Corticolimbic Circuitry in Chronic Pain Tracks Pain Intensity Relief Following Exposure In Vivo [0.03%]
慢性疼痛患者在接受治疗后，皮层边缘脑区的连接强度与镇痛效果呈正相关关系研究
Inge Timmers,Vincent G van de Ven,Johan W S Vlaeyen et al.
Inge Timmers et al.
Background: A subset of patients with chronic pain who receive exposure in vivo (EXP) treatment experience clinically relevant relief of pain intensity. Although pain relief is not an explicit therapeutic target, it is im...
Mary E McNamara,Mackenzie Zisser,Christopher G Beevers
Mary E McNamara
Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms [0.03%]
磷二酯酶10抑制剂RG7203治疗以阴性症状为主的 schizophrenia 患者的机制研究
Daniel Umbricht,Markus Abt,Paul Tamburri et al.
Daniel Umbricht et al.
Background: Reduced activation of dopamine D1 receptor signaling may be implicated in reward functioning as a potential driver of negative symptoms in schizophrenia. Phosphodiesterase 10A (PDE10A), an enzyme that is highl...
Neurophysiological Markers Related to Negative Self-referential Processing Differentiate Adolescent Suicide Ideators and Attempters [0.03%]
与青少年自杀想法和行为相关的负性自我加工神经生理标志物
Grace O Allison,Erik M Benau,Steven Asbaghi et al.
Grace O Allison et al.
Background: Adolescent suicide is a major public health concern, and presently, there is a limited understanding of the neurophysiological correlates of suicidal behaviors. Cognitive models of suicide indicate that negati...
Whole-Brain Resting-State Functional Connectivity Patterns Associated With Pediatric Anxiety and Involuntary Attention Capture [0.03%]
与儿童焦虑和非自主注意力捕获相关的全脑静息态功能连接模式
Michael T Perino,Michael J Myers,Muriah D Wheelock et al.
Michael T Perino et al.
Background: Pediatric anxiety disorders are linked to dysfunction in multiple functional brain networks, as well as to alterations in the allocation of spatial attention. We used network-level analyses to characterize res...
A Social Gradient of Cortical Thickness in Adolescence: Relationships With Neighborhood Socioeconomic Disadvantage, Family Socioeconomic Status, and Depressive Symptoms [0.03%]
童年期邻里和家庭社会经济地位对青少年抑郁症状及大脑皮层厚度的影响：一项社会 gradient 研究
Jonas G Miller,Vanessa López,Jessica L Buthmann et al.
Jonas G Miller et al.
Background: Mental and physical health are affected by family and neighborhood socioeconomic status (SES). Accelerated maturation in the context of lower SES is one mechanism that might contribute to underlying health dis...
Prenatal Exposure to Air Pollution and Early-Life Stress Effects on Hippocampal Subregional Volumes and Associations With Visuospatial Reasoning [0.03%]
孕期空气污染和早期生活压力对海马亚区体积的影响及与视觉空间推理的关联
Amy E Margolis,Jacob W Cohen,Bruce Ramphal et al.
Amy E Margolis et al.
Background: Children from economically distressed families and neighborhoods are at risk for stress and pollution exposure and potential neurotoxic sequelae. We examine dimensions of early-life stress affecting hippocampa...
Associations between early-life stress exposure and internalizing symptomatology during the COVID-19 pandemic: Assessing the role of neurobehavioral mediators [0.03%]
新冠肺炎大流行期间早期压力暴露与内在化症状之间的关系：评估神经行为中介因素的作用
Jordan C Foster,Emily M Cohodes,Alexis E Brieant et al.
Jordan C Foster et al.
Background: The ongoing COVID-19 pandemic is a major stressor that has been associated with increased risk for psychiatric illness in the general population. Recent work has highlighted that experiences of early-life stre...
Childhood Maltreatment, Blood Lead Levels, and Crime and Violence: A Prospective Examination [0.03%]
童年虐待、血液铅含量与犯罪和暴力行为的前瞻性研究
Cathy Spatz Widom,Xuechen Li,Anthony Carpi
Cathy Spatz Widom
Background: Research has shown that maltreated children are at increased risk for subsequent crime and violence and are more likely to reside in neighborhoods with a high likelihood of lead exposure. Other literature has ...