Exploring the Genetic Overlap Between Metabolic Traits and Anorexia Nervosa [0.03%]
代谢特征和神经性厌食症的遗传重叠研究
Danielle M Adams,Murray J Cairns
Danielle M Adams
Background: Anorexia nervosa (AN) is an eating disorder with complex biology that remains largely uncharacterized. Recent genome-wide association studies have identified genetic associations between metabolic traits and A...
Rare Variants in Antisense Long Noncoding RNA-Protein-Coding Gene Overlap Regions Contribute to Obsessive-Compulsive Disorder [0.03%]
反义长链非编码RNA-蛋白质编码基因重叠区域的稀有变异与强迫症有关
Seulgi Jung,Madison Caballero,Shelby Smout et al.
Seulgi Jung et al.
Background: Obsessive-compulsive disorder (OCD) is a prevalent neuropsychiatric disorder with an incompletely understood genetic basis, limiting targeted therapeutic options. Although previous rare-variant studies have pr...
Model-Based Electroencephalography Phenotyping Uncovers Distinct Neurocomputational Mechanisms Underlying Learning Impairments Across Psychopathologies [0.03%]
基于模型的脑电图表型分析揭示了跨精神病理障碍的学习损害下的不同神经计算机制
Nadja R Ging-Jehli,Rachel Rac-Lubashevsky,Krishn Bera et al.
Nadja R Ging-Jehli et al.
Background: Major depressive disorder (MDD), bipolar disorder (BP), and schizophrenia (SCZ) involve learning impairments with poorly understood mechanisms. Understanding both the similarities and differences in these mech...
DCC and the Architecture of Stress Vulnerability: A Guidance Cue for Depression [0.03%]
抑郁症的DCC和应激脆弱性架构：导向线索
Argel Aguilar-Valles
Argel Aguilar-Valles
Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity [0.03%]
临床高风险个体和健康对照个体在被动听觉Oddball任务中评估的theta振荡与临床结果及失匹配负波的关系
Jessica P Y Hua,Brian J Roach,Holly K Hamilton et al.
Jessica P Y Hua et al.
Background: Reduced mismatch negativity (MMN) is a widely replicated schizophrenia biomarker. Time-frequency analyses suggest that deficient phase synchrony and/or power of electroencephalography (EEG) event-related oscil...
Disorder-Specific Genetic Effects Drive the Associations Between Psychopathology and Cognitive Functioning [0.03%]
遗传效应驱动的心理病理与认知功能之间的关联
Wangjingyi Liao,Engin Keser,Andrea Allegrini et al.
Wangjingyi Liao et al.
Background: Cognitive functioning is a critical dimension of psychopathology that remains underinvestigated. Because cognitive deficits often transcend diagnostic boundaries, it has been challenging to delineate specific ...
Behavioral and Prefrontal Circuit Deficits in a Newly Developed Setbp1 Haploinsufficiency Mouse Model [0.03%]
新型SETBP1半定量不足小鼠模型的行为和前额叶环路缺陷
MacKenzie A Howard,Mendee A Geist,Gregory J Ordemann et al.
MacKenzie A Howard et al.
Background: SET binding protein 1 (SETBP1) regulates the cell cycle, gene transcription, and other vital intracellular processes. SETBP1 loss-of-function variants cause the neurodevelopmental disorders SETBP1-haploinsuffi...
μ Opioid Modulation of Sensorimotor Functional Connectivity in Autism: Insights From a Pharmacological Neuroimaging Investigation Using Tianeptine [0.03%]
泰安肽用于自闭症患者药理学影像研究中阿片类调节感觉运动功能连接的初步探索
Mihail Dimitrov,Nichol M L Wong,Sydney Leaman et al.
Mihail Dimitrov et al.
Background: Reproducible patterns of atypical functional connectivity (FC) of sensorimotor and higher-order networks have previously been identified in the autistic brain. However, the neurosignaling pathways underpinning...
Functional Brain Activity Associated With Intermittent Rhythmic Delta/Theta Activity: A Transdiagnostic Electroencephalography-Functional Magnetic Resonance Imaging Resting-State Study [0.03%]
与间歇性低频振荡相关的脑功能活动：一种跨诊断电生理静息态研究
Bernd Feige,Katharina von Zedtwitz,Isabelle Matteit et al.
Bernd Feige et al.
Background: Intermittent rhythmic delta/theta activity (IRDA/IRTA) detected via electroencephalography (EEG) has been implicated in the pathophysiology of neuropsychiatric illnesses. Therefore, a combined EEG and function...
Moving Beyond Self-Report in Characterizing Drug Addiction: Using Drug-Biased Behavior to Predict Treatment Completion and Dropout in Heroin-Primary, Medication-Maintained Opioid Use Disorder [0.03%]
超越自我报告来表征药物成瘾：使用药物偏置行为预测海洛因依赖性为主、用药物维持的 opioid 使用障碍患者的治疗完成和脱落率
Natalie McClain,Ahmet O Ceceli,Kathryn Drury et al.
Natalie McClain et al.
Background: Drug addiction is accompanied by enhanced salience attributed to drug over nondrug cues. This bias can be objectively measured and is reliable but underutilized in informing clinical end points, where self-rep...