Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis [0.03%]
遗传途径指出了大麻使用障碍和精神病关联的生物学基础背后的生物学机制
Isabelle Austin-Zimmerman,Qiang Li,Emma C Johnson et al.
Isabelle Austin-Zimmerman et al.
Background: Cannabis use is associated with increased risk of psychotic disorders, but the underlying biological mechanisms remain unclear. We used genetic data to investigate the molecular pathways contributing to the as...
Do Genetic Variants Directly Shape Population-Level Schizophrenia Burden? A Global Genomic Analysis [0.03%]
遗传变异可以直接决定 schizophrenia 的全球疾病负担吗？一项全基因组分析研究
Junxian Tao,Haiyan Chen,Siyu Wei et al.
Junxian Tao et al.
Background: Schizophrenia imposes a substantial global health burden, with marked geographic variation in incidence, prevalence, and disability-adjusted life years (DALYs). Although genome-wide association studies (GWASs)...
Mitul A Mehta,Peter C T Hawkins
Mitul A Mehta
Insular Somatostatin Interneurons Are Targeted by Motor Cortex Efferents and Modulate Affective States [0.03%]
岛状区生长抑素阳性中间神经元接受运动皮层下行轴突投射并调节情感行为
Danielle N Adank,Anne Taylor,Yizhen Quan et al.
Danielle N Adank et al.
Background: Stress-related psychiatric disorders often involve disrupted corticolimbic communication. The mid-insular cortex (mIC) negatively regulates affective behavior through projections to the bed nucleus of the stri...
Characterizing Resting-State Frontoparietal-Amygdala Network Connectivity as a Potential Moderator of the Developmental Link Between Executive Functioning and Internalizing Symptoms: A Group Iterative Multiple Model Estimation-Based Approach [0.03%]
基于群体迭代多模型估计方法探讨执行功能与内部化问题间发展关系的调停变量：静息态前额顶叶-杏仁核网络连接性研究
Felicia A Hardi,Kelley E Gunther,Taylor J Keding et al.
Felicia A Hardi et al.
Background: Risks for internalizing behaviors may be moderated by attentional mechanisms such as inhibitory control and attention shifting. However, research is mixed on whether these dimensions are always favorable. Inhi...
Diverging Trajectories of Depressive Symptoms During Electroconvulsive Therapy: Toward Personalized Treatment [0.03%]
电抽搐治疗过程中抑郁症状的分化趋势：朝向个性化治疗
Kjersti Sellevåg,Christoffer Andreas Bartz-Johannessen,Ketil Joachim Oedegaard et al.
Kjersti Sellevåg et al.
Background: While electroconvulsive therapy (ECT) is an effective treatment for depression, patient responses vary. In addition, there is a lack of guidance in making treatment decisions for patients with an initial nonre...
Altered Theory of Mind Engagement and Neural Alignment in Social Anxiety During Movie Viewing [0.03%]
社交焦虑症患者观看电影时的心智理论参与度和神经协调性改变
Saskia B J Koch,Margot Mangnus,Robin Devillers et al.
Saskia B J Koch et al.
Background: Social anxiety (SA) is marked by a persistent fear of social scrutiny, but its neurocognitive mechanisms remain incompletely understood. We tested whether SA is associated with altered engagement of theory of ...
The Estrogen-Mitochondria Axis in Bipolar Disorder: From Fluctuating Hormones to Failing Bioenergetics [0.03%]
双相情感障碍中的雌激素-线粒体轴：从波动的激素到耗竭的能量代谢
Kassandra A Zachos,Kiana Behravan,Jude Demyati et al.
Kassandra A Zachos et al.
Bipolar disorder (BD) is a psychiatric illness marked by fluctuating mood states and substantial systemic consequences, including dysregulated bioenergetics, immune modulations, and significant metabolic dysfunction. Although BD affects mal...
Convergent and Divergent Cerebellar Alterations in 22q11.2 Copy Number Variants [0.03%]
22q11.2拷贝数变异中小脑改变的一致性和差异性
Hoki Fung,Kathleen P O&#x;Hora,Rune Boen et al.
Hoki Fung et al.
Background: Copy number variants (CNVs) at 22q11.2 confer substantial risk for neurodevelopmental and psychiatric disorders. Both the 22q11.2 deletion (22qDel) and 22q11.2 duplication (22qDup) are associated with increase...
The Gut-Brain Axis as a Mediator of Environmental Endocrine Disruptors in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Mechanistic Synthesis [0.03%]
肠道-大脑轴在环境内分泌干扰物介导注意缺陷多动障碍中的作用：系统评价和机制综合
Hui Wu,Meiqiao Yu,Shuo Huang et al.
Hui Wu et al.
The rising global prevalence of attention-deficit/hyperactivity disorder (ADHD) underscores the importance of environmental factors, particularly environmental endocrine-disrupting chemicals (EEDs), whose mechanistic links to ADHD remain un...