Spatial Mapping of Genetic Liability to Psychiatric Disorders in the Adult Human Hippocampus [0.03%]
成人海马体中精神障碍遗传易感性的空间分布_mapping
Yusuf Baran,Darren Cameron,Adele Pryce-Roberts et al.
Yusuf Baran et al.
Background: Common genetic variants associated with psychiatric disorders are enriched in genes with high expression specificity for hippocampal neurons. However, to date, these studies have been based on measures of gene...
SARS-CoV-2 Spike Protein S1 Subunit Induces Neuroinflammation Via Microglial Kv1.3 Channel [0.03%]
新冠病毒刺突蛋白S1亚基通过活化小胶质细胞钾通道Kv1.3诱导神经炎症反应
Hee-Yoon Lee,Young Lee,Su-Hyun Jo et al.
Hee-Yoon Lee et al.
Background: Neuroinflammation is a hallmark of various neurological and psychiatric disorders, including post-COVID-19 conditions caused by SARS-CoV-2 infection. The S1 subunit of the SARS-CoV-2 spike protein (S1 protein)...
Methylome-Wide Association Studies of Physical Injury Stratified by Depression Status Assesses Exposure by Diagnosis Effects in Oxytocin Signaling and Synaptic Plasticity [0.03%]
分层分析抑郁症状况下的身体伤害的甲基化组关联研究评估了诊断暴露在催产素信号传导和突触可塑性中的作用
Sally Marshall,Rosie M Walker,Archie Campbell et al.
Sally Marshall et al.
Background: Physical injury is associated with psychological trauma and is a risk factor for major depressive disorder (MDD). DNA methylation has been suggested as a key mediator of psychopathology following trauma. ...
Developmental Alterations in the Diffusion Tensor Imaging Analysis Along the Perivascular Space Index Suggest Possible Glymphatic-Related Mechanisms Underlying Excitation/Inhibition Imbalance and Psychosis Vulnerability in 22q11.2 Deletion Syndrome [0.03%]
基于沿血管周围空间指标的扩散张量成像发育改变的异常可能反映了22q11. 2缺失综合征患者兴奋性/抑制平衡障碍及精神症状发生的甘淋巴系统的相关机制
Alessandro Pascucci,Silas Forrer,Corrado Sandini et al.
Alessandro Pascucci et al.
Background: Impairment of the glymphatic system may contribute to atypical brain development and increased vulnerability to psychiatric conditions such as psychosis. In particular, disrupted glymphatic efficiency may affe...
Neurobiological Signatures of Dyadic Transmission of Fear Extinction in Adolescent Trauma Exposure and Posttraumatic Stress [0.03%]
青少年创伤暴露和 PTSD 恐惧消退的二元传播神经生物学特征
Sara A Heyn,Samantha DiMaio,Ryan J Herringa
Sara A Heyn
Background: The use of social cues to attenuate prior learned fear associations is a critical skill for normative development. Impairments in extinction learning underlie emerging models of posttraumatic stress disorder (...
Selective Attention Dynamics in Adults With Attention-Deficit/Hyperactivity Disorder: A Role for Sensory Processing Asymmetry? [0.03%]
注意缺陷多动障碍成年人的注意力选择动力学：感觉加工不对称性的作用？
Nicolas Zink,Samantha O&#x;Connell,Samantha Betts et al.
Nicolas Zink et al.
Background: Despite persisting symptomatology in adults with attention-deficit/hyperactivity disorder (ADHD), it remains elusive whether ADHD-related impairments of selective attention are domain general or specific, whet...
Functional Magnetic Resonance Imaging Signal Typically Viewed as "Noise" Has Clinical Relevance in Psychiatry [0.03%]
通常被视为"fMRI噪声”的信号在精神病学中具有临床意义
Julia C Welsh,Cole Korponay,Tianye Zhai et al.
Julia C Welsh et al.
Background: Functional magnetic resonance imaging (fMRI) aims to identify biomarkers of neuropsychiatric illnesses, including substance use disorders; however, fMRI's clinical utility remains limited. One underexplored as...
Estradiol, Emotion Regulation, and the Limbic System: Effects on Gray Matter Volume [0.03%]
雌二醇、情绪调节和边缘系统：对灰质体积的影响
Anna Franziska Denninger,Elisa Rehbein,Inger Sundström-Poromaa et al.
Anna Franziska Denninger et al.
Background: Mastering emotion regulation is crucial for social skills and mental health. Hormonal fluctuations, particularly in estradiol (E2) levels across the menstrual cycle, significantly impact emotion processing. E2...
Reward-Related Brain Function as an Endophenotype in the Mood-Psychosis Spectrum [0.03%]
情绪障碍和精神病谱系中的奖赏相关脑功能的内表型研究
Marjolein E A Barendse,Robert M Bilder,Anne L Snijders et al.
Marjolein E A Barendse et al.
Background: Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an end...