Somatostatin Receptor 4 Agonism Normalizes Stress-Related Excessive Amygdala Glutamate Release and Pavlovian Aversion Learning and Memory in Rodents [0.03%]
促肾上腺皮质激素释放激素过度激活时，生长抑素受体4激动作用可调节啮齿类动物基底外侧杏仁核谷氨酸的异常释放及相关厌恶记忆形成
Irina Adamcyzk,Diana Kúkeľová,Stefan Just et al.
Irina Adamcyzk et al.
Background: Excessive processing of aversive life events is a major pathology in stress-related anxiety and depressive disorders. Current pharmacological treatments have rather nonspecific mechanisms of action. Somatostat...
Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children [0.03%]
健康儿童强迫症状相关动态连接模式的神经遗传学研究
Maria Suñol,Silvia Alemany,Mariona Bustamante et al.
Maria Suñol et al.
Background: Obsessive-compulsive symptoms (OCSs) during childhood predispose to obsessive-compulsive disorder and have been associated with changes in brain circuits altered in obsessive-compulsive disorder samples. OCSs ...
Poor Sleep Quality and Daytime Fatigue Are Associated With Subjective but Not Objective Cognitive Functioning in Clinically Relevant Hoarding [0.03%]
睡眠质量差和白天疲劳与临床相关囤积障碍患者的主观认知功能有关，但与客观认知功能无关
Sara K Nutley,Michael Read,Joseph Eichenbaum et al.
Sara K Nutley et al.
Background: Hoarding disorder is a chronic psychiatric condition of increasing public health concern. Recent investigation suggests a positive association between hoarding severity and insomnia symptoms. However, these fi...
Bart Baselmans,Anke R Hammerschlag,Stephany Noordijk et al.
Bart Baselmans et al.
Background: To gain more insight into the biological factors that mediate vulnerability to display externalizing behaviors, we leveraged genome-wide association study summary statistics on 13 externalizing phenotypes. ...
Controllability of Structural Brain Networks and the Waxing and Waning of Negative Affect in Daily Life [0.03%]
结构化脑网络的可控性与日常生活中负面情绪的波动关系研究
Amanda L McGowan,Linden Parkes,Xiaosong He et al.
Amanda L McGowan et al.
Background: The waxing and waning of negative affect in daily life is normative, reflecting an adaptive capacity to respond flexibly to changing circumstances. However, understanding of the brain structure correlates of a...
Perineuronal Nets in the Dorsomedial Striatum Contribute to Behavioral Dysfunction in Mouse Models of Excessive Repetitive Behavior [0.03%]
背侧纹状体星形胶质细胞源性周细胞网在小鼠重复刻板行为障碍模型中的致病作用
Brandy A Briones,Miah N Pitcher,Weston T Fleming et al.
Brandy A Briones et al.
Background: Excessive repetitive behavior is a debilitating symptom of several neuropsychiatric disorders. Parvalbumin-positive inhibitory interneurons in the dorsal striatum have been linked to repetitive behavior, and a...
Katharina Domschke
Katharina Domschke
Common Gray Matter Reductions in Alcohol Use and Obsessive-Compulsive Disorders: A Meta-analysis [0.03%]
酒精使用障碍和强迫症的常见灰质减少：一项荟萃分析研究
Benson W Stevens,James K Morris,Nancy Diazgranados et al.
Benson W Stevens et al.
Background: Though compulsive drinking is a hallmark of alcohol use disorder (AUD), little is known of the neural mechanisms driving this behavior. To further the understanding of the neural underpinnings of this compulsi...
The Role of Analytical Flexibility in Determining Mental Health Biomarkers [0.03%]
分析灵活性在确定心理健康生物标志物中的作用
Janine Bijsterbosch
Janine Bijsterbosch
Aurina Arnatkeviciute,Ben D Fulcher,Mark A Bellgrove et al.
Aurina Arnatkeviciute et al.
Noninvasive neuroimaging is a powerful tool for quantifying diverse aspects of brain structure and function in vivo, and it has been used extensively to map the neural changes associated with various brain disorders. However, most neuroimag...