的小鼠前脑室周核CLOCK-ir和BMAL1-ir亲吻肽能神经元减少
Manish Putteeraj,Tomoko Soga,Ishwar S Parhar
Manish Putteeraj
A complex network exists between the reproductive, circadian and the serotonergic system. Modulation of brain serotonin levels triggers sexual irregularities and alters circadian behaviour. This study investigated the presence of an endogen...
Behavioral and physiological benefits of alpha-pinene in adult rats experiencing chronic stress: A focus on depression and oxidative stress [0.03%]
α-蒎烯对慢性应激成年大鼠的行为和生理效益：重点关注抑郁和氧化应激
Seyed Shahriyar Hosseini,Zohreh Ghotbeddin,Seyed Reza Fatemi Tabatabaei et al.
Seyed Shahriyar Hosseini et al.
To investigate the protective effects of alpha-pinene, an antioxidant compound, on depressive-like behaviors, social interactions, and biochemical markers in adult rats exposed to chronic stress through maternal separation during early deve...
Electroacupuncture enhances nerve regeneration and functional recovery in a rat model of median nerve transection [0.03%]
电针可促进完全横断正中神经的雪旺细胞增殖及轴突再生
Hongyu Zhou,Jin He,Ainizier Yalikun et al.
Hongyu Zhou et al.
Objective: To investigate the therapeutic efficacy and underlying mechanisms of electroacupuncture (EA) in promoting peripheral nerve regeneration following delayed repair of a median nerve transection in a rat model. ...
Circulating microRNA-219 in stroke: Lack associations with clinical parameters and post-stroke epilepsy risk [0.03%]
中风患者外周血微小核糖核酸-219与临床参数及中风后癫痫风险无关
Zeynab Fahimi,Mohammad Kazemi,Habibollah Rahimi et al.
Zeynab Fahimi et al.
Background: Post-stroke epilepsy (PSE) is a significant complication in stroke survivors, yet early diagnostic biomarkers remain unclear. This study investigated whether circulating microRNA-219 (miR-219) could serve as a...
TMEM206 gene knockout improves balance performance in SCA1 transgenic mice [0.03%]
TMEM206基因敲除可改善小脑萎缩症1型转基因小鼠的平衡能力
Jia-Hui Zhang,Yu Qin,Shun-Chang Sun
Jia-Hui Zhang
TMEM206 was identified as a conserved chloride channel that underlies widely expressed, proton-activated, outwardly rectifying chloride currents. Spinocerebellar ataxia type 1 (SCA1) is one of polyglutamine diseases, and is characterized as...
Effects of different light spectra on locomotion, anxiety, and heart rate in spontaneously hypertensive rats and Wistar-Kyoto rats [0.03%]
不同光谱对 SHR 和 WKY 大鼠运动、焦虑和心率的影响
Teng-Ching Yin,Meng-Li Tsai,Shih-Han Liao et al.
Teng-Ching Yin et al.
Light exposure plays a critical role in regulating physiological and behavioral processes. This study aimed to explore how different light spectra influence locomotor activity, anxiety-like behavior, and heart rate variability in rodents. W...