Stress-Induced Dysregulation of the Guidance Cue Receptor DCC Alters Corticolimbic Circuit Architecture [0.03%]
应激通过干扰导向线索受体DCC调节皮层边缘通路结构异常
Ashraf Mahmud,Giovanni Hernandez,Fatme Abboud et al.
Ashraf Mahmud et al.
Background: Elevated expression of the guidance cue receptor gene DCC in the adult prefrontal cortex (PFC) is a hallmark of major depressive disorder. DCC receptors regulate neuronal connectivity and plasticity in adultho...
Efficacy, Effectiveness, and Safety of Transcranial Magnetic Stimulation for Bipolar Depression: A Systematic Review and Meta-Analysis [0.03%]
经颅磁刺激治疗双相抑郁的疗效、有效性和安全性系统评价和 meta 分析
Fabiana Ventura,Pedro Frias,Daniel Rodrigues da Silva et al.
Fabiana Ventura et al.
Background: Repetitive transcranial magnetic stimulation (rTMS) is cleared by the Food and Drug Administration for major depression, and recently received breakthrough status for bipolar depression (BDep). However, eviden...
Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents [0.03%]
早期生活不确定性对青少年海马区和杏仁核 novelty反应的性别差异影响
Elysia Poggi Davis,Bianca T Leonard,Robert J Jirsaraie et al.
Elysia Poggi Davis et al.
Background: Unpredictable childhood experiences are an understudied form of early-life adversity that impact neurodevelopment. The neurobiological processes by which exposure to early-life unpredictability impact developm...
Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs [0.03%]
采用两种遗传设计研究易怒作为潜在原因的风险途径导致抑郁的原因
Amy Shakeshaft,Olakunle Oginni,Joanna Martin et al.
Amy Shakeshaft et al.
Background: Major depressive disorder (MDD) is heterogeneous, with diverse risk pathways leading to illness. Identifying causal routes to depression helps prioritize targets for early intervention and prevention strategie...
Clinical Criteria to Guide Antineuronal Antibody Testing for People With Early and Persistent Psychosis Attending Mental Health Services [0.03%]
指导精神卫生服务机构中早期且持续精神病患者进行抗神经元抗体检测的临床标准
Gemma McKeon,Andrea Baker,Stefan Blum et al.
Gemma McKeon et al.
Background: Early detection of autoimmune psychosis (AP) mediated by antineuronal antibodies (Abs) is critical for achieving optimal clinical outcomes. However, evidence remains limited regarding who should be tested and ...
Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression [0.03%]
拉莫三嗪和治疗性酮体在双相抑郁中的机制交叉的临床见解
Dina N Ali,Iain H Campbell,Jonathan G Leung et al.
Dina N Ali et al.
There are substantial care gaps in optimizing treatment response for bipolar depression given, at best, a modicum of benefit from antidepressant treatment and, in contrast, a substantial cardiometabolic burden associated with regulatory-app...
Altered Interpersonal Neural Synchronization During Social Interaction After Shared Excluded Experiences in Adolescents With Depression [0.03%]
抑郁青少年经历被排斥后的社会交往过程中人际脑同步性改变
Yuwen He,Jieting Chen,Yong Lin et al.
Yuwen He et al.
Background: Major depressive disorder (MDD) is common in adolescents, and adolescents' brains develop intensively but are still immature, making them more vulnerable during social interaction when exposed to public psycho...
Association Between Maternal Genome-Wide Polygenic Scores for Psychiatric and Neurodevelopmental Disorders and Adverse Perinatal Events: A Danish Population-Based Study [0.03%]
基于丹麦全国人群的队列研究：精神疾病和神经发育障碍的全基因组多基因评分与围产期不良事件之间的关联
Fenfen Ge,Yue Wang,Xiaoqin Liu et al.
Fenfen Ge et al.
Background: Phenotypic links between psychiatric disorders and adverse perinatal events are increasingly being reported, but the mechanisms remain unclear. In this study, we aimed to assess how polygenic scores (PGSs) for...